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Our Science – Hughes Website

Stephen H. Hughes, Ph.D.

Selected Publications

1)  Abram M, Ferris A, Das K, Quinones O, Shao W, Tusk S, Alvord W, Arnold E, Hughes S.
Mutations in HIV-1 RT 1 affect the errors made in a single cycle of viral 2 replication.
J Virol. 2014.
In Press. [Journal]
2)  Zhao XZ, Smith SJ, Métifiot M, Johnson BC, Marchand C, Pommier Y, Hughes SH, Burke TR.
Bicyclic 1-Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV-1 Integrase Inhibitors Having High Antiviral Potency against Cells Harboring Raltegravir-Resistant Integrase Mutants.
J. Med. Chem. 57: 1573-82, 2014.
[Journal]
3)  De Ravin SS, Su L, Theobald N, Choi U, Macpherson JL, Poidinger M, Symonds G, Pond SM, Ferris AL, Hughes SH, Malech HL, Wu X.
Enhancers are major targets for murine leukemia virus vector integration.
J. Virol. 88: 4504-13, 2014.
[Journal]
4)  Varadarajan J, McWilliams MJ, Hughes SH.
Treatment with suboptimal doses of raltegravir leads to aberrant HIV-1 integrations.
Proc. Natl. Acad. Sci. U.S.A. 110: 14747-52, 2013.
[Journal]
5)  Dunn LL, Boyer PL, Clark PK, Hughes SH.
Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.
Virology. 444: 241-9, 2013.
[Journal]
6)  Johnson B, Metifiot M, Ferris A, Pommier Y, Hughes S.
A homology model of HIV-1 integrase and analysis of mutations designed to test the model.
J Mol Biol. 425: 2133-2146, 2013.
Full Text Article. [Journal]
7)  Lauberth SM, Nakayama T, Wu X, Ferris AL, Tang Z, Hughes SH, Roeder RG.
H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation.
Cell. 152: 1021-36, 2013.
[Journal]
8)  Johnson B, Pauly G, Rai G, Patel D, Bauman J, Baker H, Das K, Schneider J, Maloney D, Arnold E, Thomas C, Hughes S.
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Retrovirology. 9: 99, 2012.
Full Text Article. [Journal]
9)  De Ravin SS, Gray JT, Throm RE, Spindler J, Kearney M, Wu X, Coffin JM, Hughes SH, Malderelli F, Sorrentino BP, Malech HL.
False-Positive HIV PCR Test Following Ex Vivo Lentiviral Gene Transfer Treatment of X-linked Severe Combined Immunodeficiency Vector.
Mol. Ther. 22: 244-5, 2014.
[Journal]
10)  Ivetac A, Swift SE, Boyer PL, Diaz A, Naughton J, Young JA, Hughes SH, McCammon JA.
Discovery of Novel Inhibitors of HIV-1 Reverse Transcriptase Through Virtual Screening of Experimental and Theoretical Ensembles.
Chem Biol Drug Des. 2014.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/24/2014.