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Our Science – Trinchieri Website

Giorgio Trinchieri, M.D.

Selected Publications

1)  Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher A.
Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.
J. Immunol. 190: 5722-30, 2013.
[Journal]
2)  Ascierto PA, Grimaldi AM, Acquavella N, Borgognoni L, Calabrò L, Cascinelli N, Cesano A, Del Vecchio M, Eggermont AM, Faries M, Ferrone S, Fox BA, Gajewski TF, Galon J, Gnjatic S, Gogas H, Kashani-Sabet M, Kaufman HL, Larkin J, Lo RS, Mantovani A, Margolin K, Melief C, McArthur G, Palmieri G, Puzanov I, Ribas A, Seliger B, Sosman J, Suenaert P, Tarhini AA, Trinchieri G, Vidal-Vanaclocha F, Wang E, Ciliberto G, Mozzillo N, Marincola FM, Thurin M.
Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".
J Transl Med. 11: 137, 2013.
[Journal]
3)  Stewart CA, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, Leighty RM, Roers A, Karp CL, Müller W, Trinchieri G.
Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation.
J. Clin. Invest. 2013.
[Journal]
4)  Molloy MJ, Grainger JR, Bouladoux N, Hand TW, Koo LY, Naik S, Quinones M, Dzutsev AK, Gao JL, Trinchieri G, Murphy PM, Belkaid Y.
Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis.
Cell Host Microbe. 14: 318-28, 2013.
[Journal]
5)  Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-? production by repressing ß-catenin activation in dendritic cells.
PLoS Pathog. 9: e1003357, 2013.
[Journal]
6)  Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA.
Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.
Clin. Cancer Res. 19: 1340-6, 2013.
[Journal]
7)  Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G.
MyD88 and its divergent toll in carcinogenesis.
Trends Immunol. 34: 379-89, 2013.
[Journal]
8)  Pang Y, Gara SK, Achyut BR, Li Z, Yan HH, Day CP, Weiss JM, Trinchieri G, Morris JC, Yang L.
TGF-ß signaling in myeloid cells is required for tumor metastasis.
Cancer Discov. 3: 936-51, 2013.
[Journal]
9)  Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M.
The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter.
J. Exp. Med. 210: 1369-87, 2013.
[Journal]
10)  Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
The pivotal role of IKKa in the development of spontaneous lung squamous cell carcinomas.
Cancer Cell. 23: 527-40, 2013.
[Journal]
11)  Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Nature. 491: 254-8, 2012.
[Journal]
12)  Trinchieri G.
Cancer and inflammation: an old intuition with rapidly evolving new concepts.
Annu. Rev. Immunol. 30: 677-706, 2012.
[Journal]
13)  Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Arndt H, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O'Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D'Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA.
Cancer classification using the Immunoscore: a worldwide task force.
J Transl Med. 10: 205, 2012.
[Journal]
14)  Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y.
Compartmentalized control of skin immunity by resident commensals.
Science. 337: 1115-9, 2012.
[Journal]
15)  Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.
J. Exp. Med. 209: 1689-702, 2012.
[Journal]
16)  Berezhnoy A, Stewart CA, McNamara Ii JO, Thiel W, Giangrande P, Trinchieri G, Gilboa E.
Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing.
Molecular therapy : the journal of the American Society of Gene Therapy. 2012.
[Journal]
17)  Trinchieri G.
Lymphocyte choriomeningitis virus plays hide-and-seek with type 1 interferon.
Cell Host Microbe. 11: 553-5, 2012.
[Journal]
18)  Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A.
NK cell-derived interferon-? orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.
Immunity. 36: 1047-59, 2012.
[Journal]
19)  Galon J, Pagès F, Marincola FM, Thurin M, Trinchieri G, Fox BA, Gajewski TF, Ascierto PA.
The immune score as a new possible approach for the classification of cancer.
J Transl Med. 10: 1, 2012.
