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Our Science – Oppenheim Website

Joost J. Oppenheim, M.D.

Selected Publications

1)  Yang D, Postnikov YV, Li Y, Tewary P, de la Rosa G, Wei F, Klinman D, Gioannini T, Weiss JP, Furusawa T, Bustin M, Oppenheim JJ.
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
J. Exp. Med. 209: 157-71, 2012.
2)  Yoshimura T, Oppenheim JJ.
Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties.
Exp. Cell Res. 317: 674-84, 2011.
3)  Chen X, Oppenheim JJ.
Comment on.
J. Immunol. 187: 1527; author reply 1527-8, 2011.
4)  Chen X, Oppenheim JJ.
Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity.
FEBS Lett. 3611-8, 2011.
5)  Buzas K, Oppenheim JJ, Zack Howard OM.
Myeloid cells migrate in response to IL-24.
Cytokine. 55: 429-34, 2011.
6)  Chertov O, Zhang N, Chen X, Oppenheim JJ, Lubkowski J, McGrath C, Sowder RC, Crise BJ, Malyguine A, Kutzler MA, Steele AD, Henderson EE, Rogers TJ.
Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.
PLoS ONE. 6: e14474, 2011.
7)  Qi J, Buzas K, Fan H, Cohen JI, Wang K, Mont E, Klinman D, Oppenheim JJ, Howard OM.
Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons.
J Immunol. 6417-26, 2011.
8)  Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ.
PKC{zeta} mediates {micro}-opioid receptor-induced cross-desensitization of CCR5.
J Biol Chem. 20354-65, 2011.
9)  Chen X, Oppenheim JJ.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Int. Immunopharmacol. 11: 1489-96, 2011.
10)  Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.
Proc. Natl. Acad. Sci. U.S.A. 108: 9798-803, 2011.
11)  Chen X, Oppenheim JJ.
The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.
Immunology. 133: 426-33, 2011.
12)  Hamano R, Huang J, Yoshimura T, Oppenheim JJ, Chen X.
TNF by inducing co-stimulatory TNF receptor superfamily members TNFR2, 4-1BB and OX40 augments the number and function of mouse CD4(+) FoxP3(+) regulatory T cells.
Eur J Immunol. 2010-20, 2011.
13)  Yang D, Zhao Y, Guo H, Li Y, Tewary P, Xing G, Hou W, Oppenheim JJ, Zhang N.
[Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses.
ACS Nano. 4: 1178-86, 2010.
14)  Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, Oppenheim JJ.
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.
Eur. J. Immunol. 40: 1099-106, 2010.
15)  Chen X, Hamano R, Subleski JJ, Hurwitz AA, Howard OM, Oppenheim JJ.
Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.
J. Immunol. 185: 174-82, 2010.
16)  Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, Clayberger C, Oppenheim JJ.
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.
Blood. 116: 3465-74, 2010.
17)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
J. Immunol. 184: 6688-94, 2010.
18)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
J. Biol. Chem. 285: 7028-34, 2010.
19)  Chen X, Oppenheim JJ.
TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.
Curr. Dir. Autoimmun. 11: 119-34, 2010.
20)  Yang D, Oppenheim JJ.
Alarmins and antimicrobial immunity.
Med. Mycol. 47 Suppl 1: S146-53, 2009.
21)  Yang D, de la Rosa G, Tewary P, Oppenheim JJ.
Alarmins link neutrophils and dendritic cells.
Trends Immunol. 30: 531-7, 2009.
22)  Yang D, Tewary P, de la Rosa G, Wei F, Oppenheim JJ.
The alarmin functions of high-mobility group proteins.
Biochim. Biophys. Acta. 1799: 157-63, 2009.
23)  Yoshimura T, Oppenheim JJ.
Chemerin reveals its chimeric nature.
J. Exp. Med. 205: 2187-90, 2008.
24)  Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.
J. Immunol. 181: 1499-506, 2008.
25)  Chen X, Subleski JJ, Kopf H, Howard OM, Männel DN, Oppenheim JJ.
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
J. Immunol. 180: 6467-71, 2008.
26)  Yang D, Chen Q, Su SB, Zhang P, Kurosaka K, Caspi RR, Michalek SM, Rosenberg HF, Zhang N, Oppenheim JJ.
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.
J. Exp. Med. 205: 79-90, 2008.
27)  Röhrl J, Yang D, Oppenheim JJ, Hehlgans T.
Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3.
J. Biol. Chem. 283: 5414-9, 2008.
28)  de la Rosa G, Yang D, Tewary P, Varadhachary A, Oppenheim JJ.
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses.
J. Immunol. 180: 6868-76, 2008.
29)  Rosenberg HF, Oppenheim JJ.
The 2007 Dolph Adams Award and the state of the Journal of Leukocyte Biology.
J. Leukoc. Biol. 83: 227-8, 2008.
30)  Oppenheim JJ, Tewary P, de la Rosa G, Yang D.
Alarmins initiate host defense.
Adv. Exp. Med. Biol. 601: 185-94, 2007.
31)  Yang D, Liu ZH, Tewary P, Chen Q, de la Rosa G, Oppenheim JJ.
Defensin participation in innate and adaptive immunity.
Curr. Pharm. Des. 13: 3131-9, 2007.
32)  Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, Oppenheim JJ.
High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin.
J. Leukoc. Biol. 81: 59-66, 2007.
33)  Oppenheim JJ.
IL-2: more than a T cell growth factor.
J. Immunol. 179: 1413-4, 2007.
34)  Hu PQ, Hurwitz AA, Oppenheim JJ.
Immunization with DNA topoisomerase I induces autoimmune responses but not scleroderma-like pathologies in mice.
J. Rheumatol. 34: 2243-52, 2007.
35)  Chen X, Bäumel M, Männel DN, Howard OM, Oppenheim JJ.
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.
J. Immunol. 179: 154-61, 2007.
36)  Chen X, Howard OM, Oppenheim JJ.
Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.
J. Immunol. 178: 6123-9, 2007.
37)  Liu Y, Sun R, Wan W, Wang J, Oppenheim JJ, Chen L, Zhang N.
The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells.
Mol. Membr. Biol. 24: 91-101, 2007.
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This page was last updated on 5/14/2012.