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Our Science – Poirier Website

Miriam C. Poirier, Ph.D.

Selected Publications

1)  Olivero OA, Shearer GM, Chougnet CA, Kovacs AA, Landay AL, Baker R, Stek AM, Khoury MM, Proia LA, Kessler HA, Sha BE, Tarone RE, Poirier MC.
Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero.
AIDS. 13: 919-25, 1999.
2)  Divi RL, Walker VE, Wade NA, Nagashima K, Seilkop SK, Adams ME, Nesel CJ, O'Neill JP, Abrams EJ, Poirier MC.
Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir.
AIDS. 18: 1013-21, 2004.
3)  Divi RL, Leonard SL, Kuo MM, Nagashima K, Thamire C, St Claire MC, Wade NA, Walker VE, Poirier MC.
Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.
Environ. Mol. Mutagen. 48: 201-9, 2006.
4)  Pratt MM, John K, MacLean AB, Afework S, Phillips DH, Poirier MC.
Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues.
Int J Environ Res Public Health. 8: 2675-91, 2011.
5)  Olivero OA, Rivera Torres L, Gorjifard S, Momot D, Marrogi E, Divi RL, Liu Y, Woodward RA, Sowers MJ, Poirier MC.
Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.
J. Infect. Dis. 208: 244-248, 2013.
6)  Poirier MC, Schwartz JL, Aardema MJ.
Achieving professional success in US Government, academia, and industry: An EMGS commentary.
Environ. Mol. Mutagen. [Epub ahead of print], 2014.
7)  Onwuamah CK, Ekama SO, Audu RA, Ezechi OC, Poirier MC, Odeigah PG.
Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes.
PLoS ONE. 9: e90296, 2014.
8)  Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC.
Tamoxifen-DNA adduct formation in monkey and human reproductive organs.
Carcinogenesis. 35: 1172-6, 2014.
9)  Liu Y, Shim E, Nguyen P, Gibbons AT, Mitchell JB, Poirier MC.
Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.
Toxicol. Sci. 139: 133-41, 2014.
10)  Herman EH, Knapton A, Liu Y, Lipshultz SE, Estis J, Todd J, Woodward RA, Cochran T, Zhang J, Poirier MC.
The Influence of Age on Serum Concentrations of Cardiac Troponin I: Results in Rats, Monkeys, and Commercial Sera.
Toxicol Pathol. [Epub ahead of print], 2013.
11)  Poirier MC, Weisburger EK.
Chemical Carcinogenesis. In: Cancer the Outlaw Cell.
Oxford, UK: American Chemical Society, Oxford University Press; 2012. p. 179-188 [Book Chapter]
12)  Suastegui WA, Huerta-Chagoya A, Pratt MM, John K, Poirier MC, Petrosyan P, Rubio J, Gonsebatt ME.
PAH-DNA adducts in non-smoking inhabitants of Mexico City. In: Polycyclic Aromatic Hydrocarbons: Chemistry, Occurrence and Health Issues.
Hauppauge, NY: Nova Science Publishers; 2012. p. 100-110 [Book Chapter]
13)  John K, Pratt MM, Beland FA, Churchwell MI, McMullen G, Olivero OA, Pogribny I, Poirier MC.
Benzo[a]pyrene (BP) DNA adduct formation in DNA repair deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild type mice fed BP and BP plus chlorophyllin for 28 days.
Carcinogenesis. 33: 2236-41, 2012.
14)  Poirier MC.
Chemical-induced DNA damage and human cancer risk.
Discov Med. 14: 283-8, 2012.
15)  Georgiadis P, Kovács K, Kaila S, Makedonopoulou P, Anna L, Poirier MC, Knudsen LE, Schoket B, Kyrtopoulos SA.
Development and validation of a direct sandwich chemiluminescence immunoassay for measuring DNA adducts of benzo[a]pyrene and other polycyclic aromatic hydrocarbons.
Mutagenesis. 27: 589-97, 2012.
16)  Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Roland Wolf C, Henderson CJ, Phillips DH.
Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and (32)P-postlabelling.
Toxicol Lett. 213: 160-6, 2012.
17)  Liu Y, Nguyen P, Baris TZ, Poirier MC.
Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs).
Cardiovasc. Toxicol. 12: 123-34, 2012.
18)  Torres S, Walker D, Divi R, Poirier M, Walker V.
Comprehensive Toxicology, 2nd Edition. Volume 6, Cardiovascular Toxicology.
London: Elsevier, LTD; 2011. [Book]
19)  Pratt MM, King LC, Adams LD, John K, Sirajuddin P, Olivero OA, Manchester DK, Sram RJ, DeMarini DM, Poirier MC.
Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic.
Environ. Mol. Mutagen. 52: 58-68, 2011.
20)  García-Suástegui WA, Huerta-Chagoya A, Carrasco-Colín KL, Pratt MM, John K, Petrosyan P, Rubio J, Poirier MC, Gonsebatt ME.
Seasonal variations in the levels of PAH-DNA adducts in young adults living in Mexico City.
Mutagenesis. 26: 385-91, 2011.
21)  Einem Lindeman T, Poirier MC, Divi RL.
The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene.
Mutagenesis. 26: 629-35, 2011.
22)  John K, Divi RL, Keshava C, Orozco CC, Schockley ME, Richardson DL, Poirier MC, Nath J, Weston A.
CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.
Cancer Lett. 292: 254-60, 2010.
23)  Obolenskaya MY, Teplyuk NM, Divi RL, Poirier MC, Filimonova NB, Zadrozna M, Pasanen MJ.
