Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Lin Website

Pengnian Charles Lin, Ph.D.

Selected Publications

1)  Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, Yen Y, Wang Y, Marcusson EG, Chu P, Wu J, Wu X, Li AX, Li Z, Gao H, Ren X, Boldin MP, Lin PC, Wang SE.
Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis.
Cancer Cell. 25: 501-15, 2014.
2)  Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H.
Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.
Oncoimmunology. 2: e26677, 2013.
3)  Qu P, Boelte KC, Lin PC.
Negative regulation of myeloid-derived suppressor cells in cancer.
Immunol. Invest. 41: 562-80, 2012.
4)  Sun J, Gao Y, Isaacs RJ, Boelte KC, Lin PC, Boczko EM, Li D.
Simultaneous on-chip DC dielectrophoretic cell separation and quantitative separation performance characterization.
Anal. Chem. 84: 2017-24, 2012.
5)  Gao Y, Majumdar D, Jovanovic B, Shaifer C, Lin PC, Zijlstra A, Webb DJ, Li D.
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology.
Biomed Microdevices. 13: 539-48, 2011.
6)  Min Y, Ghose S, Boelte K, Li J, Yang L, Lin PC.
C/EBP-delta regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1alpha.
Oncogene. 30: 4901-9, 2011.
7)  Boutté AM, McDonald WH, Shyr Y, Yang L, Lin PC.
Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics.
PLoS ONE. 6: e22446, 2011.
8)  Boutté AM, Friedman DB, Bogyo M, Min Y, Yang L, Lin PC.
Identification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasis.
FASEB J. 25: 2626-37, 2011.
9)  Boelte KC, Gordy LE, Joyce S, Thompson MA, Yang L, Lin PC.
Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1.
PLoS ONE. 6: e18534, 2011.
10)  Shaifer CA, Huang J, Lin PC.
Glioblastoma cells incorporate into tumor vasculature and contribute to vascular radioresistance.
Int J Cancer. 127: 2063-75, 2010.
11)  DeBusk LM, Boelte K, Min Y, Lin PC.
Heterozygous deficiency of delta-catenin impairs pathological angiogenesis.
J. Exp. Med. 207: 77-84, 2010.
12)  Kobayashi H, Huang J, Ye F, Shyr Y, Blackwell TS, Lin PC.
Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model.
PLoS ONE. 5: e9458, 2010.
13)  Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL.
Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators.
Oncogene. 29: 3335-48, 2010.
14)  Jiang M, Min Y, Debusk L, Fernandez S, Strand DW, Hayward SW, Lin PC.
Spontaneous immortalization of human dermal microvascular endothelial cells.
World J Stem Cells. 2: 114-20, 2010.
15)  Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X.
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Proc. Natl. Acad. Sci. U.S.A. 107: 11307-12, 2010.
16)  Min Y, Ren X, Vaught DB, Chen J, Donnelly E, Lynch CC, Lin PC.
Tie2 signaling regulates osteoclastogenesis and osteolytic bone invasion of breast cancer.
Cancer Res. 70: 2819-28, 2010.
17)  Kobayashi H, Lin PC.
Angiogenesis links chronic inflammation with cancer.
Methods Mol. Biol. 511: 185-91, 2009.
18)  Kobayashi H, Yazlovitskaya EM, Lin PC.
Interleukin-32 positively regulates radiation-induced vascular inflammation.
Int. J. Radiat. Oncol. Biol. Phys. 74: 1573-9, 2009.
19)  Kobayashi H, Lin PC.
Molecular characterization of IL-32 in human endothelial cells.
Cytokine. 46: 351-8, 2009.
20)  Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL.
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Cancer Cell. 13: 23-35, 2008.
21)  DeBusk LM, Massion PP, Lin PC.
IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis.
Cancer Res. 68: 10223-8, 2008.
22)  Yankeelov TE, Luci JJ, DeBusk LM, Lin PC, Gore JC.
Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: theory, simulations, and experimental results.
Magn Reson Med. 59: 326-35, 2008.
23)  Kobayashi H, Boelte KC, Lin PC.
Endothelial cell adhesion molecules and cancer progression.
Curr. Med. Chem. 14: 377-86, 2007.
24)  Kobayashi H, Lin PC.
A combinatin approach for cancer therapy: antiangiogenic with ionizing radiation. Histology and Histopathology.
Cellcular and Molecular Biology. 108: 1260, 2006.
25)  Kamiyama M, Pozzi A, Yang L, DeBusk LM, Breyer RM, Lin PC.
EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival.
Oncogene. 25: 7019-28, 2006.
26)  Kobayashi H, DeBusk LM, Babichev YO, Dumont DJ, Lin PC.
Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.
Blood. 108: 1260-6, 2006.
27)  Kobayashi H, Lin PC.
