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Our Science – Merlino Website

Glenn Merlino, Ph.D.

Selected Publications

1)  Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT.
TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.
Cell. 61: 1137-46, 1990.
[Journal]
2)  Noonan FP, Recio JA, Takayama H, Duray P, Anver MR, Rush WL, De Fabo EC, Merlino G.
Neonatal sunburn and melanoma in mice.
Nature. 413: 271-2, 2001.
[Journal]
3)  Sharp R, Recio JA, Jhappan C, Otsuka T, Liu S, Yu Y, Liu W, Anver M, Navid F, Helman LJ, DePinho RA, Merlino G.
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.
Nat. Med. 8: 1276-80, 2002.
[Journal]
4)  Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Nat Med. 10: 175-81, 2004.
[Journal]
5)  Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G.
Interferon-gamma links ultraviolet radiation to melanomagenesis in mice.
Nature. 469: 548-53, 2011.
[Journal]
6)  Wolnicka-Glubisz A, Strickland FM, Wielgus A, Anver M, Merlino G, De Fabo EC, Noonan FP.
A melanin-independent interaction between Mc1r and Met signaling pathways is required for HGF-dependent melanoma.
Int. J. Cancer. 2014.
[Journal]
7)  Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS.
Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry.
Cancer Cell. 25: 831-45, 2014.
[Journal]
8)  Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton P, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Janeway KA, Weigel BJ, Randall RL, Meltzer PS, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Uren A, Patel S, Trent JM, Savage SA, Mirabello L, Reinke D, Barkauskas DA, Smith MA, Bernstein ML, Kirsch DG, Krailo MD.
Towards a Drug Development Path that Targets Metastatic Progression in Osteosarcoma.
Clin. Cancer Res. [Epub ahead of print], 2014.
[Journal]
9)  Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, Robinson KC, Van Otterloo E, Kim RS, Bergsteinsdottir K, Ogmundsdottir MH, Magnusdottir E, Mishra PJ, Davis SR, Guo T, Zaidi MR, Helgason AS, Sigurdsson MI, Meltzer PS, Merlino G, Petit V, Larue L, Loftus SK, Adams DR, Sobhiafshar U, Emre NC, Pavan WJ, Cornell R, Smith AG, McCallion AS, Fisher DE, Stefansson K, Sturm RA, Steingrimsson E.
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.
Cell. 155: 1022-33, 2013.
[Journal]
10)  Wilson W, Merlino G.
Flipping the phenotypic switch on a novel antimelanoma differentiation strategy.
Pigment Cell Melanoma Res. 26: 791-3, 2013.
[Journal]
11)  Merlino G, Flaherty K, Acquavella N, Day C, Aplin A, Holmen S, Topalian S, Van Dyke T, Herlyn M.
Meeting report: The future of preclinical mouse models in melanoma treatment is now.
Pigment Cell Melanoma Res. 26: E8-E14, 2013.
[Journal]
12)  Jarrett SG, Novak M, Harris N, Merlino G, Slominski A, Kaetzel DM.
NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma.
Clin Exp Metastasis. 30: 25-36, 2013.
[Journal]
13)  Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL.
Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa.
PLoS ONE. 8: e57389, 2013.
[Journal]
14)  Van Dyke T, Merlino G.
Beta-catenin in metastatic melanoma--the smoking gun reloaded.
Pigment Cell Melanoma Res. 25: 125-6, 2012.
[Journal]
15)  Debbache J, Raza Zaidi M, Davis S, Guo T, Bismuth K, Wang X, Skuntz S, Maric D, Pickel J, Meltzer P, Merlino G, Arnheiter H.
In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.
Genetics. 191: 133-44, 2012.
[Journal]
16)  Noonan FP, Zaidi MR, Wolnicka-Glubisz A, Anver MR, Bahn J, Wielgus A, Cadet J, Douki T, Mouret S, Tucker MA, Popratiloff A, Merlino G, De Fabo EC.
Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment.
Nat Commun. 3: 884, 2012.
[Journal]
17)  Wright LN, Ryscavage A, Merlino G, Yuspa SH.
Modeling the transcriptional consequences of epidermal growth factor receptor ablation in Ras-initiated squamous cancer.
Clin. Cancer Res. 18: 170-83, 2012.
[Journal]
18)  Day C, Carter J, Bonomi C, Hollingshead M, Merlino G.
Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
Int J Cancer. 130: 190-9, 2012.
[Journal]
19)  Zaidi MR, De Fabo EC, Noonan FP, Merlino G.
Shedding light on melanocyte pathobiology in vivo.
Cancer Res. 72: 1591-5, 2012.
[Journal]
20)  Merlino G.
Unraveling the melanoma pathogenome.
Pigment Cell Melanoma Res. 25: 121, 2012.
[Journal]
21)  Zaidi MR, Hornyak TJ, Merlino G.
