Our Science – Ruscetti Website
Francis W. Ruscetti, Ph.D.
Selected Publications |
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| 1)
Alter HJ, Mikovits JA, Switzer WM, Ruscetti FW, Lo S, Klimas N, Komaroff AL, Montoya JG, Bateman L, Levine S, Peterson D, Levin B, Hanson MR, Genfi A, Bhat M, Zheng H, Wang R, Li B, Hung G, Lee LL, Sameroff S, Heneine W, Coffin J, Hornig M, Lipkin WI. A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus. MBio. 3: e00266-12, 2012. [Journal] |
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| 2)
Kearney MF, Spindler J, Wiegand A, Shao W, Anderson EM, Maldarelli F, Ruscetti FW, Mellors JW, Hughes SH, Le Grice SF, Coffin JM. Multiple sources of contamination in samples from patients reported to have XMRV infection. PLoS ONE. 7: e30889, 2012. [Journal] |
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| 3)
Simmons G, Glynn SA, Komaroff AL, Mikovits JA, Tobler LH, Hackett J, Tang N, Switzer WM, Heneine W, Hewlett IK, Zhao J, Lo SC, Alter HJ, Linnen JM, Gao K, Coffin JM, Kearney MF, Ruscetti FW, Pfost MA, Bethel J, Kleinman S, Holmberg JA, Busch MP. Failure to confirm XMRV/MLVs in the blood of patients with chronic fatigue syndrome: a multi-laboratory study. Science. 334: 814-7, 2011. [Journal] |
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| 4)
Jones KS, Lambert S, Bouttier M, Bénit L, Ruscetti FW, Hermine O, Pique C. Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors. Viruses. 3: 794-810, 2011. [Journal] |
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| 5)
Silverman RH, Das Gupta J, Lombardi VC, Ruscetti FW, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Mikovits JA. Partial retraction. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science. 334: 176, 2011. [Journal] |
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| 6)
Mikovits JA, Lombardi VC, Pfost MA, Hagen KS, Ruscetti FW. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Virulence. 1: 386-90, 2010. [Journal] |
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| 7)
Mikovits JA, Huang Y, Pfost MA, Lombardi VC, Bertolette DC, Hagen KS, Ruscetti FW. Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer. AIDS Rev. 12: 149-52, 2010. [Journal] |
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| 8)
Gordon SN, Weissman AR, Cecchinato V, Fenizia C, Ma ZM, Lee TH, Zaffiri L, Andresen V, Parks RW, Jones KS, Heraud JM, Ferrari MG, Chung HK, Venzon D, Mahieux R, Murphy EL, Jacobson S, Miller CJ, Ruscetti FW, Franchini G. Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques. J. Virol. 84: 3043-58, 2010. [Journal] |
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| 9)
Valeri VW, Hryniewicz A, Andresen V, Jones K, Fenizia C, Bialuk I, Chung HK, Fukumoto R, Washington Parks R, Ferrari MG, Nicot C, Cecchinato V, Ruscetti F, Franchini G. Requirement of the human T-cell leukemia virus p12 and p30 genes for infectivity of human dendritic cells and macaques but not rabbits. Blood. 116: 3809-17, 2010. [Journal] |
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| 10)
Bhatwadekar AD, Guerin EP, Jarajapu YP, Caballero S, Sheridan C, Kent D, Kennedy L, Lansang MC, Ruscetti FW, Pepine CJ, Higgins PJ, Bartelmez SH, Grant MB. Transient inhibition of transforming growth factor-beta1 in human diabetic CD34+ cells enhances vascular reparative functions. Diabetes. 59: 2010-9, 2010. [Journal] |
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| 11)
Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science. 326: 585-9, 2009. [Journal] |
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| 12)
Lambert S, Bouttier M, Vassy R, Seigneuret M, Petrow-Sadowski C, Janvier S, Heveker N, Ruscetti FW, Perret G, Jones KS, Pique C. HTLV-1 uses HSPG and neuropilin 1 for entry by molecular mimicry of VEGF165. Blood. 113: 5176-5185, 2009. [Journal] |
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| 13)
Jones KS, Huang YK, Chevalier SA, Afonso PV, Petrow-Sadowski C, Bertolette DC, Gessain A, Ruscetti FW, Mahieux R. The receptor complex associated with HTLV-3 Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2. J. Virol. 83: 5244-5255, 2009. [Journal] |
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| 14)
