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Shuo Gu, Ph.D.

Selected Publications

1)  Gu S, Jin L, Zhang Y, Huang Y, Zhang F, Valdmanis PN, Kay MA.
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.
Cell. 151: 900-11, 2012.
2)  Gu S, Jin L, Huang Y, Zhang F, Kay MA.
Slicing-independent RISC activation requires the argonaute PAZ domain.
Curr. Biol. 22: 1536-42, 2012.
3)  Valdmanis PN, Gu S, Schüermann N, Sethupathy P, Grimm D, Kay MA.
Expression determinants of mammalian argonaute proteins in mediating gene silencing.
Nucleic Acids Res. 40: 3704-13, 2012.
4)  Gu S, Jin L, Zhang F, Huang Y, Grimm D, Rossi JJ, Kay MA.
Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.
Proc. Natl. Acad. Sci. U.S.A. 108: 9208-13, 2011.
5)  Grimm D, Wang L, Lee JS, Schürmann N, Gu S, Börner K, Storm TA, Kay MA.
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.
J. Clin. Invest. 120: 3106-19, 2010.
6)  Gu S, Kay MA.
How do miRNAs mediate translational repression?.
Silence. 1: 11, 2010.
7)  Gu S, Jin L, Zhang F, Sarnow P, Kay MA.
Biological basis for restriction of microRNA targets to the 3" untranslated region in mammalian mRNAs.
Nat. Struct. Mol. Biol. 16: 144-50, 2009.
8)  Lee NS, Kim DH, Alluin J, Robbins M, Gu S, Li H, Kim J, Salvaterra PM, Rossi JJ.
Functional and intracellular localization properties of U6 promoter-expressed siRNAs, shRNAs, and chimeric VA1 shRNAs in mammalian cells.
RNA. 14: 1823-33, 2008.
9)  Gu S, Ji J, Kim JD, Yee JK, Rossi JJ.
Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs.
Oligonucleotides. 16: 287-95, 2006.
10)  Gu S, Rossi JJ.
Uncoupling of RNAi from active translation in mammalian cells.
RNA. 11: 38-44, 2005.
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This page was last updated on 12/3/2013.