Nanotechnology for antiangiogenic cancer therapy.
Nanomedicine (Lond). 1: 17-22, 2006.
28)  Yankeelov TE, DeBusk LM, Billheimer DD, Luci JJ, Lin PC, Price RR, Gore JC.
Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T.
J Magn Reson Imaging. 24: 1140-7, 2006.
29)  Yu J, Ren X, Cao S, Zhang W, Hao X.
Th1 polarization and apoptosis-inducing activity of CD4+ T -cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokine-induced killers in vivo.
Cancer Biother. Radiopharm. 21: 276-84, 2006.
30)  Chen Y, Donnelly E, Kobayashi H, Debusk LM, Lin PC.
Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction.
Arthritis Rheum. 52: 1585-94, 2005.
31)  Shin I, Edl J, Biswas S, Lin PC, Mernaugh R, Arteaga CL.
Proapoptotic activity of cell-permeable anti-Akt single-chain antibodies.
Cancer Res. 65: 2815-24, 2005.
32)  Yankeelov TE, Luci JJ, Lepage M, Li R, Debusk L, Lin PC, Price RR, Gore JC.
Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model.
Magn Reson Imaging. 23: 519-29, 2005.
33)  DeBusk LM, Hallahan DE, Lin PC.
Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway.
Exp. Cell Res. 298: 167-77, 2004.
34)  Nishishita T, Lin PC.
Angiopoietin 1, PDGF-B, and TGF-beta gene regulation in endothelial cell and smooth muscle cell interaction.
J. Cell. Biochem. 91: 584-93, 2004.
35)  Chen JX, Chen Y, DeBusk L, Lin W, Lin PC.
Dual functional roles of Tie-2/angiopoietin in TNF-alpha-mediated angiogenesis.
Am. J. Physiol. Heart Circ. Physiol. 287: H187-95, 2004.
36)  Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC.
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.
Cancer Cell. 6: 409-21, 2004.
37)  Peters KG, Kontos CD, Lin PC, Wong AL, Rao P, Huang L, Dewhirst MW, Sankar S.
Functional significance of Tie2 signaling in the adult vasculature.
Recent Prog. Horm. Res. 59: 51-71, 2004.
38)  Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, Powers AC.
Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets.
Diabetes. 53: 1318-25, 2004.
39)  Roberts RL, Lin PC.
Structural and functional optical imaging of angiogenesis in animal models.
Meth. Enzymol. 386: 105-22, 2004.
40)  Lin PC.
Optical imaging and tumor angiogenesis.
J. Cell. Biochem. 90: 484-91, 2003.
41)  DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC.
Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis.
Arthritis Rheum. 48: 2461-71, 2003.
42)  Brantley DM, Cheng N, Thompson EJ, Lin Q, Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D, Lin C, Chen J.
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.
Oncogene. 21: 7011-26, 2002.
43)  Geng L, Donnelly E, McMahon G, Lin PC, Sierra-Rivera E, Oshinka H, Hallahan DE.
Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy.
Cancer Res. 61: 2413-9, 2001.
44)  Tomanek RJ, Zheng W, Peters KG, Lin P, Holifield JS, Suvarna PR.
Multiple growth factors regulate coronary embryonic vasculogenesis.
Dev. Dyn. 221: 265-73, 2001.
45)  Li CY, Shan S, Huang Q, Braun RD, Lanzen J, Hu K, Lin P, Dewhirst MW.
Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.
J. Natl. Cancer Inst. 92: 143-7, 2000.
46)  Huang L, Sankar S, Lin C, Kontos CD, Schroff AD, Cha EH, Feng SM, Li SF, Yu Z, Van Etten RL, Blanar MA, Peters KG.
HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.
J. Biol. Chem. 274: 38183-8, 1999.
47)  Hughes GC, Annex BH, Yin B, Pippen AM, Lin P, Kypson AP, Peters KG, Lowe JE, Landolfo KP.
Transmyocardial laser revascularization limits in vivo adenoviral-mediated gene transfer in porcine myocardium.
Cardiovasc. Res. 44: 81-90, 1999.
48)  Lin P, Buxton JA, Acheson A, Radziejewski C, Maisonpierre PC, Yancopoulos GD, Channon KM, Hale LP, Dewhirst MW, George SE, Peters KG.
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Proc. Natl. Acad. Sci. U.S.A. 95: 8829-34, 1998.
49)  Annex BH, Torgan CE, Lin P, Taylor DA, Thompson MA, Peters KG, Kraus WE.
Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle.
Am. J. Physiol. 274: H860-7, 1998.
50)  Lin P, Sankar S, Shan S, Dewhirst MW, Polverini PJ, Quinn TQ, Peters KG.
Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.
Cell Growth Differ. 9: 49-58, 1998.
51)  Lin P, Polverini P, Dewhirst M, Shan S, Rao PS, Peters K.
Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.
J. Clin. Invest. 100: 2072-8, 1997.
Click Here to View Collapsed Bibliography.

This page was last updated on 5/8/2014.