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Our Science – Klinman Website

Dennis M. Klinman, M.D., Ph.D.

Selected Publications

1)  Klinman DM, Higgins KW, Conover J.
Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells.
J. Exp. Med. 173: 881-7, 1991.
2)  Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM.
CpG motifs in bacterial DNA trigger direct B-cell activation.
Nature. 374: 546-9, 1995.
3)  Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM.
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
Proc. Natl. Acad. Sci. U.S.A. 93: 2879-83, 1996.
4)  Verthelyi D, Ishii KJ, Gursel M, Takeshita F, Klinman DM.
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.
J. Immunol. 166: 2372-7, 2001.
5)  Shirota Y, Shirota H, Klinman DM.
Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells.
J. Immunol. 188: 1592-9, 2012.
6)  Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
J. Autoimmun. [Epub ahead of print], 2014.
7)  Shirota H, Klinman DM.
Recent progress concerning CpG DNA and its use as a vaccine adjuvant.
Expert Rev Vaccines. 13: 299-312, 2014.
8)  Bode C, Kinjo T, Alvord WG, Klinman DM.
Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.
Carcinogenesis. 35: 1078-83, 2014.
9)  Shirota H, Klinman DM.
TLR-9 agonist immunostimulatory sequence adjuvants linked to cancer antigens.
Methods Mol. Biol. 1139: 337-44, 2014.
10)  Shi G, Vistica BP, Nugent LF, Tan C, Wawrousek EF, Klinman DM, Gery I.
Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands.
J. Immunol. 191: 415-23, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 6/20/2014.