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Michael A. Tangrea, Ph.D.

Selected Publications

1)  Chen Y, Dodd SJ, Tangrea MA, Emmert-Buck MR, Koretsky AP.
Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging.
Sci Rep. 3: 1879, 2013.
2)  Rodriguez-Canales J, Hanson JC, Hipp JD, Balis UJ, Tangrea MA, Emmert-Buck MR, Bova GS.
Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications.
Methods Mol. Biol. 980: 61-120, 2013.
3)  Mukherjee S, Rodriguez-Canales J, Hanson J, Emmert-Buck MR, Tangrea MA, Prieto DA, Blonder J, Johann DJ.
Proteomic analysis of frozen tissue samples using laser capture microdissection.
Methods Mol. Biol. 1002: 71-83, 2013.
4)  Blackler AR, Morgan NY, Gao B, Olano LR, Armani MD, Romantseva E, Kakareka JW, Bonner RF, Mukherjee S, Xiao B, Tran K, Pohida TJ, Emmert-Buck MR, Tangrea MA, Markey SP.
Proteomic analysis of nuclei dissected from fixed rat brain tissue using expression microdissection.
Anal. Chem. 85: 7139-45, 2013.
5)  Yan W, Shih J, Rodriguez-Canales J, Tangrea MA, Player A, Diao L, Hu N, Goldstein AM, Wang J, Taylor PR, Lippman SM, Wistuba II, Emmert-Buck MR, Erickson HS.
Three-dimensional mRNA measurements reveal minimal regional heterogeneity in esophageal squamous cell carcinoma.
Am. J. Pathol. 182: 529-39, 2013.
6)  Du Q, Yan W, Burton VH, Hewitt SM, Wang L, Hu N, Taylor PR, Armani MD, Mukherjee S, Emmert-Buck MR, Tangrea MA.
Validation of esophageal squamous cell carcinoma candidate genes from high-throughput transcriptomic studies.
Am J Cancer Res. 3: 402-10, 2013.
7)  Yan W, Shih JH, Rodriguez-Canales J, Tangrea MA, Ylaya K, Hipp J, Player A, Hu N, Goldstein AM, Taylor PR, Emmert-Buck MR, Erickson HS.
Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma.
BMC Res Notes. 5: 73, 2012.
8)  Nacev A, Kim SH, Rodriguez-Canales J, Tangrea MA, Shapiro B, Emmert-Buck MR.
A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens.
Int J Nanomedicine. 6: 2907-23, 2011.
9)  Deeb KK, Luo W, Karpf AR, Omilian AR, Bshara W, Tian L, Tangrea MA, Morrison CD, Johnson CS, Trump DL.
Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate.
Epigenetics. 6: 994-1000, 2011.
10)  Tangrea M, Mukherjee S, Gao B, Markey SP, Du Q, Armani M, Kreitman MS, Rosenberg AM, Wallis BS, Eberle FC, Duncan FC, Hanson JC, Chuaqui RF, Rodriguez-Canales J, Emmert-Buck MR.
Effect of Immunohistochemistry on Molecular Analysis of Tissue Samples: Implications for Microdissection Technologies.
J Histochem Cytochem. 59: 591-600, 2011.
11)  Hanson JC, Tangrea MA, Kim S, Armani MD, Pohida TJ, Bonner RF, Rodriguez-Canales J, Emmert-Buck MR.
Expression microdissection adapted to commercial laser dissection instruments.
Nat Protoc. 6: 457-67, 2011.
12)  Tangrea MA, Hanson JC, Bonner RF, Pohida TJ, Rodriguez-Canales J, Emmert-Buck MR.
Immunoguided microdissection techniques.
Methods Mol. Biol. 755: 57-66, 2011.
13)  Zhu L, Tangrea MA, Mukherjee S, Emmert-Buck MR.
Layered electrophoretic transfer - A method for pre-analytic processing of histological sections.
Proteomics. 11: 883-9, 2011.
