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Our Science – Redon Website

Christophe E. Redon, Ph.D.

Selected Publications

1)  Redon CR, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF, Bonner WM.
Christensen D, Sugarman S, O'Hara FM, eds.
A Study in Nonhuman Primates for Total- and Partial-Body Irradiation. In: The Medical Basis for Radiation-Accident Preparedness.
New York: Parthenon; 2013. p. 391-396 [Book Chapter]
2)  Moroni M, Maeda D, Whitnall MH, Bonner WM, Redon CE.
Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model.
Int J Mol Sci. 14: 14119-35, 2013.
[Journal]
3)  Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA.
Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.
PLoS ONE. 8: e70575, 2013.
[Journal]
4)  Weyemi U, Redon CE, Parekh PR, Dupuy C, Bonner WM.
NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy.
Anticancer Agents Med Chem. 13: 502-14, 2013.
[Journal]
5)  Sprung CN, Ivashkevich A, Forrester HB, Redon CE, Georgakilas A, Martin OA.
Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.
Cancer Lett. 2013.
[Journal]
6)  Nakamura AJ, Parekh P, Martin OA, Bonner WM, Redon CR.
Gamma-H2AX Formation and Chromatin Structure. In: Advances in Genetics Research. Volume 7.
Hauppage, NY: Nova Sciences Publisher; 2012. p. 127-152 [Book Chapter]
7)  Redon CE, Weyemi U, Parekh PR, Huang D, Burrell AS, Bonner WM.
?-H2AX and other histone post-translational modifications in the clinic.
Biochim. Biophys. Acta. 1819: 743-56, 2012.
[Journal]
8)  Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon CE, Zhang H, Neckers L, Pommier Y.
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
PLoS ONE. 7: e41094, 2012.
[Journal]
9)  Weyemi U, Parekh PR, Redon CE, Bonner WM.
SOD2 deficiency promotes aging phenotypes in mouse skin.
Aging (Albany NY). 4: 116-8, 2012.
[Journal]
10)  Dickey JS, Baird BJ, Redon CE, Avdoshina V, Palchik G, Wu J, Kondratyev A, Bonner WM, Martin OA.
Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.
Nucleic Acids Res. 40: 10274-86, 2012.
[Journal]
11)  Ivashkevich A, Redon CE, Nakamura AJ, Martin RF, Martin OA.
Use of the ?-H2AX assay to monitor DNA damage and repair in translational cancer research.
Cancer Lett. 327: 123-33, 2012.
[Journal]
12)  Dickey JS, Redon CE, Nakamura A, Baird BJ, Sedelnikova OA, Bonner WM.
Stress and gamma-H2AX. In: Handbook of Cell Signaling, In Regulation of organelle and Cell compartment Signalling. Section B, nuclear signalling - Part 3 Stress Responses.
San Diego, CA: AP Press; 2011. p. 309-319 [Book Chapter]
13)  Redon CE, Dickey JS, Nakamura AJ, Martin OA, Bonner WM.
DeWeese TL, Laiho M, eds.
H2AX in DNA damage. In: Molecular Determinants of Radiation Response.
Baltimore, MD: Springer Sciences; 2011. p. 3-33 [Book Chapter]
14)  Redon CE, Bonner WM.
High salt and DNA double-strand breaks.
Proc. Natl. Acad. Sci. U.S.A. 108: 20281-2, 2011.
[Journal]
15)  Baird BJ, Dickey JS, Nakamura AJ, Redon CE, Parekh P, Griko YV, Aziz K, Georgakilas AG, Bonner WM, Martin OA.
Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing.
Mutat. Res. 711: 142-9, 2011.
[Journal]
16)  Redon CE, Nakamura AJ, Sordet O, Dickey JS, Gouliaeva K, Tabb B, Lawrence S, Kinders RJ, Bonner WM, Sedelnikova OA.
γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.
Methods Mol. Biol. 682: 249-70, 2011.
