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Our Science – Casellas Website

Rafael Casellas, Ph.D.

Selected Publications

1)  Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 155: 1507-20, 2013.
2)  Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, Casellas R.
Global regulation of promoter melting in naive lymphocytes.
Cell. 153: 988-99, 2013.
3)  Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, Nussenzweig A, Hager GL, Nussenzweig MC, Casellas R.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature. 484: 69-74, 2012.
4)  Nakahashi H, Kwon KK, Resch W, Vian L, Dose M, Stavreva D, Hakim O, Pruett N, Nelson S, Yamane A, Qian J, Dubois W, Welsh S, Phair RD, Pugh BF, Lobanenkov V, Hager GL, Casellas R.
A genome-wide map of CTCF multivalency redefines the CTCF code.
Cell Rep. 3: 1678-89, 2013.
5)  Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature. 447: 730-4, 2007.
6)  Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun H, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.
A mouse model of HIES reveals pro and anti-inflammatory functions of STAT3.
Blood. [Epub ahead of print], 2014.
7)  Jankovic M, Feldhahn N, Oliveira TY, Silva IT, Kieffer-Kwon K, Yamane A, Resch W, Klein I, Robbiani DF, Casellas R, Nussenzweig MC.
53BP1 Alters the Landscape of DNA Rearrangements and Suppresses AID-Induced B Cell Lymphoma.
Mol. Cell. 49: 623-31, 2013.
8)  Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.
B cell-specific deficiencies in mTOR limit humoral immune responses.
J. Immunol. 191: 1692-703, 2013.
9)  Rommel PC, Bosque D, Gitlin AD, Croft GF, Heintz N, Casellas R, Nussenzweig MC, Kriaucionis S, Robbiani DF.
Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.
PLoS ONE. 8: e69208, 2013.
10)  Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability.
Cell. 152: 620-32, 2013.
11)  Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF.
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
J. Exp. Med. 210: 115-23, 2013.
12)  Rosales T, Nie Z, Kapoor V, Casellas R, Knutson JR, Levens D.
Partition of Myc into immobile vs. mobile complexes within nuclei.
Sci Rep. 3: 1953, 2013.
13)  Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC.
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science. 339: 711-5, 2013.
14)  Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R.
RPA Accumulation during Class Switch Recombination Represents 5"-3" DNA-End Resection during the S-G2/M Phase of the Cell Cycle.
Cell Rep. 3: 138-47, 2013.
15)  Casellas R, Resch W, Hakim O, Nussenzweig MC.
The origin of B cell recurrent chromosomal translocations: proximity versus DNA damage.
Mol. Cell. 51: 275-6, 2013.
16)  Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, Gommerman JL.
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.
Nature. 481: 199-203, 2012.
17)  Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green DR, Tessarollo L, Casellas R, Zhao K, Levens D.
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells.
Cell. 151: 68-79, 2012.
18)  Kovalchuk AL, Ansarah-Sobrinho C, Hakim O, Resch W, Tolarová H, Dubois W, Yamane A, Takizawa M, Klein I, Hager GL, Morse HC, Potter M, Nussenzweig MC, Casellas R.
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation.
Proc. Natl. Acad. Sci. U.S.A. 109: 10972-7, 2012.
19)  Spehalski E, Kovalchuk AL, Collins JT, Liang G, Dubois W, Morse HC, Ferguson DO, Casellas R, Dunnick WA.
Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.
Proc. Natl. Acad. Sci. U.S.A. 109: 13728-32, 2012.
20)  Takahashi H, Kanno T, Nakayamada S, Hirahara K, Sciumè G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, O'Shea JJ.
TGF-beta and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nat Immunol. 13: 587-95, 2012.
21)  Baba M, Keller JR, Sun HW, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon KR, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, Tessarollo L, Schmidt LS, Linehan WM, Casellas R.
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development.
Blood. 120: 1254-61, 2012.
22)  Meredith MM, Liu K, Kamphorst AO, Idoyaga J, Yamane A, Guermonprez P, Rihn S, Yao K, Silva IT, Oliveira TY, Skokos D, Casellas R, Nussenzweig MC.
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.
J. Exp. Med. 209: 1583-93, 2012.
23)  Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride K, Nussenzweig MC, Casellas R.
