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Our Science – Schneider Website

Joel P. Schneider, Ph.D.

Selected Publications

1)  Schneider JP.
Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties.
Nature Communications. 6: in press, 2014.
[Journal]
2)  Schneider JP, Pochan DJ, Ozbas B, Rajagopal K, Pakstis L, Kretsinger J.
Responsive hydrogels from the intramolecular folding and self-assembly of a designed peptide.
J. Am. Chem. Soc. 124: 15030-7, 2002.
[Journal]
3)  Haines-Butterick L, Rajagopal K, Branco M, Salick D, Rughani R, Pilarz M, Lamm MS, Pochan DJ, Schneider JP.
Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells.
Proc. Natl. Acad. Sci. U.S.A. 104: 7791-6, 2007.
[Journal]
4)  Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP.
Anticancer beta-Hairpin Peptides: Membrane-Induced Folding Triggers Activity.
J. Am. Chem. Soc. 134: 6210-7, 2012.
[Journal]
5)  Nagy KJ, Giano MC, Jin A, Pochan DJ, Schneider JP.
Enhanced mechanical rigidity of hydrogels formed from enantiomeric peptide assemblies.
J. Am. Chem. Soc. 133: 14975-7, 2011.
[Journal]
6)  Schneider JP.
Another year behind us.
Biopolymers. 102: vii, 2014.
[Journal]
7)  Gaspar D, Veiga AS, Sinthuvanich C, Schneider JP, Castanho MA.
Anticancer Peptide SVS-1: Efficacy Precedes Membrane Neutralization.
Biochemistry. 51: 6263-5, 2012.
[Journal]
8)  Veiga AS, Sinthuvanich C, Gaspar D, Franquelim HG, Castanho MA, Schneider JP.
Arginine-rich self-assembling peptides as potent antibacterial gels.
Biomaterials. 33: 8907-16, 2012.
[Journal]
9)  Geisler IM, Schneider JP.
Evolution Based Design of an Injectable Hydrogel.
Adv. Funct. Mater. 22: 259, 2012.
[Journal]
10)  Knerr PJ, Branco MC, Nagarkar R, Pochan DJ, Schneider JP.
Heavy Metal Ion Hydrogelation of a Self-Assembling Peptide via Cysteinyl Chelation.
J. Mater. Chem. 22: 1352, 2012.
[Journal]
11)  Yan C, Mackay ME, Czymmek K, Nagarkar RP, Schneider JP, Pochan DJ.
Injectable solid Peptide hydrogel as a cell carrier: effects of shear flow on hydrogels and cell payload.
Langmuir. 28: 6076-87, 2012.
[Journal]
12)  Sinthuvanich C, Haines-Butterick LA, Nagy KJ, Schneider JP.
Iterative design of peptide-based hydrogels and the effect of network electrostatics on primary chondrocyte behavior.
Biomaterials. 33: 7478-88, 2012.
[Journal]
13)  Giano MC, Pochan DJ, Schneider JP.
Controlled biodegradation of Self-assembling beta-hairpin Peptide hydrogels by proteolysis with matrix metalloproteinase-13.
Biomaterials. 32: 6471-7, 2011.
[Journal]
14)  Altunbas A, Lee SJ, Rajasekaran SA, Schneider JP, Pochan DJ.
Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles.
Biomaterials. 32: 5906-14, 2011.
[Journal]
15)  Smith DJ, Yap GP, Kelley JA, Schneider JP.
Enhanced stereoselectivity of a Cu(II) complex chiral auxiliary in the synthesis of Fmoc-L-gamma-carboxyglutamic acid.
J. Org. Chem. 76: 1513-20, 2011.
[Journal]
16)  Branco MC, Sigano DM, Schneider JP.
Materials from peptide assembly: towards the treatment of cancer and transmittable disease.
Curr. Opin. Chem. Biol. 15: 427-34, 2011.
[Journal]
17)  Micklitsch CM, Knerr PJ, Branco MC, Nagarkar R, Pochan DJ, Schneider JP.
Zinc-Triggered Hydrogelation of a Self-Assembling Beta-Hairpin Peptide.
Angew. Chem. Int. Ed. Engl. 50: 1577-9, 2011.
[Journal]
18)  Branco MC, Pochan DJ, Wagner NJ, Schneider JP.
The effect of protein structure on their controlled release from an injectable peptide hydrogel.
Biomaterials. 31(36): 9527-9534, 2010.
[Journal]
19)  Rughani R, Branco MC, Pochan DJ, Schneider JP.
De Novo Design of a Shear Thin Recoverable Peptide-based Hydrogel Capable of Intrafibrillar Photopolymerization.
Macromolecules. 43: 7924-7930, 2010.
[Journal]
20)  Gungormus M, Branco M, Fong H, Schneider JP, Tamerler C, Sarikaya M.