14)  Zhu L, Yan W, Rodriguez-Canales J, Rosenberg AM, Hu N, Goldstein AM, Taylor PR, Erickson HS, Emmert-Buck MR, Tangrea MA.
MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells.
Am J Cancer Res. 1: 574-584, 2011.
15)  Armani M, Tangrea MA, Shapiro B, Emmert-Buck MR, Smela E.
Quantifying mRNA levels across tissue sections with 2D-RT-qPCR.
Anal Bioanal Chem. 400: 3383-93, 2011.
16)  Hipp J, Cheng J, Hanson JC, Yan W, Taylor P, Hu N, Rodriguez-Canales J, Hipp J, Tangrea MA, Emmert-Buck MR, Balis U.
SIVQ-aided laser capture microdissection: A tool for high-throughput expression profiling.
J Pathol Inform. 2: 19, 2011.
17)  Erickson HS, Gannot G, Tangrea MA, Chuaqui RF, Gillespie JW, Emmert-Buck MR.
High throughput screening of normal and neoplastic tissue samples.
Comb. Chem. High Throughput Screen. 13: 253-67, 2010.
18)  Mukherjee S, Roth MJ, Dawsey SM, Yan W, Rodriguez-Canales J, Erickson HS, Hu N, Goldstein AM, Taylor PR, Richardson AM, Tangrea MA, Chuaqui RF, Emmert-Buck MR.
Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma.
Journal of translational medicine. 8: 91, 2010.
19)  Armani M, Rodriguez-Canales J, Gillespie J, Tangrea M, Erickson H, Emmert-Buck MR, Shapiro B, Smela E.
2D-PCR: a method of mapping DNA in tissue sections.
Lab Chip. 9: 3526-34, 2009.
20)  Zoon CK, Starker EQ, Wilson AM, Emmert-Buck MR, Libutti SK, Tangrea MA.
Current molecular diagnostics of breast cancer and the potential incorporation of microRNA.
Expert Rev. Mol. Diagn. 9: 455-67, 2009.
21)  Blansfield JA, Caragacianu D, Alexander HR, Tangrea MA, Morita SY, Lorang D, Schafer P, Muller G, Stirling D, Royal RE, Libutti SK.
Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy.
Clin. Cancer Res. 14: 270-80, 2008.
22)  Richardson AM, Woodson K, Wang Y, Rodriguez-Canales J, Erickson HS, Tangrea MA, Novakovic K, Gonzalez S, Velasco A, Kawasaki ES, Emmert-Buck MR, Chuaqui RF, Player A.
Global expression analysis of prostate cancer-associated stroma and epithelia.
Diagn. Mol. Pathol. 16: 189-97, 2007.
23)  Rodriguez-Canales J, Hanson JC, Tangrea MA, Erickson HS, Albert PS, Wallis BS, Richardson AM, Pinto PA, Linehan WM, Gillespie JW, Merino MJ, Libutti SK, Woodson KG, Emmert-Buck MR, Chuaqui RF.
Identification of a unique epigenetic sub-microenvironment in prostate cancer.
J. Pathol. 211: 410-9, 2007.
24)  Gannot G, Tangrea MA, Richardson AM, Flaig MJ, Hewitt SM, Marcus EM, Emmert-Buck MR, Chuaqui RF.
Layered expression scanning: multiplex molecular analysis of diverse life science platforms.
Clin. Chim. Acta. 376: 9-16, 2007.
25)  Gannot G, Tangrea MA, Erickson HS, Pinto PA, Hewitt SM, Chuaqui RF, Gillespie JW, Emmert-Buck MR.
Layered peptide array for multiplex immunohistochemistry.
J Mol Diagn. 9: 297-304, 2007.
26)  Gannot G, Tangrea MA, Chuaqui RF, Gillespie JW, Emmert-Buck MR.
Layered peptide arrays: a diverse technique for antibody screening of clinical samples.
Ann. N. Y. Acad. Sci. 1098: 451-3, 2007.
