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Our Science – Salcedo Website

Rosalba Salcedo, Ph.D.

Selected Publications

1)  Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
Science. 342: 967-70, 2013.
[Journal]
2)  Golubeva Y, Salcedo R, Mueller C, Liotta LA, Espina V.
Laser capture microdissection for protein and NanoString RNA analysis.
Methods Mol. Biol. 931: 213-57, 2013.
[Journal]
3)  Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G.
MyD88 and its divergent toll in carcinogenesis.
Trends Immunol. 34: 379-89, 2013.
[Journal]
4)  Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y.
Compartmentalized control of skin immunity by resident commensals.
Science. 337: 1115-9, 2012.
[Journal]
5)  Stauffer JK, Orentas RJ, Lincoln E, Khan T, Salcedo R, Hixon JA, Back TC, Wei JS, Patidar R, Song Y, Hurd L, Tsokos M, Lai EW, Eisenhofer G, Weiss W, Khan J, Wigginton JM.
High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.
Cancer Invest. 30: 343-63, 2012.
[Journal]
6)  Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.
J. Exp. Med. 209: 1689-702, 2012.
[Journal]
7)  Young GR, Eksmond U, Salcedo R, Alexopoulou L, Stoye JP, Kassiotis G.
Resurrection of endogenous retroviruses in antibody-deficient mice.
Nature. 491: 774-8, 2012.
[Journal]
8)  Wu J, Li J, Salcedo R, Mivechi NF, Trinchieri G, Horuzsko A.
The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma.
Cancer Res. 72: 3977-86, 2012.
[Journal]
9)  Garg H, Salcedo R, Trinchieri G, Blumenthal R.
Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax.
Cancer Gene Ther. 17: 155-63, 2010.
[Journal]
10)  Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
J. Exp. Med. 207: 1625-36, 2010.
[Journal]
11)  Sangaletti S, Tripodo C, Ratti C, Piconese S, Porcasi R, Salcedo R, Trinchieri G, Colombo MP, Chiodoni C.
Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis.
Cancer Res. 70: 7764-75, 2010.
[Journal]
12)  Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM.
Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.
J. Immunol. 182: 4328-38, 2009.
[Journal]
13)  Kortylewski M, Kujawski M, Herrmann A, Yang C, Wang L, Liu Y, Salcedo R, Yu H.
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy.
Cancer Res. 69: 2497-505, 2009.
[Journal]
14)  Stauffer JK, Khan T, Salcedo R, Hixon JA, Lincoln E, Back TC, Wigginton JM.
Multicolor fluorescence-based approaches for imaging cytokine-induced alterations in the neovascularization, growth, metastasis, and apoptosis of murine neuroblastoma tumors.
J. Immunother. 29: 151-64, 2006.
[Journal]
15)  Khan T, Stauffer JK, Williams R, Hixon JA, Salcedo R, Lincoln E, Back TC, Powell D, Lockett S, Arnold AC, Sayers TJ, Wigginton JM.
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.
J. Immunol. 176: 6302-12, 2006.
[Journal]
16)  Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM.
Formylpeptide receptor FPR and the rapid growth of malignant human gliomas.
J. Natl. Cancer Inst. 97: 823-35, 2005.
[Journal]
17)  Salcedo R, Stauffer JK, Lincoln E, Back TC, Hixon JA, Hahn C, Shafer-Weaver K, Malyguine A, Kastelein R, Wigginton JM.
IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells.
J. Immunol. 173: 7170-82, 2004.
[Journal]
18)  Salcedo R, Zhang X, Young HA, Michael N, Wasserman K, Ma WH, Martins-Green M, Murphy WJ, Oppenheim JJ.
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.
Blood. 102: 1966-77, 2003.
[Journal]
19)  Salcedo R, Oppenheim JJ.
Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses.
Microcirculation. 10: 359-70, 2003.
[Journal]
20)  Chen X, Beutler JA, McCloud TG, Loehfelm A, Yang L, Dong HF, Chertov OY, Salcedo R, Oppenheim JJ, Howard OM.
Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.
Clin. Cancer Res. 9: 3115-23, 2003.
[Journal]
21)  Salcedo R, Martins-Green M, Gertz B, Oppenheim JJ, Murphy WJ.
Combined administration of antibodies to human interleukin 8 and epidermal growth factor receptor results in increased antimetastatic effects on human breast carcinoma xenografts.
Clin. Cancer Res. 8: 2655-65, 2002.
[Journal]
22)  Schneider GP, Salcedo R, Dong HF, Kleinman HK, Oppenheim JJ, Howard OM.
Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha.
Clin. Cancer Res. 8: 3955-60, 2002.
[Journal]
23)  Salcedo R, Young HA, Ponce ML, Ward JM, Kleinman HK, Murphy WJ, Oppenheim JJ.
Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells.
J. Immunol. 166: 7571-8, 2001.
[Journal]
24)  Schneider GP, Salcedo R, Welniak LA, Howard OM, Murphy WJ.
The diverse role of chemokines in tumor progression: prospects for intervention (Review).
Int. J. Mol. Med. 8: 235-44, 2001.
[Journal]
25)  Tani K, Murphy WJ, Chertov O, Salcedo R, Koh CY, Utsunomiya I, Funakoshi S, Asai O, Herrmann SH, Wang JM, Kwak LW, Oppenheim JJ.
Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens.
Int. Immunol. 12: 691-700, 2000.
[Journal]
26)  Salcedo R, Resau JH, Halverson D, Hudson EA, Dambach M, Powell D, Wasserman K, Oppenheim JJ.
Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells.
FASEB J. 14: 2055-64, 2000.
[Journal]
27)  Salcedo R, Ponce ML, Young HA, Wasserman K, Ward JM, Kleinman HK, Oppenheim JJ, Murphy WJ.
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.
Blood. 96: 34-40, 2000.
[Journal]
28)  Salcedo R, Wasserman K, Young HA, Grimm MC, Howard OM, Anver MR, Kleinman HK, Murphy WJ, Oppenheim JJ.
Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.
Am. J. Pathol. 154: 1125-35, 1999.
[Journal]
29)  Salcedo R, Segura C, Szekely L, de Mesquita R, Biberfeld P, Patarroyo M.
Endogenous fibronectin of blood polymorphonuclear leukocytes: immunochemical characterization and subcellular localization.
Exp. Cell Res. 233: 25-32, 1997.
[Journal]
30)  Salcedo R, Wasserman K, Patarroyo M.
Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase.
Exp. Cell Res. 233: 33-40, 1997.
[Journal]
31)  Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R.
The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.
Eur. J. Biochem. 238: 325-32, 1996.
[Journal]
32)  Salcedo R, Patarroyo M.
Constitutive alpha V beta 3 integrin-mediated adhesion of human lymphoid B cells to vitronectin substrate.
Cell. Immunol. 160: 165-72, 1995.
[Journal]
33)  Nortamo P, Salcedo R, Timonen T, Patarroyo M, Gahmberg CG.
A monoclonal antibody to the human leukocyte adhesion molecule intercellular adhesion molecule-2. Cellular distribution and molecular characterization of the antigen.
J. Immunol. 146: 2530-5, 1991.
[Journal]
34)  Seth R, Salcedo R, Patarroyo M, Makgoba MW.
ICAM-2 peptides mediate lymphocyte adhesion by binding to CD11a/CD18 and CD49d/CD29 integrins.
FEBS Lett. 282: 193-6, 1991.
[Journal]
35)  Salcedo R, Fuerstenberg SM, Patarroyo M, Winberg G.
The Epstein-Barr virus BNLF-1 membrane protein LMP1 induces homotypic adhesion mediated by CD11a/CD18 in a murine B-cell line, mimicking the action of phorbol ester.
J. Virol. 65: 5558-63, 1991.
[Journal]
36)  Gahmberg CG, Nortamo P, Kantor C, Autero M, Kotovuori P, Hemiö L, Salcedo R, Patarroyo M.
The pivotal role of the Leu-CAM and ICAM molecules in human leukocyte adhesion.
Cell Differ. Dev. 32: 239-45, 1990.
[Journal]
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This page was last updated on 4/11/2014.