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Our Science – Kedei Website

Noemi Kedei, M.D.

Selected Publications
1)  Pu Y, Garfield SH, Kedei N, Blumberg PM.
Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta.
J. Biol. Chem. 284: 1302-12, 2009. [Journal]
2)  Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
J. Med. Chem. 52: 3274-83, 2009. [Journal]
3)  Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM.
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
Org. Lett. 11: 593-6, 2009. [Journal]
4)  Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM.
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
Org. Lett. 11: 2277-80, 2009. [Journal]
5)  Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM.
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.
J. Biol. Chem. 283: 10543-9, 2008. [Journal]
6)  Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
J. Med. Chem. 51: 5198-220, 2008. [Journal]
7)  Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM.
Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function.
J. Am. Chem. Soc. 2008. [Journal]
8)  Philosof-Mazor L, Volinsky R, Comin MJ, Lewin NE, Kedei N, Blumberg PM, Marquez VE, Jelinek R.
Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.
Langmuir : the ACS journal of surfaces and colloids. 24: 11043-52, 2008. [Journal]
9)  Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, Pu Y, Peach ML, Marquez VE.
Wealth of opportunity - the C1 domain as a target for drug development.
Current drug targets. 9: 641-52, 2008. [Journal]
10)  Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE.
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
J. Med. Chem. 50: 962-78, 2007. [Journal]
11)  Lizanecz E, Bagi Z, Pásztor ET, Papp Z, Edes I, Kedei N, Blumberg PM, Tóth A.
Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1.
Mol. Pharmacol. 69: 1015-23, 2006. [Journal]
12)  Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE.
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
J. Biol. Chem. 280: 27329-38, 2005. [Journal]
13)  Tóth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM.
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.
Life Sci. 76: 2921-32, 2005. [Journal]
14)  Tóth A, Boczán J, Kedei N, Lizanecz E, Bagi Z, Papp Z, Edes I, Csiba L, Blumberg PM.
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain.
Brain Res. Mol. Brain Res. 135: 162-8, 2005. [Journal]
15)  Qiang YW, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS, Shaughnessy J, Rudikoff S.
Wnts induce migration and invasion of myeloma plasma cells.
Blood. 106: 1786-93, 2005. [Journal]
16)  Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM.
Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Cancer Res. 64: 3243-55, 2004. [Journal]
17)  Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM.
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Org. Biomol. Chem. 2: 2281-6, 2004. [Journal]
18)  Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM.
Interaction between protein kinase Cmu and the vanilloid receptor type 1.
J. Biol. Chem. 279: 53674-82, 2004. [Journal]
19)  Tóth A, Kedei N, Wang Y, Blumberg PM.
Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.
Life Sci. 73: 487-98, 2003. [Journal]
20)  Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM.
Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.
Biochem. Biophys. Res. Commun. 293: 777-82, 2002. [Journal]
21)  Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM.
Analysis of the native quaternary structure of vanilloid receptor 1.
J. Biol. Chem. 276: 28613-9, 2001. [Journal]
22)  Szondy Z, Molnar P, Nemes Z, Boyiadzis M, Kedei N, Tóth R, Fésüs L.
Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways.
FEBS Lett. 404: 307-13, 1997. [Journal]
23)  Balajthy Z, Kedei N, Nagy L, Davies PJ, Fésüs L.
Lack of induction of tissue transglutaminase but activation of the preexisting enzyme in c-Myc-induced apoptosis of CHO cells.
Biochem. Biophys. Res. Commun. 236: 280-4, 1997. [Journal]
24)  Schittny JC, Paulsson M, Vallan C, Burri PH, Kedei N, Aeschlimann D.
Protein cross-linking mediated by tissue transglutaminase correlates with the maturation of extracellular matrices during lung development.
Am. J. Respir. Cell Mol. Biol. 17: 334-43, 1997. [Journal]
25)  Taresa E, Kedei N, Thomazy V, Fesus L.
An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis.
J. Biol. Chem. 267: 25648-51, 1992. [Journal]
26)  Fesus L, Tarcsa E, Kedei N, Autuori F, Piacentini M.
Degradation of cells dying by apoptosis leads to accumulation of epsilon(gamma-glutamyl)lysine isodipeptide in culture fluid and blood.
FEBS Lett. 284: 109-12, 1991. [Journal]
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This page was last updated on 9/24/2009.