[Journal]
20)  Goldszmid RS, Trinchieri G.
The price of immunity.
Nat. Immunol. 13: 932-8, 2012.
[Journal]
21)  Wu J, Li J, Salcedo R, Mivechi NF, Trinchieri G, Horuzsko A.
The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma.
Cancer Res. 72: 3977-86, 2012.
[Journal]
22)  Sisirak V, Vey N, Vanbervliet B, Duhen T, Puisieux I, Homey B, Bowman EP, Trinchieri G, Dubois B, Kaiserlian D, Lira SA, Puisieux A, Blay JY, Caux C, Bendriss-Vermare N.
CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues.
Blood. 118: 5130-40, 2011.
[Journal]
23)  Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A.
Highlights of 10 years of immunology in Nature Reviews Immunology.
Nat. Rev. Immunol. 11: 693-702, 2011.
[Journal]
24)  Stewart CA, Trinchieri G.
At 17, In-10's Passion Need Not Inflame.
Immunity. 34: 460-2, 2011.
[Journal]
25)  Saleh M, Trinchieri G.
Innate immune mechanisms of colitis and colitis-associated colorectal cancer.
Nat. Rev. Immunol. 11: 9-20, 2011.
[Journal]
26)  Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G.
Interferon-γ links ultraviolet radiation to melanomagenesis in mice.
Nature. 469: 548-53, 2011.
[Journal]
27)  Lau-Kilby AW, Kretz CC, Pechhold S, Price JD, Dorta S, Ramos H, Trinchieri G, Tarbell KV.
Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 108: 2408-13, 2011.
[Journal]
28)  Butterfield LH, Palucka AK, Britten CM, Dhodapkar MV, Håkansson L, Janetzki S, Kawakami Y, Kleen TO, Lee PP, Maccalli C, Maecker HT, Maino VC, Maio M, Malyguine A, Masucci G, Pawelec G, Potter DM, Rivoltini L, Salazar LG, Schendel DJ, Slingluff CL, Song W, Stroncek DF, Tahara H, Thurin M, Trinchieri G, van Der Burg SH, Whiteside TL, Wigginton JM, Marincola F, Khleif S, Fox BA, Disis ML.
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research. 17: 3064-3076, 2011.
[Journal]
29)  Kerkar SP, Goldszmid RS, Muranski P, Chinnasamy D, Yu Z, Reger RN, Leonardi AJ, Morgan RA, Wang E, Marincola FM, Trinchieri G, Rosenberg SA, Restifo NP.
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
J. Clin. Invest. 121: 4746-57, 2011.
[Journal]
30)  Trinchieri G.
Inflammation in cancer: a therapeutic target?.
Oncology (Williston Park, N.Y.). 25: 418-20, 2011.
[Journal]
31)  Trinchieri G.
Innate inflammation and cancer: Is it time for cancer prevention?.
F1000 Med Rep. 3: 11, 2011.
[Journal]
32)  Novikov A, Cardone M, Thompson R, Shenderov K, Kirschman KD, Mayer-Barber KD, Myers TG, Rabin RL, Trinchieri G, Sher A, Feng CG.
Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages.
J. Immunol. 187: 2540-7, 2011.
[Journal]
33)  Reizis B, Colonna M, Trinchieri G, Barrat F, Gilliet M.
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?.
Nat. Rev. Immunol. 11: 558-65, 2011.
[Journal]
34)  Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT.
Cancer and inflammation: promise for biologic therapy.
J. Immunother. 33: 335-51, 2010.
[Journal]
35)  Garg H, Salcedo R, Trinchieri G, Blumenthal R.
Improved nonviral cancer suicide gene therapy using survivin promoter-driven mutant Bax.
Cancer Gene Ther. 17: 155-63, 2010.
[Journal]
36)  Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
J. Exp. Med. 207: 1625-36, 2010.
[Journal]
37)  Nussenblatt RB, Bielekova B, Childs R, Krensky A, Strober W, Trinchieri G.
