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Our Science – Sung Website

Myong-Hee Sung, Ph.D.

Selected Publications

1)  Sung MH, Li N, Lao Q, Gottschalk RA, Hager GL, Fraser ID.
Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF-?B Signaling.
Sci Signal. 7: ra6, 2014.
2)  Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 155: 1507-20, 2013.
3)  Hakim O, Sung MH, Nakayamada S, Voss TC, Baek S, Hager GL.
Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.
Genome Res. 23: 462-72, 2013.
4)  Baek S, Sung MH, Hager GL.
Quantitative analysis of genome-wide chromatin remodeling.
Methods Mol. Biol. 833: 433-41, 2012.
5)  Sung MH, Salvatore L, De Lorenzi R, Indrawan A, Pasparakis M, Hager GL, Bianchi ME, Agresti A.
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles.
PLoS ONE. 4: e7163, 2009.
6)  Morris SA, Baek S, Sung MH, John S, Wiench M, Johnson TA, Schiltz RL, Hager GL.
Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions.
Nat. Struct. Mol. Biol. 21: 73-81, 2014.
7)  Sung M.
A Checklist for Successful Quantitative Live Cell Imaging in Systems Biology.
Cells. 2: 284-293, 2013.
Full Text Article. [Journal]
8)  Miranda TB, Voss TC, Sung MH, Baek S, John S, Hawkins M, Grøntved L, Schiltz RL, Hager GL.
Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level.
Cancer Res. 73: 5130-9, 2013.
9)  Byun JS, Fufa TD, Wakano C, Fernandez A, Haggerty CM, Sung MH, Gardner K.
ELL facilitates RNA polymerase II pause site entry and release.
Nat Commun. 3: 633, 2012.
10)  Sung MH, Hager GL.
Nonlinear dependencies of biochemical reactions for context-specific signaling dynamics.
Sci Rep. 2: 616, 2012.
11)  John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, Hager GL, Stamatoyannopoulos JA.
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.
Nat. Genet. 43: 264-8, 2011.
12)  Mazumdar M, Sung MH, Misteli T.
Chromatin maintenance by a molecular motor protein.
Nucleus. 2, 2011.
13)  Hakim O, Sung MH, Voss TC, Splinter E, John S, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, de Laat W, Hager GL.
Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements.
Genome Res. 21: 697-706, 2011.
14)  Wiench M, John S, Baek S, Johnson TA, Sung MH, Escobar T, Simmons CA, Pearce KH, Biddie SC, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, Hager GL.
DNA methylation status predicts cell type-specific enhancer activity.
EMBO J. 30: 3028-39, 2011.
15)  Voss TC, Schiltz RL, Sung MH, Yen PM, Stamatoyannopoulos JA, Biddie SC, Johnson TA, Miranda TB, John S, Hager GL.
Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism.
Cell. 2011.
16)  Siersbæk R, Nielsen R, John S, Sung MH, Baek S, Loft A, Hager GL, Mandrup S.
Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.
EMBO J. 30: 1459-72, 2011.
17)  Sung MH, Hager GL.
More to Hi-C than meets the eye.
Nat. Genet. 43: 1047-8, 2011.
18)  Biddie SC, John S, Sabo PJ, Thurman RE, Johnson TA, Schiltz RL, Miranda TB, Sung MH, Trump S, Lightman SL, Vinson C, Stamatoyannopoulos JA, Hager GL.
Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding.
Mol. Cell. 43: 145-55, 2011.
19)  Hakim O, Sung MH, Hager GL.
3D shortcuts to gene regulation.
Curr. Opin. Cell Biol. 22: 305-13, 2010.
20)  Sung MH, McNally JG.
Live cell imaging and systems biology.
Wiley interdisciplinary reviews. Systems biology and medicine. 2010.
21)  Voss TC, Schiltz RL, Sung MH, Johnson TA, John S, Hager GL.
Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity.
J. Cell. Sci. 122: 345-56, 2009.
22)  John S, Johnson TA, Sung MH, Biddie SC, Trump S, Koch-Paiz CA, Davis SR, Walker R, Meltzer PS, Hager GL.
Kinetic complexity of the global response to glucocorticoid receptor action.
Endocrinology. 150: 1766-74, 2009.
23)  Sung MH, Bagain L, Chen Z, Karpova T, Yang X, Silvin C, Voss T, McNally J, Van Waes C, Hager GL.
Dynamic Effect of Bortezomib on NF-{kappa}B Activity and Gene Expression in Tumor Cells.
Mol. Pharmacol. 2008.
24)  John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, Lightman SL, Voss TC, Davis SR, Meltzer PS, Stamatoyannopoulos JA, Hager GL.
Interaction of the glucocorticoid receptor with the chromatin landscape.
Mol. Cell. 29: 611-24, 2008.
25)  Dundr M, Ospina JK, Sung MH, John S, Upender M, Ried T, Hager GL, Matera AG.
Actin-dependent intranuclear repositioning of an active gene locus in vivo.
J. Cell Biol. 179: 1095-103, 2007.
26)  Zhao Y, Sung MH, Simon R.
Artificial intelligence methods for predicting T-cell epitopes.
Methods Mol. Biol. 409: 217-25, 2007.
27)  Cho KH, Baek S, Sung MH.
Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis.
FEBS Lett. 580: 3665-70, 2006.
28)  Zi Z, Cho KH, Sung MH, Xia X, Zheng J, Sun Z.
In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway.
FEBS Lett. 579: 1101-8, 2005.
29)  Sung MH, Simon R.
Candidate epitope identification using peptide property models: application to cancer immunotherapy.
Methods. 34: 460-7, 2004.
30)  Bielekova B, Sung MH, Kadom N, Simon R, McFarland H, Martin R.
Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis.
J Immunol. 172: 3893-904, 2004.
31)  Sung MH, Simon R.
Genomewide conserved epitope profiles of HIV-1 predicted by biophysical properties of MHC binding peptides.
J Comput Biol. 11: 125-45, 2004.
32)  Carr DB, Sung MH.
Graphs for Representing Statistics Indexed by Nucleotide or Amino Acid Sequences (COMSTAT, Proceeding in Computational Statistics).
. p. 73-84. [Meeting Proceeding]
33)  Sung MH, Simon R.
In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics.
Mol Pharmacol. 66: 70-5, 2004.
34)  Sung MH, Zhao Y, Martin R, Simon R.
T-cell epitope prediction with combinatorial peptide libraries.
J Comput Biol. 9: 527-39, 2002.
35)  Martin R, Gran B, Zhao Y, Markovic-Plese S, Bielekova B, Marques A, Sung MH, Hemmer B, Simon R, McFarland HF, Pinilla C.
Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease.
J Autoimmun. 16: 187-92, 2001.
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This page was last updated on 7/14/2014.