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Yinling Hu, Ph.D.

Selected Publications

1)  Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR.
IKKa Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells.
Cell Rep. 7: 1914-25, 2014.
2)  Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y.
An IKKa-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity.
Cell Rep. 5: 1243-55, 2013.
3)  Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC.
Context-specific BAFF-R signaling by the NF-?B and PI3K pathways.
Cell Rep. 5: 1022-35, 2013.
4)  Xia X, Park E, Fischer SM, Hu Y.
Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis.
Cancers (Basel). 5: 170-83, 2013.
5)  Xiao Z, Jiang Q, Willette-Brown J, Hu Y.
Mouse model resembling human lung cancer.
Oncotarget. 4: 810-1, 2013.
6)  Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song N, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong K, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
The Pivotal Role of IKKalpha in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Cancer Cell. 23: 527-40, 2013.
7)  Liu S, Chen Z, Zhu F, Hu Y.
IkappaB kinase alpha and cancer.
J. Interferon Cytokine Res. 32: 152-8, 2012.
8)  Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y.
IKKalpha-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood. 119: 5467-77, 2012.
9)  Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree RB, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte BC, Hammond NL, Dixon MJ, Sharpe PT.
The role of Irf6 in tooth epithelial invagination.
Dev. Biol. 365: 61-70, 2012.
10)  Liu B, Willette-Brown J, Liu S, Chen X, Fischer SM, Hu Y.
IKKalpha represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin.
Cell Death Differ. 18: 1854-64, 2011.
11)  Park E, Liu B, Xia X, Zhu F, Jami W, Hu Y.
Role of IKKalpha in skin squamous cell carcinomas.
Future Oncol. 7: 123-34, 2011.
12)  Xia X, Park E, Liu B, Willette-Brown J, Gong W, Wang J, Mitchell D, Fischer SM, Hu Y.
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
Am. J. Pathol. 176: 2500-8, 2010.
13)  Liu B, Zhu F, Xia X, Park E, Hu Y.
A tale of terminal differentiation: IKKalpha, the master keratinocyte regulator.
Cell Cycle. 8: 527-31, 2009.
14)  Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y.
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Histol. Histopathol. 24: 265-71, 2009.
15)  Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y.
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
Cancer Cell. 14: 212-25, 2008.
16)  Zhu F, Xia X, Liu B, Shen J, Hu Y, Person M, Hu Y.
IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.
Mol. Cell. 27: 214-27, 2007.
17)  Park E, Zhu F, Liu B, Xia X, Shen J, Bustos T, Fischer SM, Hu Y.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Cancer Res. 67: 9158-68, 2007.
18)  Lomada D, Liu B, Coghlan L, Hu Y, Richie ER.
Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells.
J. Immunol. 178: 829-37, 2007.
19)  Liu B, Park E, Zhu F, Bustos T, Liu J, Shen J, Fischer SM, Hu Y.
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 103: 17202-7, 2006.
20)  Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT.
A dual role for Ikk alpha in tooth development.
Dev. Cell. 6: 219-27, 2004.
21)  Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M.
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Science. 293: 1495-9, 2001.
22)  Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M.
IKKalpha controls formation of the epidermis independently of NF-kappaB.
Nature. 410: 710-4, 2001.
23)  Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M.
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
Science. 284: 316-20, 1999.
24)  Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M.
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
J. Exp. Med. 189: 1839-45, 1999.
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This page was last updated on 7/24/2014.