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.
Nat. Immunol. 12: 62-9, 2011.
24)  Oliveira T, Resch W, Jankovic M, Casellas R, Nussenzweig MC, Klein IA.
Translocation capture sequencing: A method for high throughput mapping of chromosomal rearrangements.
J Immunol Methods. 375: 176-81, 2011.
25)  Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC.
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Cell. 147: 95-106, 2011.
26)  Pavri R, Gazumyan A, Jankovic M, Di Virgilio M, Klein I, Ansarah-Sobrinho C, Resch W, Yamane A, San-Martin BR, Barreto V, Nieland TJ, Root DE, Casellas R, Nussenzweig MC.
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5.
Cell. 143: 122-33, 2010.
27)  Takizawa M, Kim JS, Tessarollo L, McNeil N, Waldschmidt TJ, Casellas R, Ried T, Janz S.
Genetic reporter system for oncogenic Igh-Myc translocations in mice.
Oncogene. 29: 4113-20, 2010.
28)  Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling HJ, Casellas R, Kanagawa O, Miyawaki A, Kurosaki T.
Preferential localization of IgG memory B cells adjacent to contracted germinal centers.
Proc. Natl. Acad. Sci. U.S.A. 107: 12192-7, 2010.
29)  Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Science. 329: 917-23, 2010.
30)  Kuchen S, Resch W, Yamane A, Kuo N, Li Z, Chakraborty T, Wei L, Laurence A, Yasuda T, Peng S, Hu-Li J, Lu K, Dubois W, Kitamura Y, Charles N, Sun HW, Muljo S, Schwartzberg PL, Paul WE, O'Shea J, Rajewsky K, Casellas R.
Regulation of microRNA expression and abundance during lymphopoiesis.
Immunity. 32: 828-39, 2010.
31)  Ji Y, Resch W, Corbett E, Yamane A, Casellas R, Schatz DG.
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.
Cell. 141: 419-31, 2010.
32)  Casellas R, Yamane A, Kovalchuk AL, Potter M.
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.
Immunology. 126: 316-28, 2009.
33)  Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp N, Martinelli G, Lieber MR, Casellas R, Müschen M.
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.
Cancer Cell. 16: 232-45, 2009.
34)  Takizawa M, Tolarova H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R.
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
J. Exp. Med. 205: 1949-57, 2008.
35)  Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN.
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.
Immunity. 28: 621-9, 2008.
36)  Casellas R, Zhang Q, Zheng NY, Mathias MD, Smith K, Wilson PC.
Igkappa allelic inclusion is a consequence of receptor editing.
J. Exp. Med. 204: 153-60, 2007.
37)  Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R.
Regulation of AID expression in the immune response.
J. Exp. Med. 204: 1145-56, 2007.
38)  Furumoto Y, Brooks S, Olivera A, Takagi Y, Miyagishi M, Taira K, Casellas R, Beaven MA, Gilfillan AM, Rivera J.
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival.
J. Immunol. 176: 5167-71, 2006.
39)  Jankovic M, Casellas R, Yannoutsos N, Wardemann H, Nussenzweig MC.
RAGs and regulation of autoantibodies.
Annu. Rev. Immunol. 22: 485-501, 2004.
40)  Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M.
OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.
Cell. 110: 575-85, 2002.
41)  Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature. 414: 660-5, 2001.
42)  Casellas R, Shih TA, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, Nussenzweig MC.
Contribution of receptor editing to the antibody repertoire.
Science. 291: 1541-4, 2001.
43)  Meffre E, Casellas R, Nussenzweig MC.
Antibody regulation of B cell development.
Nat. Immunol. 1: 379-85, 2000.
44)  Yu W, Nagaoka H, Misulovin Z, Meffre E, Suh H, Jankovic M, Yannoutsos N, Casellas R, Besmer E, Papavasiliou F, Qin X, Nussenzweig MC.
RAG expression in B cells in secondary lymphoid tissues.
Cold Spring Harb. Symp. Quant. Biol. 64: 207-10, 1999.
45)  Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC.
Ku80 is required for immunoglobulin isotype switching.
EMBO J. 17: 2404-11, 1998.
46)  Casellas R, Brivanlou AH.
Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer.
Dev. Biol. 198: 1-12, 1998.
47)  Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC.
V(D)J recombination in mature B cells: a mechanism for altering antibody responses.
Science. 278: 298-301, 1997.
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This page was last updated on 6/16/2014.