National Institutes of Health Center for Human Immunology Conference, September 2009.
Ann. N. Y. Acad. Sci. 1200 Suppl 1: E1-23, 2010.
[Journal]
38)  Sangaletti S, Tripodo C, Ratti C, Piconese S, Porcasi R, Salcedo R, Trinchieri G, Colombo MP, Chiodoni C.
Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis.
Cancer Res. 70: 7764-75, 2010.
[Journal]
39)  Perrot I, Deauvieau F, Massacrier C, Hughes N, Garrone P, Durand I, Demaria O, Viaud N, Gauthier L, Blery M, Bonnefoy-Berard N, Morel Y, Tschopp J, Alexopoulou L, Trinchieri G, Paturel C, Caux C.
TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA.
J. Immunol. 185: 2080-8, 2010.
[Journal]
40)  Kerkar SP, Muranski P, Kaiser A, Boni A, Sanchez-Perez L, Yu Z, Palmer DC, Reger RN, Borman ZA, Zhang L, Morgan RA, Gattinoni L, Rosenberg SA, Trinchieri G, Restifo NP.
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
Cancer Res. 70: 6725-34, 2010.
[Journal]
41)  Trinchieri G.
Type I interferon: friend or foe?.
J. Exp. Med. 207: 2053-63, 2010.
[Journal]
42)  McVicar DW, Trinchieri G.
CSF-1R, DAP12 and beta-catenin: a ménage à trois.
Nat. Immunol. 10: 681-3, 2009.
[Journal]
43)  Goldszmid RS, Hasan UA, Trinchieri G.
Double stranded RNA tricks melanoma cells into committing suicide.
Pigment Cell Melanoma Res. 22: 705-6, 2009.
[Journal]
44)  Salcedo R, Hixon JA, Stauffer JK, Jalah R, Brooks AD, Khan T, Dai RM, Scheetz L, Lincoln E, Back TC, Powell D, Hurwitz AA, Sayers TJ, Kastelein R, Pavlakis GN, Felber BK, Trinchieri G, Wigginton JM.
Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver and bone marrow.
J. Immunol. 182: 4328-38, 2009.
[Journal]
45)  Gordon S, Trinchieri G.
Innate resistance and inflammation.
Curr. Opin. Immunol. 21: 1-2, 2009.
[Journal]
46)  Stewart CA, Trinchieri G.
Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression.
Cancer Cell. 15: 81-3, 2009.
[Journal]
47)  Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Thurin M, Trinchieri G, Wang E, Wigginton J, Chaussabel D, Coukos G, Dhodapkar M, Håkansson L, Janetzki S, Kleen TO, Kirkwood JM, Maccalli C, Maecker H, Maio M, Malyguine A, Masucci G, Palucka AK, Potter DM, Ribas A, Rivoltini L, Schendel D, Seliger B, Selvan S, Slingluff CL, Stroncek DF, Streicher H, Wu X, Zeskind B, Zhao Y, Zocca MB, Zwierzina H, Marincola FM.
A systematic approach to biomarker discovery; preamble to.
J Transl Med. 6: 81, 2008.
[Journal]
48)  Gerosa F, Baldani-Guerra B, Lyakh LA, Batoni G, Esin S, Winkler-Pickett RT, Consolaro MR, De Marchi M, Giachino D, Robbiano A, Astegiano M, Sambataro A, Kastelein RA, Carra G, Trinchieri G.
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells.
J. Exp. Med. 205: 1447-61, 2008.
[Journal]
49)  Goubier A, Dubois B, Gheit H, Joubert G, Villard-Truc F, Asselin-Paturel C, Trinchieri G, Kaiserlian D.
Plasmacytoid dendritic cells mediate oral tolerance.
Immunity. 29: 464-75, 2008.
[Journal]
50)  Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F.
Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans.
Immunol. Rev. 226: 112-31, 2008.
