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Our Science – Stommel Website

Jayne M. Stommel, Ph.D.

Selected Publications

1)  Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Science. 318: 287-90, 2007.
2)  Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Genes Dev. 21: 2683-710, 2007.
3)  Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA.
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Nature. 455: 1129-33, 2008.
4)  Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, Paik JH, Segatto O, Brennan C, Elferink LA, Wang YA, Chin L, DePinho RA.
Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Proc. Natl. Acad. Sci. U.S.A. 107: 6912-7, 2010.
5)  Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.
Pancreatic cancers require autophagy for tumor growth.
Genes Dev. 25: 717-29, 2011.
6)  Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W.
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
Cancer Cell. 18: 147-59, 2010.
7)  Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC.
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.
PLoS ONE. 5: e10767, 2010.
8)  Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA.
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Cold Spring Harb. Symp. Quant. Biol. 73: 427-37, 2008.
9)  Wade M, Wong ET, Tang M, Stommel JM, Wahl GM.
Hdmx modulates the outcome of p53 activation in human tumor cells.
J. Biol. Chem. 281: 33036-44, 2006.
10)  Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA.
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Cancer Cell. 9: 379-90, 2006.
11)  Stommel JM, Wahl GM.
A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation.
Cell Cycle. 4: 411-7, 2005.
12)  Stommel JM, Wahl GM.
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation.
EMBO J. 23: 1547-56, 2004.
13)  Jimenez GS, Nister M, Stommel JM, Beeche M, Barcarse EA, Zhang XQ, O'Gorman S, Wahl GM.
A transactivation-deficient mouse model provides insights into Trp53 regulation and function.
Nat. Genet. 26: 37-43, 2000.
14)  Stommel JM, Marchenko ND, Jimenez GS, Moll UM, Hope TJ, Wahl GM.
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.
EMBO J. 18: 1660-72, 1999.
15)  Jimenez GS, Khan SH, Stommel JM, Wahl GM.
p53 regulation by post-translational modification and nuclear retention in response to diverse stresses.
Oncogene. 18: 7656-65, 1999.
16)  Miltenberger RJ, Farnham PJ, Smith DE, Stommel JM, Cornwell MM.
v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1.
Cell Growth Differ. 6: 549-56, 1995.
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This page was last updated on 6/17/2014.