A genetically engineered mouse model with inducible GFP expression in melanocytes.
Pigment Cell Melanoma Res. 24: 393-4, 2011.
[Journal]
22)  Zaidi MR, Day CP, Merlino G.
Fluorescent protein-assisted purification for gene expression profiling.
Methods Mol. Biol. 699: 393-405, 2011.
[Journal]
23)  Day CP, Merlino G.
Illuminating progression: tracking melanoma metastasis in a gene therapy setting.
Pigment Cell Melanoma Res. 24: 260-1, 2011.
[Journal]
24)  Meadors JL, Cui Y, Chen Q, Song YK, Khan J, Merlino G, Tsokos M, Orentas RJ, Mackall CL.
Murine rhabdomyosarcoma is immunogenic and responsive to T-cell-based immunotherapy.
Pediatr Blood Cancer. 57: 921-9, 2011.
[Journal]
25)  Andreu-Pérez P, Esteve-Puig R, de Torre-Minguela C, López-Fauqued M, Bech-Serra JJ, Tenbaum S, García-Trevijano ER, Canals F, Merlino G, Avila MA, Recio JA.
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
Sci Signal. 4: ra58, 2011.
[Journal]
26)  Zaidi MR, Merlino G.
The Two Faces of Interferon-{gamma} in cancer.
Clin Cancer Res. 17: 6118-24, 2011.
[Journal]
27)  Mishra PJ, Ha L, Rieker J, Sviderskaya EV, Bennett DC, Oberst MD, Kelly K, Merlino G.
Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Oncogene. 29: 2449-56, 2010.
[Journal]
28)  Yu Y, Zeng P, Xiong J, Liu Z, Berger SL, Merlino G.
Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene.
PLoS ONE. 5: e12710, 2010.
[Journal]
29)  Fisher DE, Barnhill R, Hodi FS, Herlyn M, Merlino G, Medrano E, Bastian B, Landi MT, Landi TM, Sosman J.
Melanoma from bench to bedside: meeting report from the 6th international melanoma congress.
Pigment Cell Melanoma Res. 23: 14-26, 2010.
[Journal]
30)  Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir el H, Dakir el-H, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
Modeling metastasis biology and therapy in real time in the mouse lung.
J. Clin. Invest. 120: 2979-88, 2010.
[Journal]
31)  Yu Y, Merlino G.
Roles for aberrant CXCR3 signaling in basal cell carcinoma: a case for dual activity.
Am. J. Pathol. 176: 2088-91, 2010.
[Journal]
32)  Klug HL, Tooze JA, Graff-Cherry C, Anver MR, Noonan FP, Fears TR, Tucker MA, De Fabo EC, Merlino G.
Sunscreen prevention of melanoma in man and mouse.
Pigment Cell Melanoma Res. 23: 835-7, 2010.
[Journal]
33)  Merlino G.
Building the perfect beast: complex mouse models teach surprisingly simple melanoma lessons.
Pigment Cell Melanoma Res. 22: 246-7, 2009.
[Journal]
34)  Taylor JG, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J.
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.
J. Clin. Invest. 119: 3395-407, 2009.
[Journal]
35)  Day C, Carter J, Bonomi C, Esposito D, Crise B, Ortiz-Conde B, Hollingshead M, Merlino G.
Lentivirus-mediated bifunctional cell labeling for in vivo melanoma study.
Pigment Cell Melanoma Res. 22: 283-95, 2009.
[Journal]
36)  Mishra PJ, Merlino G.
MicroRNA reexpression as differentiation therapy in cancer.
J. Clin. Invest. 119: 2119-23, 2009.
[Journal]
37)  Mishra PJ, Song B, Mishra PJ, Wang Y, Humeniuk R, Banerjee D, Merlino G, Ju J, Bertino JR.
MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.
PLoS ONE. 4: e8445, 2009.
[Journal]
38)  Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velásquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ.
Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.
Am. J. Hum. Genet. 85: 25-39, 2009.
[Journal]
39)  Esteve-Puig R, Canals F, Colomé N, Merlino G, Recio JA.
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF.
PLoS ONE. 4: e4771, 2009.
[Journal]
40)  Mishra PJ, Merlino G.
A traitor in our midst: mesenchymal stem cells contribute to tumor progression and metastasis.
Future Oncol. 4: 745-9, 2008.
[Journal]
41)  Zaidi MR, Day CP, Merlino G.
From UVs to metastases: modeling melanoma initiation and progression in the mouse.
J. Invest. Dermatol. 128: 2381-91, 2008.
[Journal]
42)  Calvo A, Catena R, Noble MS, Carbott D, Gil-Bazo I, Gonzalez-Moreno O, Huh J, Sharp R, Qiu T, Anver MR, Merlino G, Dickson RB, Johnson MD, Green JE.
Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis.
Oncogene. 27: 5373-84, 2008.
