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Our Science – Li Website

Luowei Li, Ph.D.

Selected Publications

1)  Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A, Bíró T, Yuspa SH, Blumberg PM.
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.
Cancer Res. 70: 7905-17, 2010.
[Journal]
2)  Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH.
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Cancer Res. 70: 4509-19, 2010.
[Journal]
3)  Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009.
[Journal]
4)  Suh KS, Mutoh M, Mutoh T, Li L, Ryscavage A, Crutchley JM, Dumont RA, Cheng C, Yuspa SH.
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation.
J. Cell. Sci. 120: 2631-40, 2007.
[Journal]
5)  Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH.
Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1.
J. Cell. Sci. 120: 2851-63, 2007.
[Journal]
6)  Li L, Sampat K, Hu N, Zakari J, Yuspa SH.
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes.
J. Biol. Chem. 281: 3237-43, 2006.
[Journal]
7)  Seong YS, Min C, Li L, Yang JY, Kim SY, Cao X, Kim K, Yuspa SH, Chung HH, Lee KS.
Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026.
Cancer Res. 63: 7384-91, 2003.
[Journal]
8)  Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG.
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
J. Biol. Chem. 278: 33753-62, 2003.
[Journal]
9)  Alt A, Ohba M, Li L, Gartsbein M, Belanger A, Denning MF, Kuroki T, Yuspa SH, Tennenbaum T.
Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment.
Cancer Res. 61: 4591-8, 2001.
[Journal]
10)  Acs P, Beheshti M, Szállási Z, Li L, Yuspa SH, Blumberg PM.
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.
Carcinogenesis. 21: 887-91, 2000.
[Journal]
11)  Yuspa SH, Hansen L, Li L, Joseloff E, Weinberg W, Fernandez-Salas E.
Interacting signaling pathways in the pathogenesis of squamous cell carcinoma.
Medicina (B Aires). 60: 689-92, 2000.
[Journal]
12)  Fujii T, García-Bermejo ML, Bernabó JL, Caamaño J, Ohba M, Kuroki T, Li L, Yuspa SH, Kazanietz MG.
Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta.
J. Biol. Chem. 275: 7574-82, 2000.
[Journal]
13)  Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH.
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector.
Mol. Cell. Biol. 19: 8547-58, 1999.
[Journal]
14)  Li W, Chen XH, Kelley CA, Alimandi M, Zhang J, Chen Q, Bottaro DP, Pierce JH.
Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site.
J. Biol. Chem. 271: 26404-9, 1996.
[Journal]
15)  Tennenbaum T, Li L, Belanger AJ, De Luca LM, Yuspa SH.
Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation.
Cell Growth Differ. 7: 615-28, 1996.
[Journal]
16)  Li L, Tennenbaum T, Yuspa SH.
Suspension-induced murine keratinocyte differentiation is mediated by calcium.
J. Invest. Dermatol. 106: 254-60, 1996.
[Journal]
17)  Li L, Tucker RW, Hennings H, Yuspa SH.
Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro.
J. Cell. Physiol. 163: 105-14, 1995.
[Journal]
18)  Li L, Tucker RW, Hennings H, Yuspa SH.
Inhibitors of the intracellular Ca(2+)-ATPase in cultured mouse keratinocytes reveal components of terminal differentiation that are regulated by distinct intracellular Ca2+ compartments.
Cell Growth Differ. 6: 1171-84, 1995.
[Journal]
19)  Punnonen K, Denning M, Lee E, Li L, Rhee SG, Yuspa SH.
Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes.
J. Invest. Dermatol. 101: 719-26, 1993.
[Journal]
20)  Li L, Kruszewski FH, Punnonen K, Tucker RW, Yuspa SH, Hennings H.
Strontium induces murine keratinocyte differentiation in vitro in the presence of serum and calcium.
J. Cell. Physiol. 154: 643-53, 1993.
[Journal]
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This page was last updated on 10/25/2010.