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Our Science – Wiest Website

Jonathan S. Wiest, Ph.D.

Selected Publications

1)  Nelson DE, Faupel-Badger J, Phillips S, Belcher B, Chang S, Abrams DB, Kramer BS, White MC, O'Malley M, Varanasi AP, Fabian CJ, Wiest JS, Colditz GA, Hall K, Shields PG, Weitzel JN.
Future directions for postdoctoral training in cancer prevention: insights from a panel of experts.
Cancer Epidemiol. Biomarkers Prev. 23: 679-83, 2014.
2)  DeCicco-Skinner KL, Nolan SJ, Deshpande MM, Trovato EL, Dempsey TA, Wiest JS.
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.
PLoS ONE. 8: e56212, 2013.
3)  Mason JL, Lei M, Faupel-Badger JM, Ginsburg EP, Seger YR, Dijoseph L, Schnell JD, Wiest JS.
Outcome evaluation of the national cancer institute career development awards program.
J Cancer Educ. 28: 9-17, 2013.
4)  Decicco-Skinner K, Jung S, Tabib T, Gwilliam J, Alexander H, Goodheart S, Merchant A, Shan M, Garber C, Wiest J.
Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis.
Carcinogenesis. 34: 2789-98, 2013.
5)  Shan Z, Shakoori A, Bodaghi S, Goldsmith P, Jin J, Wiest JS.
TUSC1, a putative tumor suppressor gene, reduces tumor cell growth in vitro and tumor growth in vivo.
PLoS ONE. 8: e66114, 2013.
6)  Faupel-Badger JM, van Bemmel DM, Wiest JS, Nelson DE.
Expanding cancer prevention education to national and international audiences: the National Cancer Institute's Principles and Practice of Cancer Prevention and Control annual summer course.
J Cancer Educ. 26: 619-25, 2011.
7)  Decicco-Skinner KL, Trovato EL, Simmons JK, Lepage PK, Wiest JS.
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis.
Oncogene. 30: 389-97, 2011.
8)  Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW.
A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers.
Cancer Res. 70: 2359-67, 2010.
9)  You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW.
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
Clin. Cancer Res. 15: 2666-74, 2009.
10)  Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M.
Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.
Cancer Res. 69: 7844-50, 2009.
11)  Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M.
Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
J. Natl. Cancer Inst. 100: 1326-30, 2008.
12)  Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M.
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.
Cancer Res. 67: 4665-70, 2007.
13)  Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Minna J, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson MW, You M.
Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
Cancer Res. 67: 93-9, 2007.
14)  Dennis PA, Van Waes C, Gutkind JS, Kellar KJ, Vinson C, Mukhin AG, Spitz MR, Bailey-Wilson JE, Yeh GC, Anderson LM, Wiest JS.
The biology of tobacco and nicotine: bench to bedside.
Cancer Epidemiol. Biomarkers Prev. 14: 764-7, 2005.
15)  Seminara D, Minna J, Anderson MW, Zhang Q, Liu Q, Zeng D, Zhou X, Perez A, Kupert E, Gaba C, Lee J, Slusser J, Coons T, Mandal D, Rothschild H, Gazdar A, Klein C, Franklin W, You M, Schwartz AG, Fain P, Wiest JS, de Andrade M, Petersen GM, Pinney SM, Amos CI, Bailey-Wilson JE.
A major lung cancer susceptibility locus maps to chromosome 6q23-25.
Am J Hum Genet. 75: 460-74, 2004.
16)  Shan Z, Parker T, Wiest JS.
Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer.
Oncogene. 23: 6612-20, 2004.
17)  Clark AM, Reynolds SH, Anderson M, Wiest JS.
Mutational activation of the MAP3K8 protooncogene in lung cancer.
Genes Chromosomes Cancer. 41: 99-108, 2004.
18)  Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M.
LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.
Oncogene. 22: 1243-6, 2003.
19)  Leikauf GD, McDowell SA, Bachurski CJ, Aronow BJ, Gammon K, Wesselkamper SC, Hardie W, Wiest JS, Leikauf JE, Korfhagen TR, Prows DR.
Functional genomics of oxidant-induced lung injury.
Adv Exp Med Biol. 500: 479-87, 2001.
20)  Wiest J, Clark AM, Dai W.
Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines.
Genes, Chromosomes, Cancer. 32: 384-389, 2001.
21)  Leikauf GD, McDowell SA, Wesselkamper SC, Miller CR, Hardie WD, Gammon K, Biswas PP, Korfhagen TR, Bachurski CJ, Wiest JS, Willeke K, Bingham E, Leikauf JE, Aronow BJ, Prows DR.
Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice.
Res Rep Health Eff Inst. 5-58; discussion 59-71, 2001.
