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Our Science – Shankavaram Website

Uma T. Shankavaram, Ph.D.

Selected Publications

1)  Dan T, Hewitt SM, Ohri N, Ly D, Soule BP, Smith SL, Matsuda K, Council C, Shankavaram U, Lippman ME, Mitchell JB, Camphausen K, Simone NL.
CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up.
Breast Cancer Res. Treat. 143: 11-8, 2014.
[Journal]
2)  Hayman TJ, Wahba A, Rath BH, Bae H, Kramp T, Shankavaram UT, Camphausen K, Tofilon PJ.
The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.
Clin. Cancer Res. 20: 110-9, 2014.
[Journal]
3)  Ho J, Ondos J, Ning H, Smith S, Kreisl T, Iwamoto F, Sul J, Kim L, McNeil K, Krauze A, Shankavaram U, Fine HA, Camphausen K.
Chemoirradiation for glioblastoma multiforme: the national cancer institute experience.
PLoS ONE. 8: e70745, 2013.
[Journal]
4)  Sproull M, Avondoglio D, Kramp T, Shankavaram U, Camphausen K.
Correlation of plasma FL expression with bone marrow irradiation dose.
PLoS ONE. 8: e58558, 2013.
[Journal]
5)  Shankavaram U, Fliedner SM, Elkahloun AG, Barb JJ, Munson PJ, Huynh TT, Matro JC, Turkova H, Linehan WM, Timmers HJ, Tischler AS, Powers JF, de Krijger R, Baysal BE, Takacova M, Pastorekova S, Gius D, Lehnert H, Camphausen K, Pacak K.
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Neoplasia. 15: 435-47, 2013.
[Journal]
6)  Tandle AT, Kramp T, Kil WJ, Halthore A, Gehlhaus K, Shankavaram U, Tofilon PJ, Caplen NJ, Camphausen K.
Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.
Eur. J. Cancer. 49: 3020-8, 2013.
[Journal]
7)  Citrin DE, Shankavaram U, Horton JA, Shield W, Zhao S, Asano H, White A, Sowers A, Thetford A, Chung EJ.
Role of type II pneumocyte senescence in radiation-induced lung fibrosis.
J. Natl. Cancer Inst. 105: 1474-84, 2013.
[Journal]
8)  Portal-Nuñez S, Shankavaram UT, Rao M, Datrice N, Atay S, Aparicio M, Camphausen KA, Fernández-Salguero PM, Chang H, Lin P, Schrump DS, Garantziotis S, Cuttitta F, Zudaire E.
Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.
Cancer Res. 72: 5790-800, 2012.
[Journal]
9)  Johnson S, Issac B, Zhao S, Bisht M, Celiku O, Tofilon P, Camphausen K, Shankavaram U.
StRAP: An Integrated Resource for Profiling High-Throughput Cancer Genomic Data from Stress Response Studies.
PLoS ONE. 7: e51693, 2012.
[Journal]
10)  Hayman TJ, Williams ES, Jamal M, Shankavaram UT, Camphausen K, Tofilon PJ.
Translation initiation factor eIF4E is a target for tumor cell radiosensitization.
Cancer Res. 72: 2362-72, 2012.
[Journal]
11)  Shankavaram UT, Bredel M, Burgan WE, Carter D, Tofilon P, Camphausen K.
Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma.
Journal of cellular and molecular medicine. 2011.
[Journal]
12)  Stall B, Zach L, Ning H, Ondos J, Arora B, Shankavaram U, Miller RW, Citrin D, Camphausen K.
Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas.
Radiat Oncol. 5: 5, 2010.
[Journal]
13)  Lu JJ, Meng LH, Shankavaram UT, Zhu CH, Tong LJ, Chen G, Lin LP, Weinstein JN, Ding J.
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells.
Biochem. Pharmacol. 80: 22-30, 2010.
[Journal]
14)  Brown AP, Chung EJ, Urick ME, Shield WP, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.
Evaluation of the fullerene compound DF-1 as a radiation protector.
Radiat Oncol. 5: 34, 2010.
[Journal]
15)  Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.
Multifactorial Regulation of E-Cadherin Expression: An Integrative Study.
Molecular cancer therapeutics. 2010.
[Journal]
16)  Housri N, Ning H, Ondos J, Choyke P, Camphausen K, Citrin D, Arora B, Shankavaram U, Kaushal A.
Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men with Localized Prostate Cancer.
Int. J. Radiat. Oncol. Biol. Phys. 2010.
[Journal]
17)  Zach L, Stall B, Ning H, Ondos J, Arora B, Uma S, Miller RW, Citrin D, Camphausen K.
A dosimetric comparison of four treatment planning methods for high grade glioma.
Radiation oncology (London, England). 4: 45, 2009.
[Journal]
18)  Shankavaram UT, Varma S, Kane D, Sunshine M, Chary KK, Reinhold WC, Pommier Y, Weinstein JN.
CellMiner: a relational database and query tool for the NCI-60 cancer cell lines.
BMC Genomics. 10: 277, 2009.
[Journal]
19)  McCord AM, Jamal M, Shankavaram UT, Shankavarum UT, Lang FF, Camphausen K, Tofilon PJ.
Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.
Mol. Cancer Res. 7: 489-97, 2009.
[Journal]
20)  Russo AL, Jedlicka K, Wernick M, McNally D, Kirk M, Sproull M, Smith S, Shankavaram U, Kaushal A, Figg WD, Dahut W, Citrin D, Bottaro DP, Albert PS, Tofilon PJ, Camphausen K.
