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Our Science – Meltzer Website

Paul S. Meltzer, M.D., Ph.D.

Selected Publications

1)  Gindin Y, Valenzuela MS, Aladjem MI, Meltzer PS, Bilke S.
A chromatin structure-based model accurately predicts DNA replication timing in human cells.
Mol. Syst. Biol. 10: 722, 2014.
[Journal]
2)  Subramanian M, Francis P, Bilke S, Li XL, Hara T, Lu X, Jones MF, Walker RL, Zhu Y, Pineda M, Lee C, Varanasi L, Yang Y, Martinez LA, Luo J, Ambs S, Sharma S, Wakefield LM, Meltzer PS, Lal A.
A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis.
Oncogene. [Epub ahead of print], 2014.
[Journal]
3)  Li XL, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, Walker RL, Pineda M, Zhu Y, Yang Y, Luo J, Wakefield LM, Brabletz T, Park BH, Sharma S, Chowdhury D, Meltzer PS, Lal A.
A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.
Mol. Cell. Biol. 34: 533-50, 2014.
[Journal]
4)  Gao R, Das BB, Chatterjee R, Abaan OD, Agama K, Matuo R, Vinson C, Meltzer PS, Pommier Y.
Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel.
DNA Repair (Amst.). 13: 1-9, 2014.
[Journal]
5)  Ellis RJ, Wang Y, Stevenson HS, Boufraqech M, Patel D, Nilubol N, Davis S, Edelman DC, Merino MJ, He M, Zhang L, Meltzer PS, Kebebew E.
Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype.
J. Clin. Endocrinol. Metab. 99: E329-37, 2014.
[Journal]
6)  Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS.
High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.
Nat. Genet. 46: 8-10, 2014.
[Journal]
7)  Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
J. Clin. Invest. 124: 398-412, 2014.
[Journal]
8)  Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD.
NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function.
Cancer Discov. 4: 564-77, 2014.
[Journal]
9)  Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton P, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Janeway KA, Weigel BJ, Randall RL, Meltzer PS, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Uren A, Patel S, Trent JM, Savage SA, Mirabello L, Reinke D, Barkauskas DA, Smith MA, Bernstein ML, Kirsch DG, Krailo MD.
Towards a Drug Development Path that Targets Metastatic Progression in Osteosarcoma.
Clin. Cancer Res. [Epub ahead of print], 2014.
[Journal]
10)  Trucco MM, Awad O, Wilky BA, Goldstein SD, Huang R, Walker RL, Shah P, Katuri V, Gul N, Zhu YJ, McCarthy EF, Paz-Priel I, Meltzer PS, Austin CP, Xia M, Loeb DM.
A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-?B signaling in chordoma biology.
PLoS ONE. 8: e79950, 2013.
[Journal]
11)  Praetorius C, Grill C, Stacey SN, Metcalf AM, Gorkin DU, Robinson KC, Van Otterloo E, Kim RS, Bergsteinsdottir K, Ogmundsdottir MH, Magnusdottir E, Mishra PJ, Davis SR, Guo T, Zaidi MR, Helgason AS, Sigurdsson MI, Meltzer PS, Merlino G, Petit V, Larue L, Loftus SK, Adams DR, Sobhiafshar U, Emre NC, Pavan WJ, Cornell R, Smith AG, McCallion AS, Fisher DE, Stefansson K, Sturm RA, Steingrimsson E.
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.
Cell. 155: 1022-33, 2013.
[Journal]
12)  Moreno-Smith M, Halder JB, Meltzer PS, Gonda TA, Mangala LS, Rupaimoole R, Lu C, Nagaraja AS, Gharpure KM, Kang Y, Rodriguez-Aguayo C, Vivas-Mejia PE, Zand B, Schmandt R, Wang H, Langley RR, Jennings NB, Ivan C, Coffin JE, Armaiz GN, Bottsford-Miller J, Kim SB, Halleck MS, Hendrix MJ, Bornman W, Bar-Eli M, Lee J, Siddik ZH, Lopez-Berestein G, Sood AK.
ATP11B mediates platinum resistance in ovarian cancer.
J. Clin. Invest. 123: 2119-30, 2013.
[Journal]
13)  Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng S, Santoro M, Garcia-Rostan G, Kelly K.
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
Oncogene. 32: 2726-38, 2013.
[Journal]
14)  Tan X, Anzick SL, Khan SG, Ueda T, Stone G, Digiovanna JJ, Tamura D, Wattendorf D, Busch D, Brewer CC, Zalewski C, Butman JA, Griffith AJ, Meltzer PS, Kraemer KH.
Chimeric Negative Regulation of p14ARF and TBX1 by a t(9;22) Translocation Associated with Melanoma, Deafness, and DNA Repair Deficiency.
Hum. Mutat. 34: 1250-9, 2013.
[Journal]
15)  Hirsch D, Kemmerling R, Davis S, Camps J, Meltzer PS, Ried T, Gaiser T.
Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma.
