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Our Science – Westlake Website

Christopher J. Westlake, Ph.D.

Selected Publications

1)  Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM.
Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.
Chem. Biol. 18: 1300-11, 2011.
2)  Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
Proc. Natl. Acad. Sci. U.S.A. 108: 2759-64, 2011.
3)  O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson PK, Jackson P, Khanna H, Katsanis N, Hildebrandt F.
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.
J. Clin. Invest. 120: 791-802, 2010.
4)  Bandler PE, Westlake CJ, Grant CE, Cole SP, Deeley RG.
Identification of regions required for apical membrane localization of human multidrug resistance protein 2.
Mol. Pharmacol. 74: 9-19, 2008.
5)  Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
Cell. 129: 1201-13, 2007.
6)  Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG.
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.
Proc. Natl. Acad. Sci. U.S.A. 104: 1236-41, 2007.
7)  Deeley RG, Westlake C, Cole SP.
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.
Physiol. Rev. 86: 849-99, 2006.
8)  Payen L, Gao M, Westlake C, Theis A, Cole SP, Deeley RG.
Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1).
Mol. Pharmacol. 67: 1944-53, 2005.
9)  Westlake CJ, Cole SP, Deeley RG.
Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking.
Mol. Biol. Cell. 16: 2483-92, 2005.
10)  Westlake CJ, Payen L, Gao M, Cole SP, Deeley RG.
Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region.
J. Biol. Chem. 279: 53571-83, 2004.
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This page was last updated on 5/3/2013.