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Our Science – Barr Website

Frederic G. Barr, M.D., Ph.D.

Selected Publications

1)  Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J.
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
Cancer Discov. 4: 216-31, 2014.
[Journal]
2)  Rudzinski ER, Anderson JR, Lyden ER, Bridge JA, Barr FG, Gastier-Foster JM, Bachmeyer K, Skapek SX, Hawkins DS, Teot LA, Parham DM.
Myogenin, AP2ß, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children"s Oncology Group.
Am. J. Surg. Pathol. 38: 654-9, 2014.
[Journal]
3)  Parham DM, Barr FG.
Classification of rhabdomyosarcoma and its molecular basis.
Adv Anat Pathol. 20: 387-97, 2013.
[Journal]
4)  Duan F, Smith LM, Gustafson DM, Zhang C, Dunlevy MJ, Gastier-Foster JM, Barr FG.
Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: A report from the Children's Oncology Group.
Genes Chromosomes Cancer. 51: 662-74, 2012.
[Journal]
5)  Shukla N, Ameur N, Yilmaz I, Nafa K, Lau CY, Marchetti A, Borsu L, Barr FG, Ladanyi M.
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18: 748-57, 2012.
[Journal]
6)  Reichek JL, Duan F, Smith LM, Gustafson DM, O'Connor RS, Zhang C, Dunlevy MJ, Gastier-Foster JM, Barr FG.
Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
Clin. Cancer Res. 17: 1463-73, 2011.
[Journal]
7)  Pressey JG, Anderson JR, Crossman DK, Lynch JC, Barr FG.
Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.
Pediatr Blood Cancer. 57: 930-8, 2011.
[Journal]
8)  Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Nat. Genet. 46: 595-600, 2014.
[Journal]
9)  Sadri N, Barroeta J, Pack SD, Abdullaev Z, Chatterjee B, Puthiyaveettil R, Brooks JS, Barr FG, Zhang PJ.
Malignant round cell tumor of bone with EWSR1-NFATC2 gene fusion.
Virchows Arch. 2014.
[Journal]
10)  Parham DM, Barr FG.
Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds.
Alveolar rhabdomyosarcoma. In: WHO Classification of Tumours of Soft Tissue and Bone.
Lyon: IARC Press; 2013. p. 130-132 [Book Chapter]
11)  Parham DM, Barr FG.
Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds.
Embryonal rhabdomyosarcoma. In: WHO Classification of Tumours of Soft Tissue and Bone.
Lyon: IARC Press; 2013. p. 127-129 [Book Chapter]
12)  Montgomery EA, Barr FG.
Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds.
Pleomorphic rhabdomyosarcoma. In: WHO Classification of Tumours of Soft Tissue and Bone.
Lyon: IARC Press; 2013. p. 132-133 [Book Chapter]
13)  Parham DM, Barr FG.
Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds.
Rhabdomyoma. In: WHO Classification of Tumours of Soft Tissue and Bone.
Lyon: IARC Press; 2013. p. 124-126 [Book Chapter]
14)  Nascimento AF, Barr FG.
Fletcher CD, Bridge JA, Hogendoorn PC, Mertens F, eds.
Spindle cell/sclerosing rhabdomyosarcoma. In: WHO Classification of Tumours of Soft Tissue and Bone.
Lyon: IARC Press; 2013. p. 134-135 [Book Chapter]
15)  Olanich ME, Barr FG.
A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.
Expert Opin. Ther. Targets. [Epub ahead of print], 2013.
[Journal]
16)  Wilson RA, Teng L, Bachmeyer KM, Bissonnette ML, Husain AN, Parham DM, Triche TJ, Wing MR, Gastier-Foster JM, Barr FG, Hawkins DS, Anderson JR, Skapek SX, Volchenboum SL.
A novel algorithm for simplification of complex gene classifiers in cancer.
Cancer Res. 73: 5625-32, 2013.
[Journal]
17)  Rudzinski ER, Teot LA, Anderson JR, Moore J, Bridge JA, Barr FG, Gastier-Foster JM, Skapek SX, Hawkins DS, Parham DM.
Dense Pattern of Embryonal Rhabdomyosarcoma, a Lesion Easily Confused With Alveolar Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children"s Oncology Group.
Am. J. Clin. Pathol. 140: 82-90, 2013.
[Journal]
18)  Hinson AR, Jones R, Crose LE, Belyea BC, Barr FG, Linardic CM.
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front Oncol. 3: 183, 2013.
[Journal]
19)  Skapek SX, Anderson J, Barr FG, Bridge JA, Gastier-Foster JM, Parham DM, Rudzinski ER, Triche T, Hawkins DS.
PAX-FOXO1 Fusion Status Drives Unfavorable Outcome for Children With Rhabdomyosarcoma: A Children's Oncology Group Report.
Pediatr Blood Cancer. [Epub ahead of print], 2013.
[Journal]
20)  Schneider G, Bowser MJ, Shin DM, Barr FG, Ratajczak MZ.
The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.
Int. J. Oncol. 2013.
[Journal]
21)  Barr FG.
New Treatments for Rhabdomyosarcoma: the Importance of Target Practice.
Clin. Cancer Res. 18: 595-597, 2012.
[Journal]
22)  Tarnowski M, Schneider G, Amann G, Clark G, Houghton P, Barr FG, Kenner L, Ratajczak MZ, Kucia M.
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.
Int J Oncol. 41:: 995-1004, 2012.
[Journal]
23)  Haspel RL, Atkinson JB, Barr FG, Kaul KL, Leonard DG, O"Daniel J, Rinder HM, Scott J, Sobel ME, Speights V.
TRIG on TRACK: Educating Pathology Residents in Genomic Medicine.
Personalized Medicine. 9: 187-293, 2012.
[Journal]
24)  Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C.
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.
Cancer Cell. 19: 177-91, 2011.
[Journal]
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This page was last updated on 7/29/2014.