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Our Science – Casellas Website

Rafael Casellas, Ph.D.

Selected Publications

1)  Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 155: 1507-20, 2013.
2)  Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, Casellas R.
Global regulation of promoter melting in naive lymphocytes.
Cell. 153: 988-99, 2013.
3)  Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, Nussenzweig A, Hager GL, Nussenzweig MC, Casellas R.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature. 484: 69-74, 2012.
4)  Nakahashi H, Kwon KK, Resch W, Vian L, Dose M, Stavreva D, Hakim O, Pruett N, Nelson S, Yamane A, Qian J, Dubois W, Welsh S, Phair RD, Pugh BF, Lobanenkov V, Hager GL, Casellas R.
A genome-wide map of CTCF multivalency redefines the CTCF code.
Cell Rep. 3: 1678-89, 2013.
5)  Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature. 447: 730-4, 2007.
6)  Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun H, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.
A mouse model of HIES reveals pro and anti-inflammatory functions of STAT3.
Blood. [Epub ahead of print], 2014.
7)  Jankovic M, Feldhahn N, Oliveira TY, Silva IT, Kieffer-Kwon K, Yamane A, Resch W, Klein I, Robbiani DF, Casellas R, Nussenzweig MC.
53BP1 Alters the Landscape of DNA Rearrangements and Suppresses AID-Induced B Cell Lymphoma.
Mol. Cell. 49: 623-31, 2013.
8)  Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.
B cell-specific deficiencies in mTOR limit humoral immune responses.
J. Immunol. 191: 1692-703, 2013.
9)  Rommel PC, Bosque D, Gitlin AD, Croft GF, Heintz N, Casellas R, Nussenzweig MC, Kriaucionis S, Robbiani DF.
Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.
PLoS ONE. 8: e69208, 2013.
10)  Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability.
Cell. 152: 620-32, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 6/16/2014.