[Journal]
43)  Fisher DE, Medrano EE, McMahon M, Soengas MS, Schuchter L, Wolchok JD, Merlino G.
Meeting report: fourth international congress of the Society for Melanoma Research.
Pigment Cell Melanoma Res. 21: 15-26, 2008.
[Journal]
44)  Ha L, Merlino G, Sviderskaya EV.
Melanomagenesis: overcoming the barrier of melanocyte senescence.
Cell Cycle. 7: 1944-8, 2008.
[Journal]
45)  Merlino G.
The ARFul truth about melanoma susceptibility genes.
Pigment Cell Melanoma Res. 21: 503-4, 2008.
[Journal]
46)  Varticovski L, Hollingshead MG, Robles AI, Wu X, Cherry J, Munroe DJ, Lukes L, Anver MR, Carter JP, Borgel SD, Stotler H, Bonomi CA, Nunez NP, Hursting SD, Qiao W, Deng CX, Green JE, Hunter KW, Merlino G, Steeg PS, Wakefield LM, Barrett JC.
Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models.
Clin. Cancer Res. 13: 2168-77, 2007.
[Journal]
47)  Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G.
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Proc. Natl. Acad. Sci. U.S.A. 104: 10968-73, 2007.
[Journal]
48)  Merlino G, Khanna C.
Fishing for the origins of cancer.
Genes Dev. 21: 1275-9, 2007.
[Journal]
49)  Gareau DS, Merlino G, Corless C, Kulesz-Martin M, Jacques SL.
Noninvasive Imaging of Melanoma with Reflectance Mode Confocal Scanning Laser Microscopy in a Murine Model.
J Invest Dermatol. 127: 2184-90, 2007.
[Journal]
50)  Booth BW, Jhappan C, Merlino G, Smith GH.
TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium.
Int. J. Cancer. 120: 493-9, 2007.
[Journal]
51)  Puatanachokchai R, Kakuni M, Wanibuchi H, Kinoshita A, Kang JS, Salim EI, Morimura K, Tamano S, Merlino GT, Fukushima S.
Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice.
Asian Pac. J. Cancer Prev. 7: 274-8, 2006.
[Journal]
52)  Tormo D, Ferrer A, Gaffal E, Wenzel J, Basner-Tschakarjan E, Steitz J, Heukamp LC, Gutgemann I, Buettner R, Malumbres M, Barbacid M, Merlino G, Tuting T.
Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.
Am. J. Pathol. 169: 665-72, 2006.
[Journal]
53)  Yu Y, Davicioni E, Triche TJ, Merlino G.
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.
Cancer Res. 66: 1982-9, 2006.
[Journal]
54)  Ha L, Noonan FP, De Fabo EC, Merlino G.
Animal models of melanoma.
J. Investig. Dermatol. Symp. Proc. 10: 86-8, 2005.
[Journal]
55)  Merlino G.
Cancer biology: the weakest link?.
Nature. 436: 33-5, 2005.
[Journal]
56)  Gareau DS, Lagowski J, Rossi VM, Viator JA, Merlino G, Kulesz-Martin M, Jacques SL.
Imaging melanoma in a murine model using reflectance-mode confocal scanning laser microscopy and polarized light imaging.
J. Investig. Dermatol. Symp. Proc. 10: 164-9, 2005.
[Journal]
57)  Otsuka T, Horiguchi N, Kanda D, Kosone T, Yamazaki Y, Yuasa K, Sohara N, Kakizaki S, Sato K, Takagi H, Merlino G, Mori M.
Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice.
World J. Gastroenterol. 11: 7444-9, 2005.
[Journal]
58)  Schoeffner DJ, Matheny SL, Akahane T, Factor V, Berry A, Merlino G, Thorgeirsson UP.
VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms.
Lab Invest. 85: 608-23, 2005.
[Journal]
59)  Demierre MF, Merlino G.
Chemoprevention of melanoma.
Curr Oncol Rep. 6: 406-13, 2004.
[Journal]
60)  De Fabo EC, Noonan FP, Fears T, Merlino G.
Ultraviolet B but not ultraviolet A radiation initiates melanoma.
Cancer Res. 64: 6372-6, 2004.
[Journal]
61)  Recio JA, Merlino G.
Hepatocyte growth factor/scatter factor induces feedback up-regulation of CD44v6 in melanoma cells through Egr-1.
Cancer Res. 63: 1576-82, 2003.
[Journal]
62)  Merlino G, Noonan FP.
Modeling gene-environment interactions in malignant melanoma.
Trends Mol Med. 9: 102-8, 2003.
[Journal]
63)  Jhappan C, Noonan FP, Merlino G.
Ultraviolet radiation and cutaneous malignant melanoma.
Oncogene. 22: 3099-112, 2003.
[Journal]
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This page was last updated on 8/11/2014.