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Our Science – Edelman Website

Daniel C. Edelman, Ph.D.

Selected Publications

1)  Petrini I, Meltzer PS, Kim IK, Lucchi M, Park KS, Fontanini G, Gao J, Zucali PA, Calabrese F, Favaretto A, Rea F, Rodriguez-Canales J, Walker RL, Pineda M, Zhu YJ, Lau C, Killian KJ, Bilke S, Voeller D, Dakshanamurthy S, Wang Y, Giaccone G.
A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.
Nat. Genet. 46: 844-9, 2014.
2)  Ellis RJ, Wang Y, Stevenson HS, Boufraqech M, Patel D, Nilubol N, Davis S, Edelman DC, Merino MJ, He M, Zhang L, Meltzer PS, Kebebew E.
Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype.
J. Clin. Endocrinol. Metab. 99: E329-37, 2014.
3)  Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS.
High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.
Nat. Genet. 46: 8-10, 2014.
4)  Howard B, Wang Y, Xekouki P, Faucz FR, Jain M, Zhang L, Meltzer PG, Stratakis CA, Kebebew E.
Integrated analysis of genome-wide methylation and gene expression shows epigenetic regulation of CYP11B2 in aldosteronomas.
J. Clin. Endocrinol. Metab. 99: E536-43, 2014.
5)  Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
J. Clin. Invest. 124: 398-412, 2014.
6)  Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K.
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
Oncogene. 32: 2726-38, 2013.
7)  Di LJ, Byun JS, Wong MM, Wakano C, Taylor T, Bilke S, Baek S, Hunter K, Yang H, Lee M, Zvosec C, Khramtsova G, Cheng F, Perou CM, Miller CR, Raab R, Olopade OI, Gardner K.
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.
Nat Commun. 4: 1449, 2013.
8)  Miettinen M, Killian JK, Wang ZF, Lasota J, Lau C, Jones L, Walker R, Pineda M, Zhu YJ, Kim SY, Helman L, Meltzer P.
Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.
Am. J. Surg. Pathol. 37: 234-40, 2013.
9)  Teer JK, Johnston JJ, Anzick SL, Pineda M, Stone G, Meltzer PS, Mullikin JC, Biesecker LG.
Massively-parallel sequencing of genes on a single chromosome: a comparison of solution hybrid selection and flow sorting.
BMC Genomics. 14: 253, 2013.
10)  Aung PP, Killian K, Poropatich CO, Linehan WM, Merino MJ.
Primary neuroendocrine tumors of the kidney: morphological and molecular alterations of an uncommon malignancy.
Hum. Pathol. 44: 873-80, 2013.
11)  Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology.
Cancer Res. 73: 4372-82, 2013.
12)  Azad N, Yu M, Davidson B, Choyke P, Chen CC, Wood BJ, Venkatesan A, Henning R, Calvo K, Minasian L, Edelman DC, Meltzer P, Steinberg SM, Annunziata CM, Kohn EC.
Translational predictive biomarker analysis of the phase 1b sorafenib and bevacizumab study expansion cohort.
Mol. Cell Proteomics. [Epub ahead of print], 2013.
13)  Bilke S, Gindin Y.
Analyzing the association of SCNA boundaries with replication timing.
Nat. Biotechnol. 30: 1043-5; author reply 1045-6, 2012.
14)  Petrini I, Meltzer PS, Zucali PA, Luo J, Lee C, Santoro A, Lee HS, Killian KJ, Wang Y, Tsokos M, Roncalli M, Steinberg SM, Wang Y, Giaccone G.
Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors.
Cell Death Dis. 3: e351, 2012.
15)  Rechache NS, Wang Y, Stevenson HS, Killian JK, Edelman DC, Merino M, Zhang L, Nilubol N, Stratakis CA, Meltzer PS, Kebebew E.
DNA Methylation Profiling Identifies Global Methylation Differences and Markers of Adrenocortical Tumors.
J Clin Endocrinol Metab. 97: E1004-13, 2012.
16)  Beachy SH, Onozawa M, Chung YJ, Slape C, Bilke S, Francis P, Pineda M, Walker RL, Meltzer P, Aplan PD.
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma.
Blood. 120: 1048-59, 2012.
17)  Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS.
Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples.
Methods Mol. Biol. 823: 107-18, 2012.
18)  Warren KE, Killian K, Suuriniemi M, Wang Y, Quezado M, Meltzer PS.
Genomic aberrations in pediatric diffuse intrinsic pontine gliomas.
Neuro Oncology. 14: 326-32, 2012.
19)  Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, Lai C, Belova G, Cam M, Walling J, Zhou M, Stevenson H, Kim HS, Killian K, Veenstra T, Bailey R, Song H, Zhang W, Fine HA.
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
PLoS ONE. 7: e51407, 2012.
20)  Gao Y, Killian K, Zhang H, Yu K, Li QZ, Weinstein S, Virtamo J, Tucker M, Taylor P, Albanes D, Meltzer P, Caporaso N.
Leukocyte DNA methylation and colorectal cancer among male smokers.
World J Gastrointest Oncol. 4: 193-201, 2012.
21)  Nader N, Ng SS, Wang Y, Abel BS, Chrousos GP, Kino T.
Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.
PLoS ONE. 7: e26751, 2012.
22)  Lee JH, Giovannetti E, Hwang JH, Petrini I, Wang Q, Voortman J, Wang Y, Steinberg SM, Funel N, Meltzer PS, Wang Y, Giaccone G.
