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Our Science – Larson Website

Daniel R. Larson, Ph.D.

Selected Publications

1)  Larson DR, Fritzsch C, Sun L, Meng X, Lawrence DS, Singer RH.
Direct observation of frequency modulated transcription in single cells using light activation.
Elife. 2: e00750, 2013.
2)  Ferguson ML, Larson DR.
Measuring transcription dynamics in living cells using fluctuation analysis.
Methods Mol. Biol. 1042: 47-60, 2013.
3)  Trcek T, Larson DR, Moldón A, Query CC, Singer RH.
Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast.
Cell. 147: 1484-97, 2011.
4)  Larson D, Zenklusen D, Wu B, Chao J, Singer R.
Real-time observation of transcription initiation and elongation on an endogenous yeast gene.
Science. 332: 475-8, 2011.
5)  Zenklusen D, Larson DR, Singer RH.
Single-RNA counting reveals alternative modes of gene expression in yeast.
Nat. Struct. Mol. Biol. 15: 1263-71, 2008.
6)  Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW.
Water-soluble quantum dots for multiphoton fluorescence imaging in vivo.
Science. 300: 1434-6, 2003.
7)  Coulon A, Chow CC, Singer RH, Larson DR.
Eukaryotic transcriptional dynamics: from single molecules to cell populations.
Nat. Rev. Genet. 14: 572-84, 2013.
8)  Palangat M, Larson DR.
Complexity of RNA polymerase II elongation dynamics.
Biochim Biophys Acta. 1819: 667-72, 2012.
9)  Trcek T, Chao JA, Larson DR, Park HY, Zenklusen D, Shenoy SM, Singer RH.
Single-mRNA counting using fluorescent in situ hybridization in budding yeast.
Nat Protoc. 7: 408-19, 2012.
10)  Larson DR.
What do expression dynamics tell us about the mechanism of transcription?.
Curr Opin Genet Dev. 5: 591-9, 2011.
11)  Silverman SJ, Petti AA, Slavov N, Parsons L, Briehof R, Thiberge SY, Zenklusen D, Gandhi SJ, Larson DR, Singer RH, Botstein D.
Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate.
Proc. Natl. Acad. Sci. U.S.A. 107: 6946-51, 2010.
12)  Larson DR, Johnson MC, Webb WW, Vogt VM.
Visualization of retrovirus budding with correlated light and electron microscopy.
Proc. Natl. Acad. Sci. U.S.A. 102: 15453-8, 2005.
13)  Larson DR.
The economy of photons.
Nat. Methods. 7: 357-9, 2010.
14)  Larson DR, Singer RH, Zenklusen D.
A single molecule view of gene expression.
Trends Cell Biol. 19: 630-7, 2009.
15)  Magalhaes MA, Larson DR, Mader CC, Bravo-Cordero JJ, Gil-Henn H, Oser M, Chen X, Koleske AJ, Condeelis J.
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.
J. Cell Biol. 195: 903-20, 2011.
16)  Lionnet T, Wu B, Grünwald D, Singer RH, Larson DR.
Nuclear physics: quantitative single-cell approaches to nuclear organization and gene expression.
Cold Spring Harb Symp Quant Biol. 75: 113-26, 2011.
17)  Lee HM, Larson DR, Lawrence DS.
Illuminating the chemistry of life: design, synthesis, and applications of.
ACS Chem. Biol. 4: 409-27, 2009.
18)  Darzacq X, Yao J, Larson DR, Causse SZ, Bosanac L, de Turris V, Ruda VM, Lionnet T, Zenklusen D, Guglielmi B, Tjian R, Singer RH.
Imaging transcription in living cells.
Annu Rev Biophys. 38: 173-96, 2009.
19)  Larson D, Ow H, Vishwasrao H, Heikal A, Wiesner U, Web W.
Silica Nanoparticle Architecture Determines Radiative Properties of Encapsulated Fluorophores.
Chem. Mater. 20: 2677-2684, 2008.
Full Text Article. [Journal]
20)  Yao J, Larson DR, Vishwasrao HD, Zipfel WR, Webb WW.
Blinking and nonradiant dark fraction of water-soluble quantum dots in aqueous solution.
Proc. Natl. Acad. Sci. U.S.A. 102: 14284-9, 2005.
21)  Ow H, Larson DR, Srivastava M, Baird BA, Webb WW, Wiesner U.
Bright and stable core-shell fluorescent silica nanoparticles.
Nano Lett. 5: 113-7, 2005.
22)  Yao J, Larson DR, Zipfel WR, Webb WW.
Dark fraction and blinking of water-soluble quantum dots in solution (Proceedings of SPIE: Nanobiophotonics and Biomedical Applications II).
Cartwright AN, Osinski M, eds.
Volume 5705. p. 148-151. [Meeting Proceeding]
23)  Larson DR, Gosse JA, Holowka DA, Baird BA, Webb WW.
Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells.
J. Cell Biol. 171: 527-36, 2005.
24)  Chitu V, Pixley FJ, Macaluso F, Larson DR, Condeelis J, Yeung YG, Stanley ER.
The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.
Mol. Biol. Cell. 16: 2947-59, 2005.
25)  Larson DR, Ma YM, Vogt VM, Webb WW.
Direct measurement of Gag-Gag interaction during retrovirus assembly with FRET and fluorescence correlation spectroscopy.
J. Cell Biol. 162: 1233-44, 2003.
26)  Thompson RE, Larson DR, Webb WW.
Precise nanometer localization analysis for individual fluorescent probes.
Biophys. J. 82: 2775-83, 2002.
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This page was last updated on 11/25/2013.