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Our Science – Lewis Website

Brian A. Lewis, Ph.D.

Selected Publications

1)  Devaiah BN, Lewis BA, Cherman N, Hewitt MC, Albrecht BK, Robey PG, Ozato K, Sims RJ, Singer DS.
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain.
Proc. Natl. Acad. Sci. U.S.A. 109: 6927-32, 2012.
2)  Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA.
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.
J Biol Chem. 287: 23549-61, 2012.
3)  Ranuncolo SM, Pittaluga S, Evbuomwan MO, Jaffe ES, Lewis BA.
Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival.
Blood. 120: 3756-63, 2012.
4)  Lee N, Iyer SS, Mu J, Weissman JD, Ohali A, Howcroft TK, Lewis BA, Singer DS.
Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells.
PLoS ONE. 5: e15278, 2010.
5)  Lewis BA.
Understanding large multiprotein complexes: applying a multiple allosteric networks model to explain the function of the Mediator transcription complex.
J. Cell. Sci. 123: 159-63, 2010.
6)  Sims RJ, Millhouse S, Chen CF, Lewis BA, Erdjument-Bromage H, Tempst P, Manley JL, Reinberg D.
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
Mol. Cell. 28: 665-76, 2007.
7)  Lewis BA, Reinberg D.
Promoter activation when the ChIPs are down.
Nat. Struct. Mol. Biol. 13: 96-7, 2006.
8)  Lewis BA, Sims RJ, Lane WS, Reinberg D.
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator.
Mol. Cell. 18: 471-81, 2005.
9)  Lee DH, Gershenzon N, Gupta M, Ioshikhes IP, Reinberg D, Lewis BA.
Functional characterization of core promoter elements: the downstream core element is recognized by TAF1.
Mol. Cell. Biol. 25: 9674-86, 2005.
10)  Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D.
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.
Mol. Cell. 18: 83-96, 2005.
Click Here to View Expanded Bibliography.

This page was last updated on 4/18/2013.