Cancer Res. 73: 1454-60, 2013.
[Journal]
16)  Kim DW, Walker RL, Meltzer PS, Cheng S.
Complex temporal changes in TGFß oncogenic signaling drive thyroid carcinogenesis in a mouse model.
Carcinogenesis. 34: 2389-400, 2013.
[Journal]
17)  Petrini I, Wang Y, Zucali PA, Lee HS, Pham T, Voeller D, Meltzer PS, Giaccone G.
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.
Clin. Cancer Res. 19: 1960-71, 2013.
[Journal]
18)  Voortman J, Harada T, Chang RP, Killian JK, Suuriniemi M, Smith WI, Meltzer PS, Lucchi M, Wang Y, Giaccone G.
Detection and therapeutic implications of c-Met mutations in small cell lung cancer and neuroendocrine tumors.
Curr. Pharm. Des. 19: 833-40, 2013.
[Journal]
19)  Kang Z, Yu Y, Zhu YJ, Davis S, Walker R, Meltzer PS, Helman LJ, Cao L.
Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma.
Oncogene. [Epub ahead of print], 2013.
[Journal]
20)  Savage SA, Mirabello L, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, Flanagan AM, Tirabosco R, Andrulis IL, Wunder JS, Gokgoz N, Patiño-Garcia A, Sierrasesúmaga L, Lecanda F, Kurucu N, Ilhan IE, Sari N, Serra M, Hattinger C, Picci P, Spector LG, Barkauskas DA, Marina N, de Toledo SR, Petrilli AS, Amary MF, Halai D, Thomas DM, Douglass C, Meltzer PS, Jacobs K, Chung CC, Berndt SI, Purdue MP, Caporaso NE, Tucker M, Rothman N, Landi MT, Silverman DT, Kraft P, Hunter DJ, Malats N, Kogevinas M, Wacholder S, Troisi R, Helman L, Fraumeni JF, Yeager M, Hoover RN, Chanock SJ.
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
Nat. Genet. 45: 799-803, 2013.
[Journal]
21)  Miettinen M, Killian JK, Wang ZF, Lasota J, Lau C, Jones L, Walker R, Pineda M, Zhu YJ, Kim SY, Helman L, Meltzer P.
Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation.
Am. J. Surg. Pathol. 37: 234-40, 2013.
[Journal]
22)  Klorin G, Rozenblum E, Glebov O, Walker RL, Park Y, Meltzer PS, Kirsch IR, Kaye FJ, Roschke AV.
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.
Cancer Genet. 206: 191-205, 2013.
[Journal]
23)  Teer JK, Johnston JJ, Anzick SL, Pineda M, Stone G, Meltzer PS, Mullikin JC, Biesecker LG.
Massively-parallel sequencing of genes on a single chromosome: a comparison of solution hybrid selection and flow sorting.
BMC Genomics. 14: 253, 2013.
[Journal]
24)  Bilke S, Schwentner R, Yang F, Kauer MO, Jug G, Walker RL, Davis S, Zhu YJ, Pineda M, Meltzer PS, Kovar H.
Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer.
Genome Res. 23: 1797-809, 2013.
[Journal]
25)  Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, Rini BI, Srinivas S, Stein MN, Adams LM, Ottesen LH, Laubscher KH, Sherman L, McDermott DF, Haas NB, Flaherty KT, Ross R, Eisenberg P, Meltzer PS, Merino MJ, Bottaro DP, Linehan WM, Srinivasan R.
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.
J. Clin. Oncol. 31: 181-6, 2013.
[Journal]
26)  Kelly L, Bryan K, Kim SY, Janeway KA, Killian JK, Schildhaus HU, Miettinen M, Helman L, Meltzer PS, van de Rijn M, Debiec-Rychter M, O'Sullivan M.
Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].
PLoS ONE. 8: e64102, 2013.
[Journal]
27)  Webster LR, Provan PJ, Graham DJ, Byth K, Walker RL, Davis S, Salisbury EL, Morey AL, Ward RL, Hawkins NJ, Clarke CL, Meltzer PS, Balleine RL.
Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.
Pathology. 45: 629-36, 2013.
[Journal]
28)  Kikuchi K, Taniguchi E, Chen HI, Svalina MN, Abraham J, Huang ET, Nishijo K, Davis S, Louden C, Zarzabal LA, Recht O, Bajwa A, Berlow N, Suelves M, Perkins SL, Meltzer PS, Mansoor A, Michalek JE, Chen Y, Rubin BP, Keller C.
Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma.
Skelet Muscle. 3: 27, 2013.
[Journal]
29)  Zhang H, Meltzer P, Davis S.
RCircos: an R package for Circos 2D track plots.
BMC Bioinformatics. 14: 244, 2013.
[Journal]
30)  Zhu Y, Stephens RM, Meltzer PS, Davis SR.
SRAdb: query and use public next-generation sequencing data from within R.
BMC Bioinformatics. 14: 19, 2013.
