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Our Science – Yuspa Website

Stuart H. Yuspa, M.D.

Selected Publications

1)  Mascia F, Lam G, Keith C, Garber C, Steinberg S, Kohn E, Yuspa S.
Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.
Sci.Transl. Med. 5: 199ra110, 2013.
[Journal]
2)  Shukla A, Edwards R, Yang Y, Hahn A, Folkers K, Ding J, Padmakumar VC, Cataisson C, Suh KS, Yuspa SH.
CLIC4 regulates TGF-ß-dependent myofibroblast differentiation to produce a cancer stroma.
Oncogene. [Epub ahead of print], 2013.
[Journal]
3)  Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.
J. Exp. Med. 209: 1689-702, 2012.
[Journal]
4)  Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH.
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.
Carcinogenesis. 33: 986-95, 2012.
[Journal]
5)  Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH.
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.
Proc. Natl. Acad. Sci. U.S.A. 109: 6130-5, 2012.
[Journal]
6)  Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G.
MyD88 and its divergent toll in carcinogenesis.
Trends Immunol. 2013.
[Journal]
7)  Hattinger E, Zwicker S, Ruzicka T, Yuspa SH, Wolf R.
Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis.
Curr Opin Pharmacol. 2013.
[Journal]
8)  Ansbro MR, Shukla S, Ambudkar SV, Yuspa SH, Li L.
Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference.
PLoS ONE. 8: e60334, 2013.
[Journal]
9)  Sengupta A, Lichti UF, Carlson BA, Cataisson C, Ryscavage AO, Mikulec C, Conrad M, Fischer SM, Hatfield DL, Yuspa SH.
Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2.
J. Invest. Dermatol. [Epub ahead of print], 2013.
[Journal]
10)  Patel GK, Yee CL, Yuspa SH, Vogel JC.
A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice.
J. Invest. Dermatol. 132: 284-90, 2012.
[Journal]
11)  Okano J, Levy C, Lichti U, Sun HW, Yuspa SH, Sakai Y, Morasso MI.
Cutaneous retinoic acid levels determine hair follicle development and downgrowth.
J. Biol. Chem. 287: 39304-15, 2012.
[Journal]
12)  Lao HC, Akunda JK, Chun KS, Flake GP, Yuspa SH, Langenbach R.
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
Carcinogenesis. 33: 2293-300, 2012.
[Journal]
13)  Patel GK, Yee CL, Terunuma A, Telford WG, Voong N, Yuspa SH, Vogel JC.
Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma.
J. Invest. Dermatol. 132: 401-9, 2012.
[Journal]
14)  Okano J, Lichti U, Mamiya S, Aronova M, Zhang G, Yuspa SH, Hamada H, Sakai Y, Morasso MI.
Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development.
J. Cell. Sci. 125: 1827-36, 2012.
[Journal]
15)  Wright LN, Ryscavage A, Merlino G, Yuspa SH.
Modeling the transcriptional consequences of epidermal growth factor receptor ablation in Ras-initiated squamous cancer.
Clin. Cancer Res. 18: 170-83, 2012.
[Journal]
16)  Yuspa SH, Kraemer KH, Dlugosz AA, Roop DR, Kulesz-Martin M, Bickenbach JR.
Montagna Symposium 2011: 60th Anniversary--Advances in Science and Medicine Catalyzed by Pioneering Skin Research.
J. Invest. Dermatol. 132: 1317-20, 2012.
[Journal]
17)  Nasser MW, Qamri Z, Deol YS, Ravi J, Powell CA, Trikha P, Schwendener RA, Bai XF, Shilo K, Zou X, Leone G, Wolf R, Yuspa SH, Ganju RK.
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
Cancer Res. 72: 604-15, 2012.
[Journal]
18)  Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk K, Ryscavage A, Dengler S, Hwang S, Edwards J, Coppola V, Tessarollo L, Stepp MA, Yuspa SH.
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.
Am. J. Pathol. 181: 74-84, 2012.
[Journal]
19)  Mascia F, Denning M, Kopan R, Yuspa SH.
