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Our Science – Lountos Website

George T. Lountos, Ph.D.

Selected Publications

1)  Liu F, Hakami RM, Dyas B, Bahta M, Lountos GT, Waugh DS, Ulrich RG, Burke TR.
A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.
Bioorg. Med. Chem. Lett. 20: 2813-6, 2010.
2)  Muus U, Hose C, Yao W, Kosakowska-Cholody T, Farnsworth D, Dyba M, Lountos GT, Waugh DS, Monks A, Burke TR, Michejda CJ.
Development of antiproliferative phenylmaleimides that activate the unfolded protein response.
Bioorg. Med. Chem. 18: 4535-41, 2010.
3)  Zhang H, Lountos GT, Ching CB, Jiang R.
Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol.
Appl. Microbiol. Biotechnol. 88: 117-24, 2010.
4)  Lountos GT, Austin BP, Nallamsetty S, Waugh DS.
Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion.
Protein Sci. 18: 467-74, 2009.
5)  Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Cerna D, Tropea JE, Onda A, Zoppoli G, Kondapaka S, Zhang G, Caplen NJ, Cardellina JH, Yoo SS, Monks A, Self C, Waugh DS, Shoemaker RH, Pommier Y.
Cellular inhibition of Chk2 kinase and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019.
J. Pharmacol. Exp. Ther. 2009.
6)  Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS.
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Protein Sci. 18: 92-100, 2009.
7)  Orville AM, Lountos GT, Finnegan S, Gadda G, Prabhakar R.
Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase.
Biochemistry. 48: 720-8, 2009.
8)  Lountos GT, Tropea JE, Cherry S, Waugh DS.
Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
Acta Crystallogr. D Biol. Crystallogr. 65: 1013-20, 2009.
9)  Quaye O, Lountos GT, Fan F, Orville AM, Gadda G.
Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase.
Biochemistry. 47: 243-56, 2008.
10)  Lountos GT, Jiang R, Wellborn WB, Thaler TL, Bommarius AS, Orville AM.
The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme.
Biochemistry. 45: 9648-59, 2006.
Click Here to View Expanded Bibliography.

This page was last updated on 2/5/2011.