Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Lal Website

Ashish Lal, Ph.D.

Selected Publications

1)  Subramanian M, Francis P, Bilke S, Li XL, Hara T, Lu X, Jones M, Walker R, Zhu Y, Pineda M, Lee C, Varanasi L, Yang Y, Martinez L, Luo J, Ambs S, Sharma S, Wakefield L, Meltzer P, Lal A.
A mutant p53/let-7i axis regulated gene network drives cell migration, invasion and metastasis.
Oncogene. 2014.
In Press. [Journal]
2)  Subramanian M, Li X, Hara T, Lal A.
A biochemical approach to identify direct microRNA targets. In: Methods in Molecular Biology, Regulatory noncoding RNAs (Humana Press-Springer Sciences).
2013. In Press. [Book Chapter]
3)  Li XL, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, Walker RL, Pineda M, Zhu Y, Yang Y, Luo J, Wakefield LM, Brabletz T, Park BH, Sharma S, Chowdhury D, Meltzer PS, Lal A.
A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the miR-183-96-182 cluster.
Mol. Cell. Biol. 2013.
4)  Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L.
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
J. Clin. Invest. 123: 4479-88, 2013.
5)  Subramanian M, Jones MF, Lal A.
Long Non-Coding RNAs Embedded in the Rb and p53 Pathways.
Cancers (Basel). 5: 1655-75, 2013.
6)  Lu X, Parvathaneni S, Hara T, Lal A, Sharma S.
Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D.
Mol. Cancer. 12: 29, 2013.
7)  Tripathi V, Shen Z, Chakraborty A, Giri S, Freier SM, Wu X, Zhang Y, Gorospe M, Prasanth SG, Lal A, Prasanth KV.
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB.
PLoS Genet. 9: e1003368, 2013.
8)  Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A.
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.
J. Biol. Chem. 287: 3976-86, 2012.
9)  Abdelmohsen K, Srikantan S, Tominaga K, Kang M, Yaniv Y, Martindale JL, Yang X, Park S, Becker KG, Subramanian M, Maudsley S, Lal A, Gorospe M.
Growth inhibition by miR-519 via multiple p21-inducing pathways.
Mol Cell Biol. 32:: 2530-48, 2012.
10)  Jones M, Lal A.
MicroRNAs, wild-type and mutant p53: more questions than answers.
RNA Biol. 9: 781-91, 2012.
11)  Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J.
Capture of MicroRNA-Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling.
PLoS Genet. 7: e1002363, 2011.
12)  Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B.
Conserved Regulation of p53 Network Dosage by MicroRNA-125b Occurs through Evolving miRNA-Target Gene Pairs.
PLoS Genet. 7: e1002242, 2011.
13)  Thomas M, Lieberman J, Lal A.
Desperately seeking microRNA targets.
Nat. Struct. Mol. Biol. 17: 1169-74, 2010.
14)  Jensen DK, Lal A.
Micromanaging senescence.
Aging (Albany NY). 2: 322-3, 2010.
15)  O'Day E, Lal A.
MicroRNAs and their target gene networks in breast cancer.
Breast Cancer Res. 12: 201, 2010.
16)  Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A.
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.
EMBO J. 29: 559-73, 2010.
17)  Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D.
Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.
Cell Host Microbe. 5: 84-94, 2009.
18)  Mazan-Mamczarz K, Kuwano Y, Zhan M, White EJ, Martindale JL, Lal A, Gorospe M.
Identification of a signature motif in target mRNAs of RNA-binding protein AUF1.
Nucleic Acids Res. 37: 204-14, 2009.
19)  Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J.
miR-200 enhances mouse breast cancer cell colonization to form distant metastases.
PLoS ONE. 4: e7181, 2009.
20)  Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J.
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to.
Mol. Cell. 35: 610-25, 2009.
21)  Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D.
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.
Nat. Struct. Mol. Biol. 16: 492-8, 2009.