[Journal]
17)  Ivashkevich AN, Martin OA, Smith AJ, Redon CE, Bonner WM, Martin RF, Lobachevsky PN.
γH2AX foci as a measure of DNA damage: A computational approach to automatic analysis.
Mutat. Res. 711: 49-60, 2011.
[Journal]
18)  Martin OA, Redon CE, Dickey JS, Nakamura AJ, Bonner WM.
Para-inflammation mediates systemic DNA damage in response to tumor growth.
Commun Integr Biol. 4: 78-81, 2011.
[Journal]
19)  Redon CE, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF, Bonner WM.
Q(?-H2AX), an analysis method for partial-body radiation exposure using ?-H2AX in nonhuman primate lymphocytes.
Radiat Meas. 46: 877-881, 2011.
[Journal]
20)  Redon CE, Nakamura AJ, Martin OA, Parekh PR, Weyemi US, Bonner WM.
Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker.
Aging (Albany NY). 3: 168-74, 2011.
[Journal]
21)  Martin OA, Redon CE, Nakamura AJ, Dickey JS, Georgakilas AG, Bonner WM.
Systemic DNA damage related to cancer.
Cancer Res. 71: 3437-41, 2011.
[Journal]
22)  Sordet O, Nakamura AJ, Redon CE, Pommier Y.
DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions.
Cell Cycle. 9: 274-8, 2010.
[Journal]
23)  Redon CE, Nakamura AJ, Zhang YW, Ji JJ, Bonner WM, Kinders RJ, Parchment RE, Doroshow JH, Pommier Y.
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.
Clin. Cancer Res. 16: 4532-42, 2010.
[Journal]
24)  Nakamura AJ, Redon CE, Bonner WM.
γH2AX: Applications for the evaluation of telomerase-based cancer therapy.
Cell Cycle. 9: 3385-6, 2010.
[Journal]
25)  Redon CE, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF, Bonner WM.
The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates.
PLoS ONE. 5: e15544, 2010.
[Journal]
26)  Redon CE, Dickey JS, Nakamura AJ, Kareva IG, Naf D, Nowsheen S, Kryston TB, Bonner WM, Georgakilas AG, Sedelnikova OA.
Tumors induce complex DNA damage in distant proliferative tissues in vivo.
Proc. Natl. Acad. Sci. U.S.A. 107: 17992-7, 2010.
[Journal]
27)  Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
EMBO Rep. 10: 887-93, 2009.
[Journal]
28)  Redon CE, Dickey JS, Bonner WM, Sedelnikova OA.
gamma-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin.
Adv Space Res. 43: 1171-1178, 2009.
[Journal]
29)  Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM.
H2AX: functional roles and potential applications.
Chromosoma. 118: 683-92, 2009.
[Journal]
30)  Dickey JS, Baird BJ, Redon CE, Sokolov MV, Sedelnikova OA, Bonner WM.
Intercellular communication of cellular stress monitored by gamma-H2AX induction.
Carcinogenesis. 30: 1686-95, 2009.
[Journal]
31)  Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
EMBO J. 28: 3667-80, 2009.
[Journal]
32)  Sedelnikova OA, Redon CE, Dickey JS, Nakamura AJ, Georgakilas AG, Bonner WM.
Role of oxidatively induced DNA lesions in human pathogenesis.
Mutat. Res. 704: 152-9, 2009.
[Journal]
33)  Nakamura AJ, Redon CE, Bonner WM, Sedelnikova OA.
Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells.
Aging (Albany NY). 1: 212-8, 2009.
[Journal]
34)  Nakamura AJ, Redon CE, Sedelnikova OA.
Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells.
Cell Cycle. 8: 2324, 2009.
[Journal]
35)  Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM.
Delayed kinetics of DNA double-strand break processing in normal and pathological aging.
Aging Cell. 7: 89-100, 2008.
[Journal]
36)  Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y.
GammaH2AX and cancer.