Self assembled bi-functional peptide hydrogels with biomineralization-directing peptides.
Biomaterials. 31: 7266-74, 2010.
[Journal]
21)  Yan C, Altunbas A, Yucel T, Nagarkar RP, Schneider JP, Pochan DJ.
Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable β-hairpin peptide hydrogels.
Soft Matter. 6: 5143-5156, 2010.
[Journal]
22)  Nagarkar RP, Hule RA, Pochan DJ, Schneider JP.
Domain swapping in materials design.
Biopolymers. 94: 141-55, 2010.
[Journal]
23)  Altunbas A, Sharma N, Lamm MS, Yan C, Nagarkar RP, Schneider JP, Pochan DJ.
Peptide-Silica Hybrid Networks: Biomimetic Control of Network Mechanical Behavior.
ACS Nano. 4: 181-188, 2010.
[Journal]
24)  Hule RA, Nagarkar RP, Hammouda B, Schneider JP, Pochan DJ.
Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure.
Macromolecules. 42: 7137-7145, 2009.
[Journal]
25)  Larsen TH, Branco MC, Rajagopal K, Schneider JP, Furst EM.
Sequence-dependent gelation kinetics of beta-hairpin peptide hydrogels.
Macromolecules. 42: 8443-8450, 2009.
[Journal]
26)  Rajagopal K, Lamm MS, Haines-Butterick LA, Pochan DJ, Schneider JP.
Tuning the pH Responsiveness of beta-Hairpin Peptide Folding, Self-Assembly, and Hydrogel Material Formation.
Biomacromolecules. 10: 2619-2625, 2009.
[Journal]
27)  Rughani RV, Salick DA, Lamm MS, Yucel T, Pochan DJ, Schneider JP.
Folding, self-assembly, and bulk material properties of a de novo designed three-stranded beta-sheet hydrogel.
Biomacromolecules. 10: 1295-1304, 2009.
[Journal]
28)  Salick DA, Pochan DJ, Schneider JS.
Design of an injectable beta-hairpin hydrogel that kills methicillin-resistant Staphylococcus aureus.
Adv. Mater. 21: 4120-4123, 2009.
[Journal]
29)  Branco MC, Nettesheim F, Pochan DJ, Schneider JP, Wagner NJ.
Fast dynamics of semiflexible chain networks of self-assembled peptides.
Biomacromolecules. 10: 1374-80, 2009.
[Journal]
30)  Ramadan D, Rancy PC, Nagarkar RP, Schneider JP, Thorpe C.
Arsenic(III) species inhibit oxidative protein folding in vitro.
Biochemistry. 48: 424-32, 2009.
[Journal]
31)  Branco MC, Pochan DJ, Wagner NJ, Schneider JP.
Macromolecular diffusion and release from self-assembled beta-hairpin peptide hydrogels.
Biomaterials. 30: 1339-47, 2009.
[Journal]
32)  Branco MC, Schneider JP.
Self-assembling materials for therapeutic delivery.
Acta Biomater. 5: 817-31, 2009.
[Journal]
33)  Haines-Butterick LA, Salick DA, Pochan DJ, Schneider JP.
In vitro assessment of the pro-inflammatory potential of beta-hairpin peptide hydrogels.
Biomaterials. 29: 4164-9, 2008.
[Journal]
34)  Hule RA, Nagarkar RP, Altunbas A, Ramay HR, Branco MC, Schneider JP, Pochan DJ.
Correlations between structure, material properties and bioproperties in self-assembled beta-hairpin peptide hydrogels.
Faraday Discuss. 139: 251-64; discussion 309-25, 419-20, 2008.
[Journal]
35)  Yucel T, Micklitsch CM, Schneider JP, Pochan DJ.
Direct Observation of Early-Time Hydrogelation in beta-Hairpin Peptide Self-Assembly.
Macromolecules. 41: 5763-5772, 2008.
[Journal]
36)  Nagarkar RP, Schneider JP.
Synthesis and primary characterization of self-assembled peptide-based hydrogels.
Methods Mol. Biol. 474: 61-77, 2008.
[Journal]
37)  Rughani RV, Schneider JP.
Molecular Design of beta-Hairpin Peptides for Material Construction.
MRS Bull. 33: 530-535, 2008.
[Journal]
38)  Lamm MS, Sharma N, Beyer FL, Schneider JP, Pochan DJ.
Laterally spaced linear nanoparticle arrays templated by laminated beta-sheet fibrils.
Adv. Mater. 20: 447-451, 2008.
[Journal]
39)  Nagarkar RP, Hule RA, Pochan DJ, Schneider JP.
De novo design of strand-swapped beta-hairpin hydrogels.
