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Our Science – Yu Website

Yan Lin Yu, Ph.D.

Selected Publications

1)  Yu Y, Zeng P, Xiong J, Liu Z, Berger SL, Merlino G.
Epigenetic Drugs Can Stimulate Metastasis through Enhanced Expression of the Pro-Metastatic Ezrin Gene.
PloS one. 5, 2010.
2)  Yu Y, Merlino G.
Roles for aberrant CXCR3 signaling in basal cell carcinoma: a case for dual activity.
Am. J. Pathol. 176: 2088-91, 2010.
3)  Taylor JG, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J.
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.
J. Clin. Invest. 119: 3395-407, 2009.
4)  Yu Y, Davicioni E, Triche TJ, Merlino G.
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.
Cancer Res. 66: 1982-9, 2006.
5)  Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Nat. Med. 10: 175-81, 2004.
6)  Yan J, Yu Y, Wang N, Chang Y, Ying H, Liu W, He J, Li S, Jiang W, Li Y, Liu H, Wang H, Xu Y.
LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma.
Oncogene. 23: 1939-49, 2004.
7)  Yu Y, Merlino G.
Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model.
Cancer Res. 62: 2951-6, 2002.
8)  Sharp R, Recio JA, Jhappan C, Otsuka T, Liu S, Yu Y, Liu W, Anver M, Navid F, Helman LJ, DePinho RA, Merlino G.
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.
Nat. Med. 8: 1276-80, 2002.
Click Here to View Expanded Bibliography.

This page was last updated on 7/11/2014.