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Our Science – Oberdoerffer Website

Philipp Oberdoerffer, Ph.D.

Selected Publications

1)  Khurana S, Kruhlak M, Kim J, Tran A, Liu J, Nyswaner K, Shi L, Jailwala P, Sung M, Hakim O, Oberdoerffer P.
A macro-histone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.
Cell Rep. 2014.
In Press. [Journal]
2)  Liu J, Kim J, Oberdoerffer P.
Metabolic modulation of chromatin: implications for DNA repair and genomic integrity.
Front Genet. 4: 182, 2013.
3)  Singh SK, Williams CA, Klarmann K, Burkett SS, Keller JR, Oberdoerffer P.
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.
J. Exp. Med. 210: 987-1001, 2013.
4)  Shi L, Oberdoerffer P.
Chromatin dynamics in DNA double-strand break repair.
Biochim Biophys Acta. 1819: 811-9, 2012.
5)  Burgess RC, Misteli T, Oberdoerffer P.
DNA damage, chromatin, and transcription: the trinity of aging.
Curr. Opin. Cell Biol. 24: 724-30, 2012.
6)  Shukla S, Kavak E, Gregory M, Imashimizu M, Shutinoski B, Kashlev M, Oberdoerffer P, Sandberg R, Oberdoerffer S.
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing.
Nature. 479: 74-9, 2011.
7)  Oberdoerffer P.
An age of fewer histones.
Nat. Cell Biol. 12: 1029-31, 2010.
8)  Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.
Dietary restriction: standing up for sirtuins.
Science. 329: 1012-3; author reply 1013-4, 2010.
9)  Sinclair DA, Oberdoerffer P.
The ageing epigenome: damaged beyond repair?.
Ageing Res. Rev. 8: 189-98, 2009.
10)  Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Cell. 135: 907-18, 2008.
11)  Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
PLoS ONE. 3: e2020, 2008.
12)  Oberdoerffer P, Sinclair DA.
The role of nuclear architecture in genomic instability and ageing.
Nat. Rev. Mol. Cell Biol. 8: 692-702, 2007.
13)  Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K.
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages.
Mol. Cell. Biol. 25: 3896-905, 2005.
14)  Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I.
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
J. Exp. Med. 201: 603-14, 2005.
15)  Oberdoerffer P, Novobrantseva TI, Rajewsky K.
Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements.
J. Exp. Med. 197: 1165-72, 2003.
16)  Oberdoerffer P, Otipoby KL, Maruyama M, Rajewsky K.
Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.
Nucleic Acids Res. 31: e140, 2003.
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This page was last updated on 7/28/2014.