22)  Shepherd T, Tolbert D, Benedetti J, Macdonald J, Stemmermann G, Wiest J, DeVoe G, Miller MA, Wang J, Noffsinger A, Fenoglio-Preiser C.
Alterations in Exon 4 of the p53 Gene in Gastric Cancer.
Gastroenterology. 118: 1039-1044, 2000.
23)  McDowell SA, Gammon K, Bachurski CJ, Wiest JS, Leikauf JE, Prows DR, Leikauf GD.
Differential gene expression in the initiation and progression of nickel-induced acute lung injury.
Am. J. Respir. Cell. Mol. Biol. 23: 466-474, 2000.
24)  Werness BA, Parvatiyar P, Ramus SJ, Whittemore AS, Garlinghouse-Jones K, Oakley-Girvan I, DiCioccio RA, Wiest J, Tsukada Y, Ponder BA, Piver MS.
Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.
J Natl Cancer Inst. 92: 1088-1091, 2000.
25)  Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P.
Prk, A Cell Cycle Protein Kinase Gene Mapped to 8p21, Is Down Regulated In Head/Neck Squamous Cell Carcinomas.
Genes, Chromosomes and Cancer. 27: 332-336, 2000.
26)  Deka R, Guangyun S, Wiest J, Smelser D, Chunhua S, Zhong Y, Chakraborty R.
Patterns of Instability of Expanded CAG Repeats at the ERDA1 Locus in General Populations.
Am. J. Hum. Gen. 65: 192-198, 1999.
27)  Chadwick BP, Campbell LJ, Jackson CL, Ozelius L, Slaugenhaupt SA, Stephenson DA, Edwards JH, Wiest J, Povey S.
Report on the Sixth International Workshop on Chromosome 9 held at Denver, Colorado, USA, October 27, 1998.
Ann Hum Genet. 63: 101-117, 1999.
28)  Jones-Bolin SE, Johansson E, Palmisano WA, Anderson MW, Wiest JS, Belinsky SA.
Effect of Promoter and Intron 2 Polymorphisms on Murine Lung K-ras Gene Expression.
Carcinogenesis. 19: 1503-1508, 1998.
29)  Wiest JS, Franklin WA, Drabkin H, Gemmill R, Sidransky D, Anderson MW.
Genetic Markers for Early Detection of Lung Cancer and Outcome Measures for Response to Chemoprevention.
J. Cellular Biochemistry Suppl. 28-29: 64-73, 1997.
30)  Todd S, Franklin WA, Varella-Garcia M, Kennedy T, Hilliker CE, Hahner L, Anderson M, Wiest JS, Drabkin HA, Gemmill RM.
Homozygous Deletions of Human Chromosome 3p in Lung Tumors.
Cancer Research. 57: 1344-1352, 1997.
31)  Wiest JS, Franklin WA, Otstot JT, Forbey K, Varella-Garcia M, Rao K, Drabkin H, Gemmill R, Ahrent S, Sidransky D, Saccomanno G, Fountain JW, Anderson MW.
Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor gene.
Cancer Res. 57: 1-6, 1997.
32)  Michels R, Davidson L, Timm SS, Rieniets E, Conwell K, Saccomanno G, Wiest J, Anderson M.
Saccomanno Smear Slides and Megafunnel Slides for Sputum Specimens: A Comparison.
Acta Cytologica. 41: 1774-1780, 1997.
33)  Anderson M, Sladon S, Michels R, Davidson L, Conwell K, Lechner J, Franklin W, Saccomanno G, Wiest J.
Examination of p53 Alterations and Cytokeratin Expression in Sputa Collected from Patients Prior to Histological Diagnosis of Squamous Cell Carcinoma.
J. Cellular Biology. 64: 185-190, 1996.
34)  Wiest JS, Burnett VL, Anderson MW, Reynolds SH.
A Novel Mechanism of In Vivo ras Gene Activation Involving Tandem Duplication of Coding Sequences.
Oncogene. 9: 2449-2454, 1994.
35)  Chen B, Johanson L, Wiest JS, Anderson MW, You M.
The Second Exon of the K-ras Gene Contains Regulatory Elements Associated with Mouse Lung Tumor Susceptibility.
Proc. Natl Acad. Sci. 91: 1589-1593, 1994.
36)  Bell DA, Taylor JA, Butler MA, Stephens EA, Wiest J, Brubaker LH, Kadlubar FF, Lucier GW.
Genotype/phenotype Discordance for Human Arylamine N-Actelytransferase (NAT2) Reveals a New Slow-Acetylator Allele Common in African-Americans.
Carcinogenesis. 14: 1689-1692, 1993.
37)  Reynolds SH, Wiest JS, Devereux TR, Anderson MW, You M.
Protooncogene activation in spontaneously occurring and chemically induced rodent and human lung tumors.
Prog Clin Biol Res. 376: 303-20, 1992.
38)  Reynolds SH, Anna CK, Brown KC, Wiest JS, Beattie EJ, Pero RW, Iglehart JD, Anderson MW.
Activated Protooncogenes in Human Lung from Smokers.
Proc. Natl. Acad. Sci. 88: 1085-1089, 1991.
39)  Wiest JS, McCorquodale DJ.
Characterization of Pre-Early Genes in the Terminal Repetition of Bacteriophage BF23 DNA by Nucleotide Sequencing and Restriction Mapping.
Virology. 177: 745-752, 1990.
40)  Appert HE, Rutherford TJ, Tarr GE, Wiest JS, Thomford NR, McCorquodale DJ.
Isolation of a cDNA Coding for Human Galactosyl Transferase.
BBRC. 193: 63-168, 1986.
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This page was last updated on 5/20/2014.