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Our Science – Callen Moreu Website

Elsa Callen Moreu, Ph.D.

Selected Publications

1)  Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Cell. 153: 1266-80, 2013.
[Journal]
2)  Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.
Functional Intersection of ATM and DNA-PKcs in Coding End Joining During V(D)J Recombination.
Mol. Cell. Biol. 2013.
[Journal]
3)  Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.
Identification of early replicating fragile sites that contribute to genome instability.
Cell. 152: 620-32, 2013.
[Journal]
4)  Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC.
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science. 339: 711-5, 2013.
[Journal]
5)  Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A.
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Mol. Cell. 46: 125-35, 2012.
[Journal]
6)  Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Immunity. 37: 971-85, 2012.
[Journal]
7)  Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC.
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
EMBO J. 31: 4045-56, 2012.
[Journal]
8)  Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP.
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Proc. Natl. Acad. Sci. U.S.A. 108: 2022-7, 2011.
[Journal]
9)  Castella M, Pujol R, Callén E, Ramírez MJ, Casado JA, Talavera M, Ferro T, Muñoz A, Sevilla J, Madero L, Cela E, Beléndez C, de Heredia CD, Olivé T, de Toledo JS, Badell I, Estella J, Dasí Á, Rodríguez-Villa A, Gómez P, Tapia M, Molinés A, Figuera Á, Bueren JA, Surrallés J.
Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact.
J. Med. Genet. 48: 242-50, 2011.
[Journal]
10)  Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, Zhang CC, Chen DJ, Chen BP.
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
J. Cell Biol. 193: 295-305, 2011.
[Journal]
11)  Castella M, Pujol R, Callén E, Trujillo JP, Casado JA, Gille H, Lach FP, Auerbach AD, Schindler D, Benítez J, Porto B, Ferro T, Muñoz A, Sevilla J, Madero L, Cela E, Beléndez C, de Heredia CD, Olivé T, de Toledo JS, Badell I, Torrent M, Estella J, Dasí A, Rodríguez-Villa A, Gómez P, Barbot J, Tapia M, Molinés A, Figuera A, Bueren JA, Surrallés J.
Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations.
Blood. 117: 3759-69, 2011.
[Journal]
12)  Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
Mol. Cell. 42: 319-29, 2011.
[Journal]
13)  Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Cell. 141: 243-54, 2010.
[Journal]
14)  Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A.
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.
Cell Cycle. 8: 2408-12, 2009.
[Journal]
15)  Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Mol. Cell. 34: 285-97, 2009.
[Journal]
16)  Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.
Histone H2AX is integral to hypoxia-driven neovascularization.
Nat. Med. 15: 553-8, 2009.
[Journal]
17)  Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Nature. 456: 529-33, 2008.
[Journal]
18)  Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Genes Dev. 22: 2048-61, 2008.
[Journal]
19)  Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R.
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
J. Exp. Med. 205: 1949-57, 2008.
[Journal]
20)  Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.
Cell. 135: 1028-38, 2008.
[Journal]
21)  Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Cell. 130: 63-75, 2007.
[Journal]
22)  Callén E, Nussenzweig MC, Nussenzweig A.
Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly.
Oncogene. 26: 7759-64, 2007.
[Journal]
23)  Kalb R, Neveling K, Hoehn H, Schneider H, Linka Y, Batish SD, Hunt C, Berwick M, Callen E, Surralles J, Casado JA, Bueren J, Dasi A, Soulier J, Gluckman E, Zwaan CM, van Spaendonk R, Pals G, de Winter JP, Joenje H, Grompe M, Auerbach AD, Hanenberg H, Schindler D.
Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.
Am. J. Hum. Genet. 80: 895-910, 2007.
[Journal]
24)  Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC.
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Nature. 440: 105-9, 2006.
[Journal]
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This page was last updated on 8/16/2013.