Letterio J, Ruscetti F. Derynck R, eds. Role of TGF-beta in myeloid and lympoid homeostatis. In: The TGF-beta Family. NY: Cold Spring Harbor Press; 2008. p. 789-818 [Book Chapter] |
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| 15)
Ruscetti F, Akel S, Birchenall-Roberts M, Cao Z, Roberts A. Jakowlew S, eds. Smad Signaling in Leukemic Growth and Differentiation. In: Transforming Growth Factor-beta in Cancer Therapy. Volume II. Totowa NJ: Humana Press; 2008. p. 247-261 [Book Chapter] |
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| 16)
Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat. Med. 14: 429-36, 2008. [Journal] |
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| 17)
Takenouchi N, Jones KS, Lisinski I, Fugo K, Yao K, Cushman SW, Ruscetti FW, Jacobson S. GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1. J. Virol. 81: 1506-10, 2007. [Journal] |
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| 18)
Akel S, Bertolette D, Petrow-Sadowski C, Ruscetti FW. Levels of Smad7 regulate Smad and mitogen activated kinases (MAPKs) signaling and controls erythroid and megakaryocytic differentiation of erythroleukemia cells. Platelets. 18: 566-78, 2007. [Journal] |
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| 19)
Ortaldo JR, Mason A, Willette-Brown J, Ruscetti FW, Wine J, Back T, Stull T, Bere EW, Feigenbaum L, Winkler-Pickett R, Young HA. Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells. Cell. Immunol. 249: 8-19, 2007. [Journal] |
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| 20)
Jones KS, Fugo K, Petrow-Sadowski C, Huang Y, Bertolette DC, Lisinski I, Cushman SW, Jacobson S, Ruscetti FW. Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. J. Virol. 80: 8291-302, 2006. [Journal] |
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| 21)
Birchenall-Roberts MC, Fu T, Kim SG, Huang YK, Dambach M, Resau JH, Ruscetti FW. K-Ras4B proteins are expressed in the nucleolus: Interaction with nucleolin. Biochem. Biophys. Res. Commun. 348: 540-9, 2006. [Journal] |
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| 22)
Ruscetti FW, Akel S, Bartelmez SH. Autocrine transforming growth factor-beta regulation of hematopoiesis: many outcomes that depend on the context. Oncogene. 24: 5751-63, 2005. [Journal] |
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| 23)
Polianova MT, Ruscetti FW, Pert CB, Ruff MR. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67: 83-92, 2005. [Journal] |
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| 24)
Jones KS, Petrow-Sadowski C, Bertolette DC, Huang Y, Ruscetti FW. Heparan Sulfate Proteoglycans mediate Attachment and Entry of HTLV-1 virions into CD4+ T cells. J. of Virology. 79: 12692-12702, 2005. [Journal] |
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| 25)
Jones KS, Akel S, Petrow-Sadowski C, Huang Y, Bertolette DC, Ruscetti FW. Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta. J Immunol. 174: 4262-70, 2005. [Journal] |
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| 26)
Taub DD, Mikovits JA, Nilsson G, Schaffer EM, Key ML, Petrow-Sadowski C, Ruscetti FW. Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4. Cell. Immunol. 230: 65-80, 2004. [Journal] |
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| 27)
Puri A, Rawat SS, Lin HM, Finnegan CM, Mikovits J, Ruscetti FW, Blumenthal R. An inhibitor of glycosphingolipid metabolism blocks HIV-1 infection of primary T-cells. AIDS. 18: 849-58, 2004. [Journal] |
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| 28)
Ruscetti FW, Bartelmez SH. Cell cycle control and checkpoints in Hematopoietic Stem Cells. Handbook of Stem Cells. 2: 115-126, 2004. [Journal] |
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| 29)
Finnegan CM, Rawat SS, Puri A, Wang JM, Ruscetti FW, Blumenthal R. Ceramide, a target for antiretroviral therapy. Proc. Natl. Acad. Sci. U.S.A. 101: 15452-7, 2004. [Journal] |
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| 30)
Wielgosz MM, Rauch DA, Jones KS, Ruscetti FW, Ratner L. Cholesterol-dependence of HTLV-I infection. AIDS Res Hum Retroviruses. 21: 43-50, 2004. [Journal] |
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| 31)