Nat. Rev. Cancer. 8: 957-67, 2008.
[Journal]
37)  Sordet O, Goldman A, Redon C, Solier S, Rao VA, Pommier Y.
Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.
J. Biol. Chem. 283: 23200-8, 2008.
[Journal]
38)  Guirouilh-Barbat J, Redon C, Pommier Y.
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Mol. Biol. Cell. 19: 3969-81, 2008.
[Journal]
39)  Sonoda E, Zhao GY, Kohzaki M, Dhar PK, Kikuchi K, Redon C, Pilch DR, Bonner WM, Nakano A, Watanabe M, Nakayama T, Takeda S, Takami Y.
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.
DNA Repair (Amst.). 6: 280-92, 2007.
[Journal]
40)  Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y.
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
Mol. Cancer Ther. 6: 3229-38, 2007.
[Journal]
41)  Redon C, Pilch DR, Bonner WM.
Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.
Genetics. 172: 67-76, 2006.
[Journal]
42)  Pommier Y, Barcelo JM, Rao VA, Sordet O, Jobson AG, Thibaut L, Miao ZH, Seiler JA, Zhang H, Marchand C, Agama K, Nitiss JL, Redon C.
Repair of topoisomerase I-mediated DNA damage.
Prog. Nucleic Acid Res. Mol. Biol. 81: 179-229, 2006.
[Journal]
43)  Nakamura A, Sedelnikova OA, Redon C, Pilch DR, Sinogeeva NI, Shroff R, Lichten M, Bonner WM.
Techniques for gamma-H2AX detection.
Meth. Enzymol. 409: 236-50, 2006.
[Journal]
44)  Nakamura TM, Du LL, Redon C, Russell P.
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.
Mol. Cell. Biol. 24: 6215-30, 2004.
[Journal]
45)  Pilch DR, Redon C, Sedelnikova OA, Bonner WM.
Two-dimensional gel analysis of histones and other H2AX-related methods.
Meth. Enzymol. 375: 76-88, 2004.
[Journal]
46)  Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM.
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.
Biochem. Cell Biol. 81: 123-9, 2003.
[Journal]
47)  Sedelnikova OA, Pilch DR, Redon C, Bonner WM.
Histone H2AX in DNA damage and repair.
Cancer Biol. Ther. 2: 233-5, 2003.
[Journal]
48)  Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
J. Biol. Chem. 278: 20303-12, 2003.
[Journal]
49)  Pommier Y, Redon C, Rao VA, Seiler JA, Sordet O, Takemura H, Antony S, Meng L, Liao Z, Kohlhagen G, Zhang H, Kohn KW.
Repair of and checkpoint response to topoisomerase I-mediated DNA damage.
Mutat. Res. 532: 173-203, 2003.
[Journal]
50)  Redon C, Pilch DR, Rogakou EP, Orr AH, Lowndes NF, Bonner WM.
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.
EMBO Rep. 4: 678-84, 2003.
[Journal]
51)  Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.
Genomic instability in mice lacking histone H2AX.
Science. 296: 922-7, 2002.
[Journal]
52)  Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W.
Histone H2A variants H2AX and H2AZ.
Curr. Opin. Genet. Dev. 12: 162-9, 2002.
[Journal]
53)  Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature. 414: 660-5, 2001.
[Journal]
54)  Rogakou EP, Redon C, Boon C, Johnson K, Bonner WM.
Rapid histone extraction for electrophoretic analysis.
BioTechniques. 28: 38-40, 42, 46, 2000.
[Journal]
55)  Rogakou EP, Boon C, Redon C, Bonner WM.
Megabase chromatin domains involved in DNA double-strand breaks in vivo.
J. Cell Biol. 146: 905-16, 1999.
[Journal]
56)  Albert P, Redon C.
Efficient antibody generation using histone H1 subfractions purified from western blots.
Anal. Biochem. 261: 87-92, 1998.
[Journal]
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This page was last updated on 11/25/2013.