J. Am. Chem. Soc. 130: 4466-74, 2008.
[Journal]
40)  Ozbas B, Rajagopal K, Haines-Butterick L, Schneider JP, Pochan DJ.
Reversible stiffening transition in beta-hairpin hydrogels induced by ion complexation.
J Phys Chem B. 111: 13901-8, 2007.
[Journal]
41)  Salick DA, Kretsinger JK, Pochan DJ, Schneider JP.
Inherent antibacterial activity of a peptide-based beta-hairpin hydrogel.
J. Am. Chem. Soc. 129: 14793-9, 2007.
[Journal]
42)  Capriotti LA, Beebe TP, Schneider JP.
Hydroxyapatite surface-induced peptide folding.
J. Am. Chem. Soc. 129: 5281-7, 2007.
[Journal]
43)  Ramadan D, Cline DJ, Bai S, Thorpe C, Schneider JP.
Effects of As(III) binding on beta-hairpin structure.
J. Am. Chem. Soc. 129: 2981-8, 2007.
[Journal]
44)  Basu A, Schneider J.
Model Systems.
Curr. Opin. Chem. Biol. 10: 527-528, 2006.
[Journal]
45)  Ozbas B, Schneider JP, Pochan DJ.
Fishman ML, Qi PX, Wicker L, eds.
Hydrogels Constructed via beta-Hairpin Peptide Self-Assembly. In: Advances in Biopolymers: Molecules, Clusters, Networks, and Interactions.
Washington, DC: An American Chemical Society Publication; 2006. p. 284 [Book Chapter]
46)  Veerman C, Rajagopal K, Palla C, Pochan D, Schneider JP, Furst EM.
Gelation kinetics of beta-hairpin peptide hydrogel networks.
Macromolecules. 39: 6608-6614, 2006.
[Journal]
47)  Micklitsch CM, Yu Q, Schneider JP.
Unnatural multidentate metal ligating alpha-amino acids.
Tetrahedron Lett. 47: 6277-6280, 2006.
[Journal]
48)  Di­az DD, Rajagopal K, Strable E, Schneider J, Finn MG.
'Click' chemistry in a supramolecular environment: stabilization of organogels by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.
J. Am. Chem. Soc. 128: 6056-7, 2006.
[Journal]
49)  Rajagopal K, Ozbas B, Pochan DJ, Schneider JP.
Probing the importance of lateral hydrophobic association in self-assembling peptide hydrogelators.
Eur. Biophys. J. 35: 162-9, 2006.
[Journal]
50)  Haines LA, Rajagopal K, Ozbas B, Salick DA, Pochan DJ, Schneider JP.
Light-activated hydrogel formation via the triggered folding and self-assembly of a designed peptide.
J. Am. Chem. Soc. 127: 17025-9, 2005.
[Journal]
51)  Lamm MS, Rajagopal K, Schneider JP, Pochan DJ.
Laminated morphology of nontwisting beta-sheet fibrils constructed via peptide self-assembly.
J. Am. Chem. Soc. 127: 16692-700, 2005.
[Journal]
52)  Kretsinger JK, Haines LA, Ozbas B, Pochan DJ, Schneider JP.
Cytocompatibility of self-assembled beta-hairpin peptide hydrogel surfaces.
Biomaterials. 26: 5177-86, 2005.
[Journal]
53)  Cline DJ, Redding SE, Brohawn SG, Psathas JN, Schneider JP, Thorpe C.
New water-soluble phosphines as reductants of peptide and protein disulfide bonds: reactivity and membrane permeability.
Biochemistry. 43: 15195-203, 2004.
[Journal]
54)  Cline DJ, Schneider JP, Thorpe C, Yap GP.
1-Benzylsulfanyl-2-(benzylsulfanylmethyl)-propanaminium chloride.
Acta Cryst. E60: O1972-O1974, 2004.
[Journal]
55)  Ozbas B, Rajagopal K, Schneider JP, Pochan DJ.
Semiflexible chain networks formed via self-assembly of beta-hairpin molecules.
Phys. Rev. Lett. 93: 268106, 2004.
[Journal]
56)  Lee K, Dzubeck V, Latshaw L, Schneider JP.
De novo designed peptidic redox potential probe: linking sensitized emission to disulfide bond formation.
J. Am. Chem. Soc. 126: 13616-7, 2004.
[Journal]
57)  Ozbas B, Kretsinger J, Rajagopal K, Schneider JP, Pochan DJ.
Salt-triggered peptide folding and consequent self-assembly into hydrogels with tunable modulus.
Macromolecules. 37: 7331-7337, 2004.
[Journal]
58)  Cline DJ, Thorpe C, Schneider JP.
General method for facile intramolecular disulfide formation in synthetic peptides.
Anal. Biochem. 335: 168-70, 2004.
[Journal]
59)  Rajagopal K, Schneider JP.