[Journal]
51)  Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J.
Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.
Proc Natl Acad Sci U S A. 2007.
[Journal]
52)  Trinchieri G, Sher A.
Cooperation of Toll-like receptor signals in innate immune defence.
Nat. Rev. Immunol. 7: 179-90, 2007.
[Journal]
53)  Jankovic D, Trinchieri G.
IL-10 or not IL-10: that is the question.
Nat. Immunol. 8: 1281-3, 2007.
[Journal]
54)  Trinchieri G.
Interleukin-10 production by effector T cells: Th1 cells show self control.
J. Exp. Med. 204: 239-43, 2007.
[Journal]
55)  Trinchieri G.
Pillars of immunology: The birth of a cell type.
J. Immunol. 178: 3-4, 2007.
[Journal]
56)  Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A.
TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.
J. Exp. Med. 204: 2591-602, 2007.
[Journal]
57)  Ochando JC, Homma C, Yang Y, Hidalgo A, Garin A, Tacke F, Angeli V, Li Y, Boros P, Ding Y, Jessberger R, Trinchieri G, Lira SA, Randolph GJ, Bromberg JS.
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.
Nat. Immunol. 7: 652-62, 2006.
[Journal]
58)  Zitvogel L, Terme M, Borg C, Trinchieri G.
Dendritic cell-NK cell cross-talk: regulation and physiopathology.
Curr. Top. Microbiol. Immunol. 298: 157-74, 2006.
[Journal]
59)  Allman D, Dalod M, Asselin-Paturel C, Delale T, Robbins SH, Trinchieri G, Biron CA, Kastner P, Chan S.
Ikaros is required for plasmacytoid dendritic cell differentiation.
Blood. 108: 4025-34, 2006.
[Journal]
60)  Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE.
Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.
J. Immunol. 176: 3149-56, 2006.
[Journal]
61)  Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin-Paturel C, Pereira JP, Bates EE, Akira S, Vieira P, Liu YJ, Trinchieri G, O'Garra A.
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
J. Immunol. 177: 7551-8, 2006.
[Journal]
62)  Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P.
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.
J. Exp. Med. 201: 1435-46, 2005.
[Journal]
63)  Merck E, de Saint-Vis B, Scuiller M, Gaillard C, Caux C, Trinchieri G, Bates EE.
Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.
Blood. 105: 3623-32, 2005.
[Journal]
64)  Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, Guiet C, Brière F, Vlach J, Lebecque S, Trinchieri G, Bates EE.
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.
J. Immunol. 174: 2942-50, 2005.
[Journal]
65)  Fallarino F, Orabona C, Vacca C, Bianchi R, Gizzi S, Asselin-Paturel C, Fioretti MC, Trinchieri G, Grohmann U, Puccetti P.
Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.
Int. Immunol. 17: 1429-38, 2005.
[Journal]
66)  Delale T, Paquin A, Asselin-Paturel C, Dalod M, Brizard G, Bates EE, Kastner P, Chan S, Akira S, Vicari A, Biron CA, Trinchieri G, Brière F.
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
J. Immunol. 175: 6723-32, 2005.
[Journal]
67)  Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP.
Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.
Cancer Res. 65: 3437-46, 2005.
[Journal]
68)  Gerosa F, Gobbi A, Zorzi P, Burg S, Briere F, Carra G, Trinchieri G.
The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions.
J. Immunol. 174: 727-34, 2005.
[Journal]
69)  Hasan UA, Trinchieri G, Vlach J.
Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts.
J. Biol. Chem. 280: 20620-7, 2005.
[Journal]
70)  Asselin-Paturel C, Brizard G, Chemin K, Boonstra A, O'Garra A, Vicari A, Trinchieri G.
Type I interferon dependence of plasmacytoid dendritic cell activation and migration.
J. Exp. Med. 201: 1157-67, 2005.
[Journal]
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This page was last updated on 11/14/2013.