Birchenall-Roberts MC, Fu T, Bang OS, Dambach M, Resau JH, Sadowski CL, Bertolette DC, Lee HJ, Kim SJ, Ruscetti FW. Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways. J Biol Chem. 279: 25605-13, 2004. [Journal] |
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| 32)
Ruff MR, Polianova M, Yang QE, Leoung GS, Ruscetti FW, Pert CB. Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr HIV Res. 1: 51-67, 2003. [Journal] |
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| 33)
Nath MD, Ruscetti FW, Petrow-Sadowski C, Jones KS. Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation. Blood. 101: 3085-92, 2003. [Journal] |
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| 34)
Cao Z, Flanders KC, Bertolette D, Lyakh LA, Wurthner JU, Parks WT, Letterio JJ, Ruscetti FW, Roberts AB. Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells. Blood. 101: 498-507, 2003. [Journal] |
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| 35)
Polianova MT, Ruscetti FW, Pert CB, Tractenberg RE, Leoung G, Strang S, Ruff MR. Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA). Peptides. 24: 1093-8, 2003. [Journal] |
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| 36)
Akel S, Petrow-Sadowski C, Laughlin MJ, Ruscetti FW. Neutralization of autocrine transforming growth factor-beta in human cord blood CD34(+)CD38(-)Lin(-) cells promotes stem-cell-factor-mediated erythropoietin-independent early erythroid progenitor development and reduces terminal differentiation. Stem Cells. 21: 557-67, 2003. [Journal] |
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| 37)
Muegge K, Young H, Ruscetti F, Mikovits J. Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancer. Ann N Y Acad Sci. 983: 55-70, 2003. [Journal] |
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| 38)
Viard M, Parolini I, Sargiacomo M, Fecchi K, Ramoni C, Ablan S, Ruscetti FW, Wang JM, Blumenthal R. Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells. J Virol. 76: 11584-95, 2002. [Journal] |
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| 39)
Jones KS, Nath M, Petrow-Sadowski C, Baines AC, Dambach M, Huang Y, Ruscetti FW. Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virions. J Virol. 76: 12723-34, 2002. [Journal] |
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| 40)
Welniak LA, Khaled AR, Anver MR, Komschlies KL, Wiltrout RH, Durum S, Ruscetti FR, Blazar BR, Murphy WJ. Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation. J Immunol. 166: 2924-8, 2001. [Journal] |
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| 41)
Lee JK, Back TC, Komschlies KL, Ruscetti FW, Young HA, Wiltrout RH. Hematopoietic switch from lymphoid to granulocytic development in 3LL tumor-bearing mice. In Vivo. 15: 255-63, 2001. [Journal] |
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| 42)
Fang JY, Mikovits JA, Bagni R, Petrow-Sadowski CL, Ruscetti FW. Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation. J Virol. 75: 9753-61, 2001. [Journal] |
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| 43)
Park SH, Birchenall-Roberts MC, Yi Y, Lee BI, Lee DK, Bertolette DC, Fu T, Ruscetti F, Kim SJ. Mechanism of induction of transforming growth factor-beta type II receptor gene expression by v-Src in murine myeloid cells. Cell Growth Differ. 12: 9-18, 2001. [Journal] |
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| 44)
Ruff MR, Melendez-Guerrero LM, Yang QE, Ho WZ, Mikovits JW, Pert CB, Ruscetti FA. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 52: 63-75, 2001. [Journal] |
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| 45)
Mikovits J, Ruscetti F, Zhu W, Bagni R, Dorjsuren D, Shoemaker R. Potential cellular signatures of viral infections in human hematopoietic cells. Dis Markers. 17: 173-8, 2001. [Journal] |
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| 46)
Li BQ, Wetzel MA, Mikovits JA, Henderson EE, Rogers TJ, Gong W, Le Y, Ruscetti FW, Wang JM. The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1. Blood. 97: 2941-7, 2001. [Journal] |
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| 47)
Ruscetti FW, Bartelmez SH. Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance. Int J Hematol. 74: 18-25, 2001. [Journal] |
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This page was last updated on 4/29/2013.