The black box illuminated: signals and signaling.
J. Invest. Dermatol. 132: 811-9, 2012.
[Journal]
20)  Yang D, Tao J, Li L, Kedei N, Toth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM.
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
Oncogene. 30: 4590-600, 2011.
[Journal]
21)  Shukla A, Yuspa SH.
CLIC4 and Schnurri-2: A dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease.
Nucleus. 1: 144-149, 2010.
[Journal]
22)  Mascia F, Cataisson C, Lee TC, Threadgill D, Mariani V, Amerio P, Chandrasekhara C, Souto Adeva G, Girolomoni G, Yuspa SH, Pastore S.
EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo.
J. Invest. Dermatol. 130: 682-93, 2010.
[Journal]
23)  Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH.
Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Sci Transl Med. 2: 61ra90, 2010.
[Journal]
24)  Stepp MA, Pal-Ghosh S, Tadvalkar G, Rajjoub L, Jurjus RA, Gerdes M, Ryscavage A, Cataisson C, Shukla A, Yuspa SH.
Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis.
Mol. Carcinog. 49: 363-73, 2010.
[Journal]
25)  Wolf R, Ruzicka T, Yuspa SH.
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Amino Acids. 41: 789-96, 2010.
[Journal]
26)  Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A, Bíró T, Yuspa SH, Blumberg PM.
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.
Cancer Res. 70: 7905-17, 2010.
[Journal]
27)  Malik M, Shukla A, Amin P, Niedelman W, Lee J, Jividen K, Phang JM, Ding J, Suh KS, Curmi PM, Yuspa SH.
S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein, CLIC4.
J. Biol. Chem. 285: 23818-28, 2010.
[Journal]
28)  Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL.
Selenoproteins are essential for proper keratinocyte function and skin development.
PLoS ONE. 5: e12249, 2010.
[Journal]
29)  Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH.
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Cancer Res. 70: 4509-19, 2010.
[Journal]
30)  Pérez-Lorenzo R, Markell LM, Hogan KA, Yuspa SH, Glick AB.
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis.
Carcinogenesis. 31: 1116-23, 2010.
[Journal]
31)  Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009.
[Journal]
32)  Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, Vonderhaar BK, Olson M, Watson PH, Yuspa SH.
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.
Cancer Lett. 277: 101-7, 2009.
[Journal]
33)  Cataisson C, Ohman R, Patel G, Pearson A, Tsien M, Jay S, Wright L, Hennings H, Yuspa SH.
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis.
Cancer Res. 69: 319-28, 2009.
[Journal]
34)  Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, Suh KS, Yuspa SH.
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.
Nat. Cell Biol. 11: 777-784, 2009.
[Journal]
35)  Virador VM, Flores-Obando RE, Berry A, Patel R, Zakhari J, Lo Y, Strain K, Anders J, Cataisson C, Hansen LA, Yuspa SH.
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis.
Mol. Carcinog. 48: 599-609, 2009.
[Journal]
36)  Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.
J. Immunol. 181: 1499-506, 2008.
[Journal]
37)  Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM.
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling.
Blood. 111: 3343-54, 2008.
[Journal]
38)  Lichti U, Anders J, Yuspa SH.
Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice.
Nat Protoc. 3: 799-810, 2008.
[Journal]
39)  Suh KS, Mutoh M, Mutoh T, Li L, Ryscavage A, Crutchley JM, Dumont RA, Cheng C, Yuspa SH.
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation.
J. Cell. Sci. 120: 2631-40, 2007.
[Journal]
40)  Suh KS, Malik M, Shukla A, Yuspa SH.
CLIC4, skin homeostasis and cutaneous cancer: Surprising connections.
Mol. Carcinog. 46: 599-604, 2007.
[Journal]
41)  Darwiche N, Ryscavage A, Perez-Lorenzo R, Wright L, Bae DS, Hennings H, Yuspa SH, Glick AB.
Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion.
Oncogene. 26: 6885-95, 2007.
[Journal]
42)  Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH.
Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers.
