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Our Science – Tropea Website

Joseph E. Tropea, Ph.D.

Selected Publications

1)  Shaw GX, Li Y, Shi G, Wu Y, Cherry S, Needle D, Zhang D, Tropea JE, Waugh DS, Yan H, Ji X.
Structural enzymology and inhibition of the bifunctional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
FEBS J. [Epub ahead of print], 2014.
2)  Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M.
Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300.
Acta Crystallogr. D Biol. Crystallogr. 70: 1914-21, 2014.
3)  Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR, Waugh DS, Ulrich RG.
Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase.
Chem Biol Drug Des. 81: 323-33, 2013.
4)  Raran-Kurussi S, Tözsér J, Cherry S, Tropea JE, Waugh DS.
Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases.
Anal. Biochem. 436: 142-4, 2013.
5)  Court DL, Gan J, Liang YH, Shaw GX, Tropea JE, Costantino N, Waugh DS, Ji X.
RNase III: Genetics and function; structure and mechanism.
Annu. Rev. Genet. 47: 405-31, 2013.
6)  Lountos GT, Tropea JE, Waugh DS.
Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas" disease.
Mol. Biochem. Parasitol. 187: 1-8, 2013.
7)  Lountos GT, Tropea JE, Waugh DS.
Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system.
Acta Crystallogr. D Biol. Crystallogr. 68: 201-9, 2012.
8)  Sun P, Tropea JE, Waugh DS.
Enhancing the solubility of recombinant proteins in Escherichia coli by using hexahistidine-tagged maltose-binding protein as a fusion partner.
Methods Mol. Biol. 705: 259-74, 2011.
9)  Lountos GT, Jobson AG, Tropea JE, Self CR, Zhang G, Pommier Y, Shoemaker RH, Waugh DS.
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.
J. Struct. Biol. 176: 292-301, 2011.
10)  Lountos GT, Tropea JE, Waugh DS.
Structure of human dual-specificity phosphatase 27 at 2.38 angstrom resolution.
Acta Crystallogr. D Biol. Crystallogr. 67: 471-9, 2011.
Click Here to View Expanded Bibliography.

This page was last updated on 7/22/2014.