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Our Science – Valentin Website

Antonio L. Valentin, M.D., Ph.D.

Selected Publications

1)  Kulkarni V, Valentin A, Rosati M, Alicea C, Singh AK, Jalah R, Broderick KE, Sardesai NY, Le Gall S, Mothe B, Brander C, Rolland M, Mullins JI, Pavlakis GN, Felber BK.
Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques.
PLoS ONE. 9: e86254, 2014.
[Journal]
2)  Jalah R, Kulkarni V, Patel V, Rosati M, Alicea C, Bear J, Yu L, Guan Y, Shen X, Tomaras GD, Labranche C, Montefiori DC, Prattipati R, Pinter A, Bess J, Lifson JD, Reed SG, Sardesai NY, Venzon DJ, Valentin A, Pavlakis GN, Felber BK.
DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques.
PLoS ONE. 9: e91550, 2014.
[Journal]
3)  Kulkarni V, Rosati M, Bear J, Pilkington GR, Jalah R, Bergamaschi C, Singh AK, Alicea C, Chowdhury B, Zhang GM, Kim EY, Wolinsky SM, Huang W, Guan Y, LaBranche C, Montefiori DC, Broderick KE, Sardesai NY, Valentin A, Felber BK, Pavlakis GN.
Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques.
Hum Vaccin Immunother. 9: 2081-94, 2013.
[Journal]
4)  Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, von Gegerfelt A, Huang W, Guan Y, Keele BF, Bess JW, Piatak M, Lifson JD, Williams WT, Shen X, Tomaras GD, Amara RR, Robinson HL, Johnson W, Broderick KE, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, Pavlakis GN.
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge.
Proc. Natl. Acad. Sci. U.S.A. 110: 2975-80, 2013.
[Journal]
5)  Kulkarni V, Rosati M, Valentin A, Ganneru B, Singh AK, Yan J, Rolland M, Alicea C, Beach RK, Zhang GM, Le Gall S, Broderick KE, Sardesai NY, Heckerman D, Mothe B, Brander C, Weiner DB, Mullins JI, Pavlakis GN, Felber BK.
HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.
PLoS ONE. 8: e60245, 2013.
[Journal]
6)  Li J, Valentin A, Kulkarni V, Rosati M, Beach RK, Alicea C, Hannaman D, Reed SG, Felber BK, Pavlakis GN.
HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques.
Vaccine. 31: 3747-55, 2013.
[Journal]
7)  Jalah R, Rosati M, Ganneru B, Pilkington GR, Valentin A, Kulkarni V, Bergamaschi C, Chowdhury B, Zhang GM, Beach RK, Alicea C, Broderick KE, Sardesai NY, Pavlakis GN, Felber BK.
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
J. Biol. Chem. 288: 6763-76, 2013.
[Journal]
8)  Kulkarni V, Rosati M, Valentin A, Jalah R, Alicea C, Yu L, Guan Y, Shen X, Tomaras GD, LaBranche C, Montefiori DC, Irene C, Prattipati R, Pinter A, Sullivan SM, Pavlakis GN, Felber BK.
Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.
Hum Vaccin Immunother. 9: 2069-80, 2013.
[Journal]
9)  Kulkarni V, Jalah R, Ganneru B, Bergamaschi C, Alicea C, von Gegerfelt A, Patel V, Zhang G, Chowdhury B, Broderick KE, Sardesai NY, Valentin A, Rosati M, Felber BK, Pavlakis GN.
Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques.
Vaccine. 29: 6742-54, 2011.
[Journal]
10)  von Gegerfelt A, Valentin A, Alicea C, Van Rompay KK, Marthas ML, Montefiori DC, Pavlakis GN, Felber BK.
Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
J. Immunol. 185: 3348-58, 2010.
[Journal]
11)  Valentin A, Morrow M, Poirier RH, Aleman K, Little R, Yarchoan R, Pavlakis GN.
Identification of a potential pharmacological sanctuary for HIV type 1 in a fraction of CD4(+) primary cells.
