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Our Science – Blumberg Website

Peter M. Blumberg, Ph.D.

Selected Publications

1)  Kedei N, Chen J, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM.
Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cd Provides an Integrated Measure of Its Modulation in Response to Ligands.
J. Med. Chem. [Epub ahead of print], 2014.
2)  Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM.
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Biochem. Pharmacol. 85: 313-24, 2013.
3)  Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang J, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM.
Molecular basis for failure of the "atypical" C1 domain of Vav1 to bind diacylglycerol / phorbol ester.
J. Biol. Chem. 287: 13137-58, 2012.
4)  Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
Oncogene. 30(45): 4590-4600, 2011.
5)  Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM.
Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.
J. Am. Chem. Soc. 130: 6660-1, 2008.
6)  Kim HS, Jin MK, Kang SU, Lim JO, Tran PT, Hoang VH, Ann J, Ha TH, Pearce LV, Pavlyukovets VA, Blumberg PM, Lee J.
a-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists.
Bioorg. Med. Chem. Lett. 24: 2685-8, 2014.
7)  Kim MS, Ki Y, Ahn SY, Yoon S, Kim SE, Park HG, Sun W, Son K, Cui M, Choi S, Pearce LV, Esch TE, Deandrea-Lazarus IA, Blumberg PM, Lee J.
Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands.
Bioorg. Med. Chem. Lett. 24: 382-5, 2014.
8)  Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM.
Charge density influences c1 domain ligand affinity and membrane interactions.
Chembiochem. 15: 1131-44, 2014.
9)  Pu Y, Kang J, Sigano DM, Peach ML, Lewin NE, Marquez VE, Blumberg PM.
Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ? and ? from Typical C1 Domains.
J. Med. Chem. [Epub ahead of print], 2014.
10)  Nagy Z, Kovács I, Török M, Tóth D, Vereb G, Buzás K, Juhász I, Blumberg PM, Bíró T, Czifra G.
Function of RasGRP3 in the formation and progression of human breast cancer.
Mol. Cancer. 13: 96, 2014.
Click Here to View Expanded Bibliography.

This page was last updated on 6/16/2014.