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Our Science – Huang Website

Jing Huang, Ph.D.

Selected Publications

1)  Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT.
Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.
Nat Commun. 5: 3365, 2014.
2)  Shin M, He Y, Huang J.
Embryonic stem cells shed new light on the developmental roles of p53.
Cell Biosci. 3: 42, 2013.
3)  Zhang X, He Y, Lee K, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J.
Rap2b, a novel p53 target, regulates p53-mediated pro-survival function.
Cell Cycle. 12: 1279-91, 2013.
4)  Li M, He Y, Dubois W, Wu X, Shi J, Huang J.
Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells.
Molecular Cell. 30-42, 2012.
5)  Li M, He Y, Feng X, Huang J.
Genome-wide studies of the transcriptional regulation by p53.
Biochim Biophys Acta. 1819: 684-7, 2012.
6)  He Y, Korboukh I, Jin J, Huang J.
Targeting protein lysine methylation and demethylation in cancers.
Acta Biochim. Biophys. Sin. (Shanghai). 44: 70-9, 2012.
7)  Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Martin M, Chen X, Yates C, Frye S, Brown P, Huang J, Vedadi M, Arrowsmith C, Jin J.
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines.
J Med Chem. 8: 6139, 2011.
8)  Lee KH, Li M, Michalowski AM, Zhang X, Liao H, Chen L, Xu Y, Wu X, Huang J.
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells.
Proc. Natl. Acad. Sci. U.S.A. 107: 69-74, 2010.
9)  Li M, Huang J.
A new puzzling role of p53 in mouse embryonic stem cells.
Cell Cycle. 9: 1669-70, 2010.
Full Text Article. [Journal]
10)  Huang J, Dorsey J, Chuikov S, Zhang X, Jenuwein T, Reinberg D, Berger SL.
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
J. Biol. Chem. 285: 9636-41, 2010.
11)  Zhang X, Huang J.
Integrative genome-wide approaches in embryonic stem cell research.
Integr Biol (Camb). 2: 510-6, 2010.
Full Text Article. [Journal]
12)  Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B, Chance MR, Chen X, Du Y, Wang Y, An L, Wang Q, Lu T, Zhang X, Wang Z, Stark GR.
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.
Proc. Natl. Acad. Sci. U.S.A. 107: 21499-504, 2010.
13)  Placek BJ, Huang J, Kent JR, Dorsey J, Rice L, Fraser NW, Berger SL.
The histone variant H3.3 regulates gene expression during lytic infection by Herpes Simplex Virus, HSV-1.
J. Virol. 83(3): 1416, 2008.
14)  Huang J, Berger SL.
The emerging field of dynamic lysine methylation of non-histone proteins.
Curr. Opin. Genet. Dev. 18: 152-8, 2008.
15)  Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL.
p53 is regulated by the lysine demethylase LSD1.
Nature. 449: 105-8, 2007.
16)  Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.
Genes Dev. 22: 2664-76, 2008.
17)  Chen Q, Lin L, Smith S, Huang J, Berger SL, Zhou J.
CTCF-dependent chromatin boundary element between the latency-associated transcript and ICP0 promoters in the herpes simplex virus type 1 genome.
J. Virol. 81: 5192-201, 2007.
18)  Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL.
Repression of p53 activity by Smyd2-mediated methylation.
Nature. 444: 629-32, 2006.
19)  Huang J, Kent JR, Placek B, Whelan KA, Hollow CM, Zeng PY, Fraser NW, Berger SL.
Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.
J. Virol. 80: 5740-6, 2006.
20)  Huang J, Li X, Qiao T, Bambara RA, Hilf R, Muyan M.
A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses.
Nucl Recept Signal. 4: e015, 2006.
21)  Huang J, Li X, Maguire CA, Hilf R, Bambara RA, Muyan M.
Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus.
Mol. Endocrinol. 19: 2696-712, 2005.
22)  Huang J, Li X, Hilf R, Bambara RA, Muyan M.
Molecular basis of therapeutic strategies for breast cancer.
Curr. Drug Targets Immune Endocr. Metabol. Disord. 5: 379-96, 2005.
23)  Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M.
Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways.
Mol. Cell. Biol. 24: 7681-94, 2004.
24)  Huang J, Li X, Yi P, Hilf R, Bambara RA, Muyan M.
Targeting estrogen responsive elements (EREs): design of potent transactivators for ERE-containing genes.
Mol. Cell. Endocrinol. 218: 65-78, 2004.
25)  Yi P, Driscoll MD, Huang J, Bhagat S, Hilf R, Bambara RA, Muyan M.
The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta.
Mol. Endocrinol. 16: 674-93, 2002.
26)  Li X, Huang J, Fluharty BR, Huang Y, Nott SL, Muyan M.
What are comparative studies telling us about the mechanism of ERbeta action in the ERE-dependent E2 signaling pathway?.
J. Steroid Biochem. Mol. Biol. 109: 266-72, 2008.
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This page was last updated on 5/2/2014.