AIDS Res. Hum. Retroviruses. 26: 79-88, 2010.
[Journal]
12)  Patel V, Valentin A, Kulkarni V, Rosati M, Bergamaschi C, Jalah R, Alicea C, Minang JT, Trivett MT, Ohlen C, Zhao J, Robert-Guroff M, Khan AS, Draghia-Akli R, Felber BK, Pavlakis GN.
Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization.
Vaccine. 28: 4827-36, 2010.
[Journal]
13)  Valentin A, von Gegerfelt A, Rosati M, Miteloudis G, Alicea C, Bergamaschi C, Jalah R, Patel V, Khan AS, Draghia-Akli R, Pavlakis GN, Felber BK.
Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit.
Vaccine. 28: 1962-74, 2010.
[Journal]
14)  Valentin A, Chikhlikar P, Patel V, Rosati M, Maciel M, Chang KH, Silvera P, Felber BK, Pavlakis GN, August JT, Marques ET.
Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes.
Vaccine. 27: 4840-9, 2009.
[Journal]
15)  Rosati M, Bergamaschi C, Valentin A, Kulkarni V, Jalah R, Alicea C, Patel V, von Gegerfelt AS, Montefiori DC, Venzon DJ, Khan AS, Draghia-Akli R, Van Rompay KK, Felber BK, Pavlakis GN.
DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.
Proc. Natl. Acad. Sci. U.S.A. 106: 15831-6, 2009.
[Journal]
16)  Morrow M, Valentin A, Little R, Yarchoan R, Pavlakis GN.
A splenic marginal zone-like peripheral blood CD27+B220- B cell population is preferentially depleted in HIV type 1-infected individuals.
AIDS Res. Hum. Retroviruses. 24: 621-33, 2008.
[Journal]
17)  Rosati M, Valentin A, Jalah R, Patel V, von Gegerfelt A, Bergamaschi C, Alicea C, Weiss D, Treece J, Pal R, Markham PD, Marques ET, August JT, Khan A, Draghia-Akli R, Felber BK, Pavlakis GN.
Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation.
Vaccine. 26: 5223-9, 2008.
[Journal]
18)  Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, Alicea C, Zhang GM, Patel V, Felber BK, Pavlakis GN.
Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.
J. Biol. Chem. 283: 4189-99, 2008.
[Journal]
19)  Jalah R, Rosati M, Kulkarni V, Patel V, Bergamaschi C, Valentin A, Zhang GM, Sidhu MK, Eldridge JH, Weiner DB, Pavlakis GN, Felber BK.
Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids.
DNA Cell Biol. 26: 827-40, 2007.
[Journal]
20)  von Gegerfelt AS, Rosati M, Alicea C, Valentin A, Roth P, Bear J, Franchini G, Albert PS, Bischofberger N, Boyer JD, Weiner DB, Markham P, Israel ZR, Eldridge JH, Pavlakis GN, Felber BK.
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
J. Virol. 81: 1972-9, 2007.
[Journal]
21)  von Gegerfelt AS, Alicea C, Valentin A, Morrow M, van Rompay KK, Ayash-Rashkovsky M, Markham P, Else JG, Marthas ML, Pavlakis GN, Ruprecht RM, Felber BK.
Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques.
AIDS Res. Hum. Retroviruses. 22: 516-28, 2006.
[Journal]
22)  Rosati M, von Gegerfelt A, Roth P, Alicea C, Valentin A, Robert-Guroff M, Venzon D, Montefiori DC, Markham P, Felber BK, Pavlakis GN.
DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.
J. Virol. 79: 8480-92, 2005.
[Journal]
23)  Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina-Gragerova G, Erwin-Cohen R, Chrousos GP, Pavlakis GN.
Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.
J. Virol. 79: 2780-7, 2005.
[Journal]
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This page was last updated on 4/16/2014.