Clin. Cancer Res. 13: 121-31, 2007.
[Journal]
43)  Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH.
Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1.
J. Cell. Sci. 120: 2851-63, 2007.
[Journal]
44)  Glick A, Ryscavage A, Perez-Lorenzo R, Hennings H, Yuspa S, Darwiche N.
The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer.
Mol. Carcinog. 46: 605-10, 2007.
[Journal]
45)  Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C.
Activator protein-1 activity regulates epithelial tumor cell identity.
Cancer Res. 66: 7578-88, 2006.
[Journal]
46)  Cataisson C, Pearson AJ, Tsien MZ, Mascia F, Gao J, Pastore S, Yuspa SH.
CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation.
J. Clin. Invest. 116: 2757-66, 2006.
[Journal]
47)  Li L, Sampat K, Hu N, Zakari J, Yuspa SH.
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes.
J. Biol. Chem. 281: 3237-43, 2006.
[Journal]
48)  Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B.
Purification, crystallization and preliminary X-ray diffraction of human S100A15.
Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62: 467-70, 2006.
[Journal]
49)  Shiio Y, Suh KS, Lee H, Yuspa SH, Eisenman RN, Aebersold R.
Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4.
J. Biol. Chem. 281: 2750-6, 2006.
[Journal]
50)  Wolf R, Voscopoulos CJ, Fitzgerald PC, Goldsmith P, Cataisson C, Gunsior M, Walz M, Ruzicka T, Yuspa SH.
The Mouse S100A15 Ortholog Parallels Genomic Organization, Structure, Gene Expression, and Protein-Processing Pattern of the Human S100A7/A15 Subfamily During Epidermal Maturation.
J. Invest. Dermatol. 126: 1600-8, 2006.
[Journal]
51)  Suh KS, Mutoh M, Gerdes M, Crutchley JM, Mutoh T, Edwards LE, Dumont RA, Sodha P, Cheng C, Glick A, Yuspa SH.
Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth.
Cancer Res. 65: 562-71, 2005.
[Journal]
52)  Yuspa SH, Epstein EH.
Cancer. An anchor for tumor cell invasion.
Science. 307: 1727-8, 2005.
[Journal]
53)  Suh KS, Mutoh M, Gerdes M, Yuspa SH.
CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy.
J. Investig. Dermatol. Symp. Proc. 10: 105-9, 2005.
[Journal]
54)  Suh KS, Yuspa SH.
Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy.
Curr Pharm Des. 11: 2753-64, 2005.
[Journal]
55)  Cataisson C, Pearson AJ, Torgerson S, Nedospasov SA, Yuspa SH.
Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo.
J Immunol. 174: 1686-92, 2005.
[Journal]
56)  Bohman S, Matsumoto T, Suh K, Dimberg A, Jakobsson L, Yuspa S, Claesson-Welsh L.
Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis.
J. Biol. Chem. 280: 42397-404, 2005.
[Journal]
57)  Gerdes MJ, Yuspa SH.
The contribution of epidermal stem cells to skin cancer.
Stem Cell Rev. 1: 225-31, 2005.
[Journal]
58)  Glick AB, Yuspa SH.
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers.
Semin Cancer Biol. 15: 75-83, 2005.
[Journal]
59)  Repertinger SK, Campagnaro E, Fuhrman J, El-Abaseri T, Yuspa SH, Hansen LA.
EGFR enhances early healing after cutaneous incisional wounding.
J Invest Dermatol. 123: 982-9, 2004.
[Journal]
60)  Woodworth CD, Michael E, Smith L, Vijayachandra K, Glick A, Hennings H, Yuspa SH.
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte.
Carcinogenesis. 25: 1771-8, 2004.
[Journal]
61)  Suh KS, Mutoh M, Nagashima K, Fernandez-Salas E, Edwards LE, Hayes DD, Crutchley JM, Marin KG, Dumont RA, Levy JM, Cheng C, Garfield S, Yuspa SH.
The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis.
J Biol Chem. 279: 4632-41, 2004.
[Journal]
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This page was last updated on 11/25/2013.