27)  Hanson JA, Gillespie JW, Grover A, Tangrea MA, Chuaqui RF, Emmert-Buck MR, Tangrea JA, Libutti SK, Linehan WM, Woodson KG.
Gene promoter methylation in prostate tumor-associated stromal cells.
J. Natl. Cancer Inst. 98: 255-61, 2006.
28)  Grover AC, Tangrea MA, Woodson KG, Wallis BS, Hanson JC, Chuaqui RF, Gillespie JW, Erickson HS, Bonner RF, Pohida TJ, Emmert-Buck MR, Libutti SK.
Tumor-associated endothelial cells display GSTP1 and RARbeta2 promoter methylation in human prostate cancer.
J Transl Med. 4: 13, 2006.
29)  Gannot G, Gillespie JW, Chuaqui RF, Tangrea MA, Linehan WM, Emmert-Buck MR.
Histomathematical analysis of clinical specimens: challenges and progress.
J. Histochem. Cytochem. 53: 177-85, 2005.
30)  Gannot G, Tangrea MA, Gillespie JW, Erickson HS, Wallis BS, Leakan RA, Knezevic V, Hartmann DP, Chuaqui RF, Emmert-Buck MR.
Layered peptide arrays: high-throughput antibody screening of clinical samples.
J Mol Diagn. 7: 427-36, 2005.
31)  Best CJ, Gillespie JW, Yi Y, Chandramouli GV, Perlmutter MA, Gathright Y, Erickson HS, Georgevich L, Tangrea MA, Duray PH, González S, Velasco A, Linehan WM, Matusik RJ, Price DK, Figg WD, Emmert-Buck MR, Chuaqui RF.
Molecular alterations in primary prostate cancer after androgen ablation therapy.
Clin. Cancer Res. 11: 6823-34, 2005.
32)  Tangrea MA, Chuaqui RF, Gillespie JW, Ahram M, Gannot G, Wallis BS, Best CJ, Linehan WM, Liotta LA, Pohida TJ, Bonner RF, Emmert-Buck MR.
Expression microdissection: operator-independent retrieval of cells for molecular profiling.
Diagn. Mol. Pathol. 13: 207-12, 2004.
33)  Gillespie JW, Gannot G, Tangrea MA, Ahram M, Best CJ, Bichsel VE, Petricoin EF, Emmert-Buck MR, Chuaqui RF.
Molecular profiling of cancer.
Toxicol Pathol. 32 Suppl 1: 67-71, 2004.
34)  Tangrea MA, Wallis BS, Gillespie JW, Gannot G, Emmert-Buck MR, Chuaqui RF.
Novel proteomic approaches for tissue analysis.
Expert review of proteomics. 1: 185-92, 2004.
35)  Tangrea MA, Flaig MJ, Ramesh A, Best CJ, Baibakov GV, Hewitt SM, Mitchell CD, Hartmann DP, Knezevic V, Emmert-Buck MR, Chuaqui RF.
Layered expression scanning: multiplex analysis of RNA and protein gels.
BioTechniques. 35: 1280-5, 2003.
36)  Chuaqui RF, Bonner RF, Best CJ, Gillespie JW, Flaig MJ, Hewitt SM, Phillips JL, Krizman DB, Tangrea MA, Ahram M, Linehan WM, Knezevic V, Emmert-Buck MR.
Post-analysis follow-up and validation of microarray experiments.
Nat. Genet. 32 Suppl: 509-14, 2002.
37)  Tangrea MA, Bryan PN, Sari N, Orban J.
Solution structure of the pro-hormone convertase 1 pro-domain from Mus musculus.
J. Mol. Biol. 320: 801-12, 2002.
38)  Tangrea MA, Alexander P, Bryan PN, Eisenstein E, Toedt J, Orban J.
Stability and global fold of the mouse prohormone convertase 1 pro-domain.
Biochemistry. 40: 5488-95, 2001.
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This page was last updated on 4/15/2014.