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Our Science – Edelman Website

Daniel C. Edelman, Ph.D.

Selected Publications
1)  Azad N, Yu M, Davidson B, Choyke P, Chen CC, Wood BJ, Venkatesan A, Henning R, Calvo K, Minasian L, Edelman DC, Meltzer P, Steinberg SM, Annunziata CM, Kohn EC.
Translational predictive biomarker analysis of the phase 1b sorafenib and bevacizumab study expansion cohort.
Mol. Cell Proteomics. [Epub ahead of print], 2013. [Journal]
2)  Rechache NS, Wang Y, Stevenson HS, Killian JK, Edelman DC, Merino M, Zhang L, Nilubol N, Stratakis CA, Meltzer PS, Kebebew E.
DNA Methylation Profiling Identifies Global Methylation Differences and Markers of Adrenocortical Tumors.
J Clin Endocrinol Metab. 97: E1004-13, 2012. [Journal]
3)  Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS.
Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples.
Methods Mol. Biol. 823: 107-18, 2012. [Journal]
4)  Warren KE, Killian K, Suuriniemi M, Wang Y, Quezado M, Meltzer PS.
Genomic aberrations in pediatric diffuse intrinsic pontine gliomas.
Neuro Oncology. 14: 326-32, 2012. [Journal]
5)  Nader N, Ng SS, Wang Y, Abel BS, Chrousos GP, Kino T.
Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.
PLoS ONE. 7: e26751, 2012. [Journal]
6)  Lee JH, Giovannetti E, Hwang JH, Petrini I, Wang Q, Voortman J, Wang Y, Steinberg SM, Funel N, Meltzer PS, Wang Y, Giaccone G.
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Clin. Cancer Res. 18: 524-33, 2012. [Journal]
7)  Killian JK, Bilke S, Davis S, Walker RL, Jaeger E, Killian MS, Waterfall JJ, Bibikova M, Fan JB, Smith WI, Meltzer PS.
A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology.
Am. J. Pathol. 179: 55-65, 2011. [Journal]
8)  Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome Res. 21: 1822-32, 2011. [Journal]
9)  Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D.
Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
Clin. Exp. Metastasis. 28: 899-908, 2011. [Journal]
10)  Eberle FC, Rodriguez-Canales J, Wei L, Hanson JC, Killian JK, Sun HW, Adams LG, Hewitt SM, Wilson WH, Pittaluga S, Meltzer PS, Staudt LM, Emmert-Buck MR, Jaffe ES.
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.
Haematologica. 96: 558-66, 2011. [Journal]
11)  Valenzuela MS, Chen Y, Davis S, Yang F, Walker RL, Bilke S, Lueders J, Martin MM, Aladjem MI, Massion PP, Meltzer PS.
Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences.
PLoS ONE. 6: e17308, 2011. [Journal]
12)  Nader N, Ng SS, Lambrou GI, Pervanidou P, Wang Y, Chrousos GP, Kino T.
AMPK Regulates Metabolic Actions of Glucocorticoids by Phosphorylating the Glucocorticoid Receptor through p38 MAPK.
Mol. Endocrinol. 24: 1748-64, 2010. [Journal]
13)  Killian JK, Walker RL, Suuriniemi M, Jones L, Scurci S, Singh P, Cornelison R, Harmon S, Boisvert N, Zhu J, Wang Y, Bilke S, Davis S, Giaccone G, Smith WI, Meltzer PS.
Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling.
J Mol Diagn. 12: 739-45, 2010. [Journal]
14)  Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI, Meltzer P, Wang Y, Giaccone G.
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proc. Natl. Acad. Sci. U.S.A. 107: 13040-5, 2010. [Journal]
15)  Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, Rao M, Meltzer PA, Schrump DS.
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.
Oncogene. 29: 3650-64, 2010. [Journal]
16)  Cao L, Yu Y, Bilke S, Walker RL, Mayeenuddin LH, Azorsa DO, Yang F, Pineda M, Helman LJ, Meltzer PS.
Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.
Cancer Res. 70: 6497-508, 2010. [Journal]
17)  Eberle FC, Hanson JC, Killian JK, Wei L, Ylaya K, Hewitt SM, Jaffe ES, Emmert-Buck MR, Rodriguez-Canales J.
Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens.
J Mol Diagn. 12: 394-401, 2010. [Journal]
18)  Killian JK.
Large-scale molecular profiling of the cancer tissue methylome. In: Methods in Molecular Biology: Individualized Molecular Medicine.
Humana Press; 2009. In Press. [Book Chapter]
19)  Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH.
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Sci Signal. 2: ra5, 2009. [Journal]
20)  Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Proc. Natl. Acad. Sci. U.S.A. 106: 19286-91, 2009. [Journal]
21)  Kino T, Manoli I, Kelkar S, Wang Y, Su YA, Chrousos GP.
Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.
Biochem. Biophys. Res. Commun. 381: 671-5, 2009. [Journal]
22)  Killian JK, Bilke S, Davis S, Walker RL, Killian MS, Jaeger EB, Chen Y, Hipp J, Pittaluga S, Raffeld M, Cornelison R, Smith WI, Bibikova M, Fan JB, Emmert-Buck MR, Jaffe ES, Meltzer PS.
Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome.
Cancer Res. 69: 758-64, 2009. [Journal]
23)  Kralj JG, Player A, Sedrick H, Munson MS, Petersen D, Forry SP, Meltzer P, Kawasaki E, Locascio LE.
T7-based linear amplification of low concentration mRNA samples using beads and microfluidics for global gene expression measurements.
Lab Chip. 9: 917-24, 2009. [Journal]
24)  Dawsey SP, Roth MJ, Adams L, Hu N, Wang QH, Taylor PR, Woodson K.
COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia.
Cancer Detect. Prev. 32: 135-9, 2008. [Journal]
25)  Adams L, Roth MJ, Abnet CC, Dawsey SP, Qiao Y, Wang G, Wei W, Lu N, Dawsey SM, Woodson K.
Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma.
Cancer Prev Res (Phila). 1: 357-61, 2008. [Journal]
26)  Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F.
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
J. Clin. Invest. 118: 640-50, 2008. [Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 5/13/2013.