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Our Science – Hinrichs Website

Christian S. Hinrichs, M.D.

Selected Publications

1)  Turcotte S, Gros A, Hogan K, Tran E, Hinrichs CS, Wunderlich JR, Dudley ME, Rosenberg SA.
Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy.
J. Immunol. 191: 2217-25, 2013.
2)  Hinrichs CS, Restifo NP.
Reassessing target antigens for adoptive T-cell therapy.
Nat. Biotechnol. 31: 999-1008, 2013.
3)  Klebanoff CA, Gattinoni L, Palmer DC, Muranski P, Ji Y, Hinrichs CS, Borman ZA, Kerkar SP, Scott CD, Finkelstein SE, Rosenberg SA, Restifo NP.
Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice.
Clin. Cancer Res. 17: 5343-52, 2011.
4)  Kerkar SP, Sanchez-Perez L, Yang S, Borman ZA, Muranski P, Ji Y, Chinnasamy D, Kaiser AD, Hinrichs CS, Klebanoff CA, Scott CD, Gattinoni L, Morgan RA, Rosenberg SA, Restifo NP.
Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.
J. Immunother. 34: 343-52, 2011.
5)  Hinrichs CS, Borman ZA, Gattinoni L, Yu Z, Burns WR, Huang J, Klebanoff CA, Johnson LA, Kerkar SP, Yang S, Muranski P, Palmer DC, Scott CD, Morgan RA, Robbins PF, Rosenberg SA, Restifo NP.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.
Blood. 117: 808-14, 2011.
6)  Burns WR, Zhao Y, Frankel TL, Hinrichs CS, Zheng Z, Xu H, Feldman SA, Ferrone S, Rosenberg SA, Morgan RA.
A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas.
Cancer Res. 70: 3027-33, 2010.
7)  Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP.
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.
Proc. Natl. Acad. Sci. U.S.A. 106: 17469-74, 2009.
8)  Hinrichs CS, Kaiser A, Paulos CM, Cassard L, Sanchez-Perez L, Heemskerk B, Wrzesinski C, Borman ZA, Muranski P, Restifo NP.
Type 17 CD8+ T cells display enhanced antitumor immunity.
Blood. 114: 596-9, 2009.
9)  Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP.
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Nat. Med. 15: 808-13, 2009.
10)  Boni A, Muranski P, Cassard L, Wrzesinski C, Paulos CM, Palmer DC, Gattinoni L, Hinrichs CS, Chan CC, Rosenberg SA, Restifo NP.
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.
Blood. 112: 4746-54, 2008.
11)  Palmer DC, Chan CC, Gattinoni L, Wrzesinski C, Paulos CM, Hinrichs CS, Powell DJ, Klebanoff CA, Finkelstein SE, Fariss RN, Yu Z, Nussenblatt RB, Rosenberg SA, Restifo NP.
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.
Proc. Natl. Acad. Sci. U.S.A. 105: 8061-6, 2008.
12)  Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP.
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.
Blood. 111: 5326-33, 2008.
13)  Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP.
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Blood. 112: 362-73, 2008.
14)  Paulos CM, Wrzesinski C, Kaiser A, Hinrichs CS, Chieppa M, Cassard L, Palmer DC, Boni A, Muranski P, Yu Z, Gattinoni L, Antony PA, Rosenberg SA, Restifo NP.
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.
J. Clin. Invest. 117: 2197-204, 2007.
15)  Paulos CM, Kaiser A, Wrzesinski C, Hinrichs CS, Cassard L, Boni A, Muranski P, Sanchez-Perez L, Palmer DC, Yu Z, Antony PA, Gattinoni L, Rosenberg SA, Restifo NP.
Toll-like receptors in tumor immunotherapy.
Clin. Cancer Res. 13: 5280-9, 2007.
16)  Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, Sato N, Kaiser A, Hinrichs CS, Heinrichs C, Klebanoff CA, Tagaya Y, Restifo NP.
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
J. Immunol. 176: 5255-66, 2006.
17)  Hinrichs CS, Gattinoni L, Restifo NP.
Programming CD8+ T cells for effective immunotherapy.
Curr. Opin. Immunol. 18: 363-70, 2006.
18)  Hinrichs CS, van Way CW.
Esophageal cancer.
Curr Surg. 59: 12-7, 2005.
19)  Hinrichs CS, Palmer DC, Rosenberg SA, Restifo NP.
Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells.
J. Immunother. 28: 517-24, 2005.
20)  Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS, Pise-Masison CA, Radonovich MF, Brady JN, Restifo NP, Berzofsky JA, Leonard WJ.
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
J. Exp. Med. 201: 139-48, 2005.
21)  Finkelstein SE, Heimann DM, Klebanoff CA, Antony PA, Gattinoni L, Hinrichs CS, Hwang LN, Palmer DC, Spiess PJ, Surman DR, Wrzesiniski C, Yu Z, Rosenberg SA, Restifo NP.
Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer.
J. Leukoc. Biol. 76: 333-7, 2004.
22)  Hinrichs CS, Watroba NL, Rezaishiraz H, Giese W, Hurd T, Fassl KA, Edge SB.
Lymphedema secondary to postmastectomy radiation: incidence and risk factors.
Ann. Surg. Oncol. 11: 573-80, 2004.
23)  Hinrichs CS, Gibbs JF, Driscoll D, Kepner JL, Wilkinson NW, Edge SB, Fassl KA, Muir R, Kraybill WG.
The effectiveness of complete decongestive physiotherapy for the treatment of lymphedema following groin dissection for melanoma.
J Surg Oncol. 85: 187-92, 2004.
24)  Hinrichs C, Van Way C.
Applications of electrosurgery: radio frequency ablation of liver tumors.
Curr. Surg. 57: 509-14, 2000.
25)  Van Way C, Hinrichs C.
Electrosurgery 201: basic electrical principles.
Curr. Surg. 57: 261-4, 2000.
Click Here to View Collapsed Bibliography.

This page was last updated on 11/19/2013.