22)  Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim HH, Kuwano Y, Galban S, Becker KG, Kamara D, de Cabo R, Gorospe M.
Ubiquitin-mediated proteolysis of HuR by heat shock.
EMBO J. 28: 1271-82, 2009.
23)  Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M.
Nuclear HuR accumulation through phosphorylation by Cdk1.
Genes Dev. 22: 1804-15, 2008.
24)  Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M.
p16(INK4a) translation suppressed by miR-24.
PLoS ONE. 3: e1864, 2008.
25)  van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, Cai H, Bonini NM, Gorospe M, Cookson MR.
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
Proc. Natl. Acad. Sci. U.S.A. 105: 10244-9, 2008.
26)  Galbán S, Kuwano Y, Pullmann R, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M.
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.
Mol. Cell. Biol. 28: 93-107, 2008.
27)  Pullmann R, Kim HH, Abdelmohsen K, Lal A, Martindale JL, Yang X, Gorospe M.
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs.
Mol. Cell. Biol. 27: 6265-78, 2007.
28)  Abdelmohsen K, Pullmann R, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M.
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
Mol. Cell. 25: 543-57, 2007.
29)  Abdelmohsen K, Lal A, Kim HH, Gorospe M.
Posttranscriptional orchestration of an anti-apoptotic program by HuR.
Cell Cycle. 6: 1288-92, 2007.
30)  Pullmann R, Abdelmohsen K, Lal A, Martindale JL, Ladner RD, Gorospe M.
Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1.
J. Biol. Chem. 281: 23456-63, 2006.
31)  Lal A, Gorospe M.
Egad, more forms of gene regulation: the gadd45a story.
Cell Cycle. 5: 1422-5, 2006.
32)  Mohit P, Makhijani K, Madhavi MB, Bharathi V, Lal A, Sirdesai G, Reddy VR, Ramesh P, Kannan R, Dhawan J, Shashidhara LS.
Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila.
Dev. Biol. 291: 356-67, 2006.
33)  Lal A, Abdelmohsen K, Pullmann R, Kawai T, Galban S, Yang X, Brewer G, Gorospe M.
Posttranscriptional derepression of GADD45alpha by genotoxic stress.
Mol. Cell. 22: 117-28, 2006.
34)  Kawai T, Lal A, Yang X, Galban S, Mazan-Mamczarz K, Gorospe M.
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.
Mol. Cell. Biol. 26: 3295-307, 2006.
35)  Mazan-Mamczarz K, Lal A, Martindale JL, Kawai T, Gorospe M.
Translational repression by RNA-binding protein TIAR.
Mol. Cell. Biol. 26: 2716-27, 2006.
36)  Lal A, Kawai T, Yang X, Mazan-Mamczarz K, Gorospe M.
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha.
EMBO J. 24: 1852-62, 2005.
37)  Lal A, Haynes SR, Gorospe M.
Clean Western blot signals from immunoprecipitated samples.
Mol. Cell. Probes. 19: 385-8, 2005.
38)  López de Silanes I, Lal A, Gorospe M.
HuR: post-transcriptional paths to malignancy.
RNA Biol. 2: 11-3, 2005.
39)  Lal A, Plaxton WC, Kayastha AM.
Purification and characterization of an allosteric fructose-1,6-bisphosphate aldolase from germinating mung beans (Vigna radiata).
Phytochemistry. 66: 968-74, 2005.
40)  Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL, Gorospe M.
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.
EMBO J. 23: 3092-102, 2004.
41)  López de Silanes I, Zhan M, Lal A, Yang X, Gorospe M.
Identification of a target RNA motif for RNA-binding protein HuR.
Proc. Natl. Acad. Sci. U.S.A. 101: 2987-92, 2004.
42)  Yang X, Wang W, Fan J, Lal A, Yang D, Cheng H, Gorospe M.
Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.
J. Biol. Chem. 279: 49298-306, 2004.
43)  Prasanth KV, Rajendra TK, Lal AK, Lakhotia SC.
Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila.
J. Cell. Sci. 113 Pt 19: 3485-97, 2000.
44)  Lal AK, Kayastha AM, Malhotra OP.
Interactions of aldolase and glyceraldehyde-3-phosphate dehydrogenase: molecular mass studies.
Biochem. Mol. Biol. Int. 42: 507-15, 1997.
Click Here to View Collapsed Bibliography.

This page was last updated on 1/2/2014.