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Clin. Cancer Res. 18: 524-33, 2012.
23)  Killian JK, Bilke S, Davis S, Walker RL, Jaeger E, Killian MS, Waterfall JJ, Bibikova M, Fan JB, Smith WI, Meltzer PS.
A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology.
Am. J. Pathol. 179: 55-65, 2011.
24)  Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome Res. 21: 1822-32, 2011.
25)  Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D.
Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
Clin. Exp. Metastasis. 28: 899-908, 2011.
26)  Eberle FC, Rodriguez-Canales J, Wei L, Hanson JC, Killian JK, Sun HW, Adams LG, Hewitt SM, Wilson WH, Pittaluga S, Meltzer PS, Staudt LM, Emmert-Buck MR, Jaffe ES.
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.
Haematologica. 96: 558-66, 2011.
27)  Valenzuela MS, Chen Y, Davis S, Yang F, Walker RL, Bilke S, Lueders J, Martin MM, Aladjem MI, Massion PP, Meltzer PS.
Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences.
PLoS ONE. 6: e17308, 2011.
28)  Nader N, Ng SS, Lambrou GI, Pervanidou P, Wang Y, Chrousos GP, Kino T.
AMPK Regulates Metabolic Actions of Glucocorticoids by Phosphorylating the Glucocorticoid Receptor through p38 MAPK.
Mol. Endocrinol. 24: 1748-64, 2010.
29)  Killian JK, Walker RL, Suuriniemi M, Jones L, Scurci S, Singh P, Cornelison R, Harmon S, Boisvert N, Zhu J, Wang Y, Bilke S, Davis S, Giaccone G, Smith WI, Meltzer PS.
Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling.
J Mol Diagn. 12: 739-45, 2010.
30)  Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI, Meltzer P, Wang Y, Giaccone G.
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proc. Natl. Acad. Sci. U.S.A. 107: 13040-5, 2010.
31)  Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, Rao M, Meltzer PA, Schrump DS.
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.
Oncogene. 29: 3650-64, 2010.
32)  Cao L, Yu Y, Bilke S, Walker RL, Mayeenuddin LH, Azorsa DO, Yang F, Pineda M, Helman LJ, Meltzer PS.
Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.
Cancer Res. 70: 6497-508, 2010.
33)  Eberle FC, Hanson JC, Killian JK, Wei L, Ylaya K, Hewitt SM, Jaffe ES, Emmert-Buck MR, Rodriguez-Canales J.
Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens.
J Mol Diagn. 12: 394-401, 2010.
34)  Killian JK.
Large-scale molecular profiling of the cancer tissue methylome. In: Methods in Molecular Biology: Individualized Molecular Medicine.
Humana Press; 2009. In Press. [Book Chapter]
35)  Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH.
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Sci Signal. 2: ra5, 2009.
36)  Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Proc. Natl. Acad. Sci. U.S.A. 106: 19286-91, 2009.
37)  Kino T, Manoli I, Kelkar S, Wang Y, Su YA, Chrousos GP.
Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity.
Biochem. Biophys. Res. Commun. 381: 671-5, 2009.
38)  Killian JK, Bilke S, Davis S, Walker RL, Killian MS, Jaeger EB, Chen Y, Hipp J, Pittaluga S, Raffeld M, Cornelison R, Smith WI, Bibikova M, Fan JB, Emmert-Buck MR, Jaffe ES, Meltzer PS.
Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome.
Cancer Res. 69: 758-64, 2009.
39)  Kralj JG, Player A, Sedrick H, Munson MS, Petersen D, Forry SP, Meltzer P, Kawasaki E, Locascio LE.
T7-based linear amplification of low concentration mRNA samples using beads and microfluidics for global gene expression measurements.
Lab Chip. 9: 917-24, 2009.
40)  Chen QR, Song YK, Wei JS, Bilke S, Asgharzadeh S, Seeger RC, Khan J.
An integrated cross-platform prognosis study on neuroblastoma patients.
Genomics. 92: 195-203, 2008.
41)  Dawsey SP, Roth MJ, Adams L, Hu N, Wang QH, Taylor PR, Woodson K.
COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia.
Cancer Detect. Prev. 32: 135-9, 2008.
42)  Adams L, Roth MJ, Abnet CC, Dawsey SP, Qiao Y, Wang G, Wei W, Lu N, Dawsey SM, Woodson K.
Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma.
Cancer Prev Res (Phila). 1: 357-61, 2008.
43)  Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martínez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F.
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
J. Clin. Invest. 118: 640-50, 2008.
44)  Tongbai R, Idelman G, Nordgard SH, Cui W, Jacobs JL, Haggerty CM, Chanock SJ, Børresen-Dale AL, Livingston G, Shaunessy P, Chiang CH, Kristensen VN, Bilke S, Gardner K.
Transcriptional networks inferred from molecular signatures of breast cancer.
Am. J. Pathol. 172: 495-509, 2008.
45)  Bilke S, Chen QR, Wei JS, Khan J.
Whole chromosome alterations predict survival in high-risk neuroblastoma without MYCN amplification.
Clin. Cancer Res. 14: 5540-7, 2008.
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This page was last updated on 7/30/2014.