Human placental glutathione S-transferase activity and polycyclic aromatic hydrocarbon DNA adducts as biomarkers for environmental oxidative stress in placentas from pregnant women living in radioactivity- and chemically-polluted regions.
Toxicol. Lett. 196: 80-6, 2010.
24)  Torres SM, March TH, Carter MM, McCash CL, Seilkop SK, Poirier MC, Walker DM, Walker VE.
In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue.
Cardiovasc. Toxicol. 10: 37-50, 2010.
25)  Torres SM, Divi RL, Walker DM, McCash CL, Carter MM, Campen MJ, Einem TL, Chu Y, Seilkop SK, Kang H, Poirier MC, Walker VE.
In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.
Cardiovasc. Toxicol. 10: 87-99, 2010.
26)  Olivero OA, Vazquez IL, Cooch CC, Ming J, Keller E, Yu M, Borojerdi JP, Braun HM, McKee E, Poirier MC.
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.
Toxicol. Sci. 115: 109-17, 2010.
27)  Dutra A, Pak E, Wincovitch S, John K, Poirier MC, Olivero OA.
Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity.
Cytogenet. Genome Res. 128: 105-10, 2010.
28)  Divi RL, Einem TL, Fletcher SL, Shockley ME, Kuo MM, St Claire MC, Cook A, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.
Progressive mitochondrial compromise in brains and livers of primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs).
Toxicol. Sci. 118: 191-201, 2010.
29)  Poirier MC, Olivero OA, Hardy AW, Franchini G, Borojerdi JP, Walker VE, Walker DM, Shearer GM.
Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.
AIDS Res Ther. 6: 24, 2009.
30)  Borojerdi JP, Ming J, Cooch C, Ward Y, Semino-Mora C, Yu M, Braun HM, Taylor BJ, Poirier MC, Olivero OA.
Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.
Mutat. Res. 665: 67-74, 2009.
31)  Yu M, Ward Y, Poirier MC, Olivero OA.
Centrosome amplification induced by the antiretroviral nucleoside reverse transcriptase inhibitors lamivudine, stavudine, and didanosine.
Environ. Mol. Mutagen. 50: 718-24, 2009.
32)  Keshava C, Divi RL, Einem TL, Richardson DL, Leonard SL, Keshava N, Poirier MC, Weston A.
Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells.
Environ. Mol. Mutagen. 50: 134-44, 2009.
33)  John K, Ragavan N, Pratt MM, Singh PB, Al-Buheissi S, Matanhelia SS, Phillips DH, Poirier MC, Martin FL.
Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate.
Prostate. 69: 505-19, 2009.
34)  Schild-Hay LJ, Leil TA, Divi RL, Olivero OA, Weston A, Poirier MC.
Tamoxifen induces expression of immune response-related genes in cultured normal human mammary epithelial cells.
Cancer Res. 69: 1150-5, 2009.
35)  Walker DM, Kajon AE, Torres SM, Carter MM, McCash CL, Swenberg JA, Upton PB, Hardy AW, Olivero OA, Shearer GM, Poirier MC, Walker VE.
WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.
Environ. Mol. Mutagen. 50: 460-72, 2009.
36)  Olivero OA, Ming JM, Das S, Vazquez IL, Richardson DL, Weston A, Poirier MC.
Human inter-individual variability in metabolism and genotoxic response to zidovudine.
Toxicol. Appl. Pharmacol. 228: 158-64, 2008.
37)  Divi RL, Doerge DR, Twaddle NC, Shockley ME, St Claire MC, Harbaugh JW, Harbaugh SW, Poirier MC.
Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis.
Toxicol. Appl. Pharmacol. 226: 206-11, 2008.
38)  Courter LA, Luch A, Musafia-Jeknic T, Arlt VM, Fischer K, Bildfell R, Pereira C, Phillips DH, Poirier MC, Baird WM.
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.
Cancer Lett. 265: 135-47, 2008.
39)  van Gijssel HE, Leil TA, Weinberg WC, Divi RL, Olivero OA, Poirier MC.
Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin.
Mutagenesis. 22: 49-54, 2007.
40)  Divi RL, Leonard SL, Walker BL, Kuo MM, Shockley ME, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.
Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age.
Toxicol. Sci. 99: 203-13, 2007.
41)  Gunter MJ, Divi RL, Kulldorff M, Vermeulen R, Haverkos KJ, Kuo MM, Strickland P, Poirier MC, Rothman N, Sinha R.
Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma.
Carcinogenesis. 28: 1426-9, 2007.
42)  Torres SM, Walker DM, Carter MM, Cook DL, McCash CL, Cordova EM, Olivero OA, Poirier MC, Walker VE.
Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations.
Environ. Mol. Mutagen. 48: 224-38, 2007.
43)  Pratt MM, Sirajuddin P, Poirier MC, Schiffman M, Glass AG, Scott DR, Rush BB, Olivero OA, Castle PE.
Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study.
Mutat. Res. 624: 114-23, 2007.
44)  Walker VE, Poirier MC.
Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitors.
Environ Mol Mutagen. 48: 159-65, 2007.
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This page was last updated on 5/15/2014.