Self-assembling peptides and proteins for nanotechnological applications.
Curr. Opin. Struct. Biol. 14: 480-6, 2004.
[Journal]
60)  Cline DJ, Thorpe C, Schneider JP.
Structure-based design of a fluorimetric redox active peptide probe.
Anal. Biochem. 325: 144-50, 2004.
[Journal]
61)  Pochan DJ, Schneider JP, Kretsinger J, Ozbas B, Rajagopal K, Haines L.
Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de novo designed peptide.
J. Am. Chem. Soc. 125: 11802-3, 2003.
[Journal]
62)  Kretsinger JK, Schneider JP.
Design and application of basic amino acids displaying enhanced hydrophobicity.
J. Am. Chem. Soc. 125: 7907-13, 2003.
[Journal]
63)  Cline DJ, Thorpe C, Schneider JP.
Effects of As(III) binding on alpha-helical structure.
J. Am. Chem. Soc. 125: 2923-9, 2003.
[Journal]
64)  Gill JK, Schneider JP.
Conformational uniqueness via designed ion pairs (Proceedings of the 17th American Peptide Symposium).
Lebl M, Houghten RA, eds.
. p. 438. [Meeting Proceeding]
65)  Dzubeck V, Schneider JP.
One-pot conversion of benzyl carbamates into fluorenylmethyl carbamates.
Tetrahedron Lett. 41: 9953-9956, 2000.
[Journal]
66)  Hamuro Y, Schneider JP, DeGrado WF.
De Novo Design of Antibacterial beta-Peptides.
J. Am. Chem. Soc. 121: 12200-12201, 1999.
[Journal]
67)  Moran LB, Schneider JP, Kentsis A, Reddy GA, Sosnick TR.
Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking.
Proc. Natl. Acad. Sci. U.S.A. 96: 10699-704, 1999.
[Journal]
68)  DeGrado WF, Schneider JP, Hamuro Y.
The twists and turns of beta-peptides.
J. Pept. Res. 54: 206-17, 1999.
[Journal]
69)  Schneider JP, DeGrado WF.
The Design of Efficient alpha-helical C-Capping Auxiliaries.
J. Am. Chem. Soc. 120: 2764-2767, 1998.
[Journal]
70)  Schneider JP, Lombardi A, DeGrado WF.
Analysis and design of three-stranded coiled coils and three-helix bundles.
Fold Des. 3: R29-40, 1998.
[Journal]
71)  Schneider JP, Lear JD, DeGrado WF.
A Designed Buried Salt Bridge in a Heterodimeric Coiled Coil.
J. Am. Chem. Soc. 119: 5742-5743, 1997.
[Journal]
72)  Lear JD, Kienker PK, DeGrado WF.
Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides.
J. Am. Chem. Soc. 119: 3212-3217, 1997.
[Journal]
73)  Choo DW, Schneider JP, Graciani NR, Kelly JW.
A Nucleated Antiparallel beta-Sheet That Folds and Undergoes Self-Assembly.
Macromolecules. 29: 355-366, 1996.
[Journal]
74)  Schneider JP, Kelly JW.
Synthesis and Efficacy of Square Planar Metal Complexes Designed to Nucleate beta-Sheet Structure.
FASEB J. 9: A1429-A1429, 1995.
[Journal]
75)  Schneider JP, Kelly JW.
Synthesis and Efficacy of Square Planar Copper Complexes Designed to Nucleate alpha-Sheet Secondary Structure.
J. Am. Chem. Soc. 117: 2533-2546, 1995.
[Journal]
76)  Schneider JP, Kelly JW.
Templates That Induce alpha-helical, beta-sheet, and Omega loop Conformations.
Chem. Rev. 95: 2169-2187, 1995.
[Journal]
77)  Schneider JP, Topgi RS, Kelly JW.
A Convenient Synthesis of 6,6'-Diamino-2,2'-Bipyridine.
Synth. Commun. 22: 1033-1037, 1992.
[Journal]
78)  Veiga AS, Schneider JP.
Antimicrobial hydrogels for the treatment of infection.
Biopolymers. 2013.
[Journal]
79)  Gupta K, Jang H, Harlen K, Puri A, Nussinov R, Schneider JP, Blumenthal R.
Mechanism of Membrane Permeation Induced by Synthetic beta-Hairpin Peptides.
Biophys. J. 105: 2093-103, 2013.
[Journal]
80)  Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH.
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Retrovirology. 9: 99, 2012.
[Journal]
81)  Micklitsch CM, Knerr PJ, Branco MC, Nagarkar R, Pochan DJ, Schneider JP.
Zinc-Triggered Hydrogelation of a Self-Assembling beta-Hairpin Peptide.
Angew. Chem. Int. Ed. Engl. 50: 1577-9, 2011.
[Journal]
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This page was last updated on 6/18/2014.