Urine analysis and protein networking identify met as a marker of metastatic prostate cancer.
Clin. Cancer Res. 15: 4292-8, 2009.
[Journal]
21)  Kumaraswamy S, Chinnaiyan P, Shankavaram UT, Lu X, Camphausen K, Tofilon PJ.
Radiation-induced gene translation profiles reveal tumor type and cancer-specific components.
Cancer Res. 68: 3819-26, 2008.
[Journal]
22)  Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN.
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.
Mol. Cancer Ther. 6: 391-403, 2007.
[Journal]
23)  Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y.
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.
Cancer Res. 67: 8752-61, 2007.
[Journal]
24)  Shankavaram UT, Reinhold WC, Nishizuka S, Major S, Morita D, Chary KK, Reimers MA, Scherf U, Kahn A, Dolginow D, Cossman J, Kaldjian EP, Scudiero DA, Petricoin E, Liotta L, Lee JK, Weinstein JN.
Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study.
Mol. Cancer Ther. 6: 820-32, 2007.
[Journal]
25)  Major SM, Nishizuka S, Morita D, Rowland R, Sunshine M, Shankavaram U, Washburn F, Asin D, Kouros-Mehr H, Kane D, Weinstein JN.
AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies.
BMC Bioinformatics. 7: 192, 2006.
[Journal]
26)  Meng LH, Shankavaram U, Chen C, Agama K, Fu HQ, Gonzalez FJ, Weinstein J, Pommier Y.
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.
Cancer Res. 66: 9656-64, 2006.
[Journal]
27)  Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Mol. Cancer Ther. 5: 2613-23, 2006.
[Journal]
28)  Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadée W.
Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance.
Cancer Res. 64: 4294-301, 2004.
[Journal]
29)  Szakács G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM.
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells.
Cancer Cell. 6: 129-37, 2004.
[Journal]
30)  Lee JK, Bussey KJ, Gwadry FG, Reinhold W, Riddick G, Pelletier SL, Nishizuka S, Szakacs G, Annereau JP, Shankavaram U, Lababidi S, Smith LH, Gottesman MM, Weinstein JN.
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells.
Genome Biol. 4: R82, 2003.
[Journal]
31)  Lai WC, Zhou M, Shankavaram U, Peng G, Wahl LM.
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
J. Immunol. 170: 6244-9, 2003.
[Journal]
32)  Shankavaram UT, Lai WC, Netzel-Arnett S, Mangan PR, Ardans JA, Caterina N, Stetler-Stevenson WG, Birkedal-Hansen H, Wahl LM.
Monocyte membrane type 1-matrix metalloproteinase. Prostaglandin-dependent regulation and role in metalloproteinase-2 activation.
J. Biol. Chem. 276: 19027-32, 2001.
[Journal]
33)  Tatusov RL, Natale DA, Garkavtsev IV, Tatusova TA, Shankavaram UT, Rao BS, Kiryutin B, Galperin MY, Fedorova ND, Koonin EV.
The COG database: new developments in phylogenetic classification of proteins from complete genomes.
Nucleic Acids Res. 29: 22-8, 2001.
[Journal]
34)  Natale DA, Shankavaram UT, Galperin MY, Wolf YI, Aravind L, Koonin EV.
Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs).
Genome Biol. 1: RESEARCH0009, 2000.
[Journal]
35)  Boykins RA, Mahieux R, Shankavaram UT, Gho YS, Lee SF, Hewlett IK, Wahl LM, Kleinman HK, Brady JN, Yamada KM, Dhawan S.
Cutting edge: a short polypeptide domain of HIV-1-Tat protein mediates pathogenesis.
J. Immunol. 163: 15-20, 1999.
[Journal]
36)  Shankavaram UT, DeWitt DL, Wahl LM.
Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by the tyrosine phosphorylation of cytosolic phospholipase A2.
J. Leukoc. Biol. 64: 221-7, 1998.
[Journal]
37)  Shankavaram UT, DeWitt DL, Funk SE, Sage EH, Wahl LM.
Regulation of human monocyte matrix metalloproteinases by SPARC.
J. Cell. Physiol. 173: 327-34, 1997.
[Journal]
38)  Wahl LM, Shankavaram U, Zhang Y.
Role of macrophages in vascular tissue remodelling.
Transpl. Immunol. 5: 173-6, 1997.
[Journal]
39)  Miller BS, Shankavaram UT, Horney MJ, Gore AC, Kurtz DT, Rosenzweig SA.
Activation of cJun NH2-terminal kinase/stress-activated protein kinase by insulin.
Biochemistry. 35: 8769-75, 1996.
[Journal]
40)  Rosenzweig SA, Oemar BS, Law NM, Shankavaram UT, Miller BS.
Insulin like growth factor 1 receptor signal transduction to the nucleus.
Adv. Exp. Med. Biol. 343: 159-68, 1993.
[Journal]
41)  Studzinski GP, Shankavaram UT, Moore DC, Reddy PV.
Association of c-myc protein with enzymes of DNA replication in high molecular weight fractions from mammalian cells.
J. Cell. Physiol. 147: 412-9, 1991.
[Journal]
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This page was last updated on 3/11/2014.