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Our Science – Westlake Website

Christopher J. Westlake, Ph.D.

Selected Publications

1)  Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG.
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.
Proc. Natl. Acad. Sci. U.S.A. 104: 1236-41, 2007.
[Journal]
2)  Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
Cell. 129: 1201-13, 2007.
[Journal]
3)  Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
Proc. Natl. Acad. Sci. U.S.A. 108: 2759-64, 2011.
[Journal]
4)  Asante D, Maccarthy-Morrogh L, Townley AK, Weiss MA, Katayama K, Palmer KJ, Suzuki H, Westlake CJ, Stephens DJ.
A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.
J. Cell. Sci. 126: 5189-97, 2013.
[Journal]
5)  Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS.
Casein kinase 1d functions at the centrosome and Golgi to promote ciliogenesis.
Mol. Biol. Cell. 25: 1629-40, 2014.
[Journal]
6)  Jia J, Bosley AD, Thompson A, Hoskins JW, Cheuk A, Collins I, Parikh H, Xiao Z, Ylaya K, Dzyadyk M, Cozen W, Hernandez BY, Lynch CF, Loncarek J, Altekruse SF, Zhang L, Westlake CJ, Factor VM, Thorgeirsson S, Bamlet WR, Hewitt SM, Petersen GM, Andresson T, Amundadottir LT.
CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells.
Cancer Res. 74: 2785-95, 2014.
[Journal]
7)  Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM.
Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.
Chem. Biol. 18: 1300-11, 2011.
[Journal]
8)  O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Jackson P, Khanna H, Katsanis N, Hildebrandt F.
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
J. Clin. Invest. 120: 791-802, 2010.
[Journal]
9)  Bandler PE, Westlake CJ, Grant CE, Cole SP, Deeley RG.
Identification of regions required for apical membrane localization of human multidrug resistance protein 2.
Mol. Pharmacol. 74: 9-19, 2008.
[Journal]
10)  Deeley RG, Westlake C, Cole SP.
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.
Physiol. Rev. 86: 849-99, 2006.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 6/17/2014.