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Our Science – Kedei Website

Noemi Kedei, M.D.

Selected Publications

1)  Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
A phospholipase C-?1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.
J. Immunol. 190: 147-58, 2013.
[Journal]
2)  Chen JQ, Heldman MR, Herrmann MA, Kedei N, Woo W, Blumberg PM, Goldsmith PK.
Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.
Anal. Biochem. 442: 97-103, 2013.
[Journal]
3)  Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE.
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
ACS Chem. Biol. 8: 767-77, 2013.
[Journal]
4)  Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM.
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Biochem. Pharmacol. 85: 313-24, 2013.
[Journal]
5)  Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J.
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase C? (PKC?).
Biochem. J. 451: 33-44, 2013.
[Journal]
6)  Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC.
RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.
PLoS ONE. 8: e72331, 2013.
[Journal]
7)  Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM.
Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.
J. Biol. Chem. 287: 13137-58, 2012.
[Journal]
8)  Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM.
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Bioorg. Med. Chem. Lett. 22: 4084-8, 2012.
[Journal]
9)  Gal N, Kolusheva S, Kedei N, Telek A, Naeem TA, Lewin NE, Lim L, Mannan P, Garfield SH, El Kazzouli S, Sigano DM, Marquez VE, Blumberg PM, Jelinek R.
N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity.
Chembiochem. 12: 2331-40, 2011.
[Journal]
10)  Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
Oncogene. 30: 4590-600, 2011.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/9/2014.