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Our Science – Stuelten Website

Christina H. Stuelten, M.D., Ph.D.

Selected Publications

1)  Weiger MC, Vedham V, Stuelten CH, Shou K, Herrera M, Sato M, Losert W, Parent CA.
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.
PLoS ONE. 8: e58859, 2013.
[Journal]
2)  Stuelten CH, Cervoni-Curet FN, Busch JI, Sutton E, Webster JD, Kavalukas SL, Wakefield LM, Barbul A, Niederhuber JE.
SDF-1a mediates wound-promoted tumor growth in a syngeneic orthotopic mouse model of breast cancer.
PLoS ONE. 8: e60919, 2013.
[Journal]
3)  Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM.
Biological responses to TGF-ß in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.
Mol. Cancer Res. 10: 1389-99, 2012.
[Journal]
4)  Fleming JM, Miller TC, Kidacki M, Ginsburg E, Stuelten CH, Stewart DA, Troester MA, Vonderhaar BK.
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo.
Breast Cancer Res. 14: R97, 2012.
[Journal]
5)  Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling.
Cell Metab. 14: 67-79, 2011.
[Journal]
6)  Peskin AP, Hoeppner DJ, Stuelten CH.
Segmentation and Cell Tracking of Breast Cancer Cells (ISVC).
Volume 2011 (1). p. 381-391. [Meeting Proceeding]
7)  Kohn EA, Du Z, Sato M, Van Schyndle CM, Welsh MA, Yang YA, Stuelten CH, Tang B, Ju W, Bottinger EP, Wakefield LM.
A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland.
Breast cancer research : BCR. 12: R83, 2010.
[Journal]
8)  Pastar I, Stojadinovic O, Krzyzanowska A, Barrientos S, Stuelten C, Zimmerman K, Blumenberg M, Brem H, Tomic-Canic M.
Attenuation of the transforming growth factor beta-signaling pathway in chronic venous ulcers.
Mol. Med. 16: 92-101, 2010.
[Journal]
9)  Stuelten CH, Mertins SD, Busch JI, Gowens M, Scudiero DA, Burkett MW, Hite KM, Alley M, Hollingshead M, Shoemaker RH, Niederhuber JE.
Complex display of putative tumor stem cell markers in the NCI60 tumor cell line panel.
Stem Cells. 28: 649-60, 2010.
[Journal]
10)  Stuelten CH, Salomon DS.
miR-31 in cancer: location matters.
Cell Cycle. 9: 4608-9, 2010.
[Journal]
11)  Xu L, Kitani A, Stuelten C, McGrady G, Fuss I, Strober W.
Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I.
Immunity. 33: 313-25, 2010.
[Journal]
12)  Stuelten CH, Busch JI, Tang B, Flanders KC, Oshima A, Sutton E, Karpova TS, Roberts AB, Wakefield LM, Niederhuber JE.
Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-Beta mediated mechanism in a mouse xenograft model of breast cancer.
PLoS ONE. 5: e9832, 2010.
[Journal]
13)  Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H.
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
J. Exp. Med. 206: 2131-9, 2009.
[Journal]
14)  Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB.
Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.
Am. J. Pathol. 173: 68-76, 2008.
[Journal]
15)  Stuelten CH, Barbul A, Busch JI, Sutton E, Katz R, Sato M, Wakefield LM, Roberts AB, Niederhuber JE.
Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism.
Cancer Res. 68: 7278-82, 2008.
[Journal]
16)  Nam JS, Terabe M, Mamura M, Kang MJ, Chae H, Stuelten C, Kohn E, Tang B, Sabzevari H, Anver MR, Lawrence S, Danielpour D, Lonning S, Berzofsky JA, Wakefield LM.
An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.
Cancer Res. 68: 3835-43, 2008.
[Journal]
17)  Wakefield LM, Stuelten C.
Keeping order in the neighborhood: new roles for TGFbeta in maintaining epithelial homeostasis.
Cancer Cell. 12: 293-5, 2007.
[Journal]
18)  Stuelten CH, Kamaraju AK, Wakefield LM, Roberts AB.
Lentiviral reporter constructs for fluorescence tracking of the temporospatial pattern of Smad3 signaling.
BioTechniques. 43: 289-90, 292, 294, 2007.
[Journal]
19)  Nam JS, Suchar AM, Kang MJ, Stuelten CH, Tang B, Michalowska AM, Fisher LW, Fedarko NS, Jain A, Pinkas J, Lonning S, Wakefield LM.
Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.
Cancer Res. 66: 6327-35, 2006.
[Journal]
20)  Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten C, Desai KV, Tuan R, Rennard SI, Roberts AB.
Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.
Proc. Natl. Acad. Sci. U.S.A. 103: 9250-5, 2006.
[Journal]
21)  Stuelten CH, Buck MB, Dippon J, Roberts AB, Fritz P, Knabbe C.
Smad4-expression is decreased in breast cancer tissues: a retrospective study.
BMC Cancer. 6: 25, 2006.
[Journal]
22)  Kimmel M, Alscher DM, Dunst R, Braun N, Machleidt C, Kiefer T, Stülten C, van der Kuip H, Pauli-Magnus C, Raub U, Kuhlmann U, Mettang T.
The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients.
Nephrol. Dial. Transplant. 21: 749-55, 2006.
[Journal]
23)  Stuelten CH, DaCosta Byfield S, Arany PR, Karpova TS, Stetler-Stevenson WG, Roberts AB.
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta.
J. Cell. Sci. 118: 2143-53, 2005.
[Journal]
24)  Bi Y, Stuelten CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG, Chen XD, Young MF.
Extracellular matrix proteoglycans control the fate of bone marrow stromal cells.
J. Biol. Chem. 280: 30481-9, 2005.
[Journal]
25)  Alscher DM, Braun N, Biegger D, Stuelten C, Gawronski K, Mürdter TE, Kuhlmann U, Fritz P.
Induction of metallothionein in proximal tubular cells by zinc and its potential as an endogenous antioxidant.
Kidney Blood Press. Res. 28: 127-33, 2005.
[Journal]
26)  Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, Saika S, Flanders KC.
Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis.
Cytokine Growth Factor Rev. 17: 19-27, 2005.
[Journal]
27)  Tian F, Byfield SD, Parks WT, Stuelten CH, Nemani D, Zhang YE, Roberts AB.
Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines.
Cancer Res. 64: 4523-30, 2004.
[Journal]
28)  Witte MB, Vogt N, Stuelten C, Gotoh T, Mori M, Becker HD.
Arginase acts as an alternative pathway of L-arginine metabolism in experimental colon anastomosis.
J. Gastrointest. Surg. 7: 378-85, 2003.
[Journal]
29)  Schäffer M, Weimer W, Wider S, Stülten C, Bongartz M, Budach W, Becker HD.
Differential expression of inflammatory mediators in radiation-impaired wound healing.
J. Surg. Res. 107: 93-100, 2002.
[Journal]
30)  Lee RH, Efron DT, Tantry U, Stuelten C, Moldawer LL, Abouhamze A, Barbul A.
Inhibition of tumor necrosis factor-alpha attenuates wound breaking strength in rats.
Wound Repair Regen. 8: 547-53, 2001.
[Journal]
31)  Efron DT, Thornton FJ, Steulten C, Tantry US, Witte MB, Kiyama T, Barbul A.
Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing.
J. Gastrointest. Surg. 3: 592-601, 1999.
[Journal]
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This page was last updated on 8/8/2013.