[Journal]
31)  Killian JK, Kim SY, Miettinen M, Smith C, Merino M, Tsokos M, Quezado M, Smith WI, Jahromi MS, Xekouki P, Szarek E, Walker R, Lasota J, Raffeld M, Klotzle B, Wang Z, Jones L, Zhu YJ, Wang Y, Waterfall J, O'Sullivan M, Bibikova M, Pacak K, Stratakis CA, Janeway KA, Schiffman JD, Fan J, Helman LJ, Meltzer PS.
Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor.
Cancer Discov. 3: 648-57, 2013.
[Journal]
32)  Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73: 4372-82, 2013.
[Journal]
33)  Azad N, Yu M, Davidson B, Choyke P, Chen CC, Wood BJ, Venkatesan A, Henning R, Calvo K, Minasian L, Edelman DC, Meltzer P, Steinberg SM, Annunziata CM, Kohn EC.
Translational predictive biomarker analysis of the phase 1b sorafenib and bevacizumab study expansion cohort.
Mol. Cell Proteomics. 12: 1621-31, 2013.
[Journal]
34)  O'Shea PJ, Kim DW, Logan JG, Davis S, Walker RL, Meltzer PS, Cheng S, Williams GR.
Advanced Bone Formation in Mice with a Dominant-negative Mutation in the Thyroid Hormone Receptor Beta Gene due to Activation of Wnt/beta-Catenin Protein Signaling.
J. Biol. Chem. 287: 17812-22, 2012.
[Journal]
35)  Valenzuela MS, Hu L, Lueders J, Walker R, Meltzer PS.
Broader utilization of origins of DNA replication in cancer cell lines along a 78 kb region of human chromosome 2q34.
J. Cell. Biochem. 113: 132-40, 2012.
[Journal]
36)  Gartner JJ, Davis S, Wei X, Lin JC, Trivedi NS, Teer JK, Meltzer PS, Rosenberg SA, Samuels Y.
Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma.
BMC Genomics. 13: 505, 2012.
[Journal]
37)  Petrini I, Meltzer PS, Zucali PA, Luo J, Lee C, Santoro A, Lee HS, Killian KJ, Wang Y, Tsokos M, Roncalli M, Steinberg SM, Wang Y, Giaccone G.
Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors.
Cell Death Dis. 3: e351, 2012.
[Journal]
38)  Rechache NS, Wang Y, Stevenson HS, Killian JK, Edelman DC, Merino M, Zhang L, Nilubol N, Stratakis CA, Meltzer PS, Kebebew E.
DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors.
J. Clin. Endocrinol. Metab. 97: E1004-13, 2012.
[Journal]
39)  Beachy SH, Onozawa M, Chung YJ, Slape C, Bilke S, Francis P, Pineda M, Walker RL, Meltzer P, Aplan PD.
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma.
Blood. 120: 1048-59, 2012.
[Journal]
40)  Kouprina N, Lee NC, Pavlicek A, Samoshkin A, Kim JH, Lee HS, Varma S, Reinhold WC, Otstot J, Solomon G, Davis S, Meltzer PS, Schleutker J, Larionov V.
Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.
Genes Chromosomes Cancer. 51: 933-48, 2012.
[Journal]
41)  Baysan M, Bozdag S, Cam MC, Kotliarova S, Ahn S, Walling J, Killian JK, Stevenson H, Meltzer P, Fine HA.
G-cimp status prediction of glioblastoma samples using mRNA expression data.
PLoS ONE. 7: e47839, 2012.
[Journal]
42)  Killian JK, Walker RL, Bilke S, Chen Y, Davis S, Cornelison R, Smith WI, Meltzer PS.
Genome-wide methylation profiling in archival formalin-fixed paraffin-embedded tissue samples.
Methods Mol. Biol. 823: 107-18, 2012.
[Journal]
43)  Warren KE, Killian K, Suuriniemi M, Wang Y, Quezado M, Meltzer PS.
Genomic aberrations in pediatric diffuse intrinsic pontine gliomas.
Neuro-oncology. 14: 326-32, 2012.
[Journal]
44)  Debbache J, Raza Zaidi M, Davis S, Guo T, Bismuth K, Wang X, Skuntz S, Maric D, Pickel J, Meltzer P, Merlino G, Arnheiter H.
In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.
Genetics. 191: 133-44, 2012.
[Journal]
45)  Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW.
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.
Gastroenterology. 142: 957-966.e12, 2012.
[Journal]
46)  Gao Y, Killian K, Zhang H, Yu K, Li QZ, Weinstein S, Virtamo J, Tucker M, Taylor P, Albanes D, Meltzer P, Caporaso N.
Leukocyte DNA methylation and colorectal cancer among male smokers.
World J Gastrointest Oncol. 4: 193-201, 2012.
[Journal]
47)  Lee JH, Giovannetti E, Hwang JH, Petrini I, Wang Q, Voortman J, Wang Y, Steinberg SM, Funel N, Meltzer PS, Wang Y, Giaccone G.
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Clin. Cancer Res. 18: 524-33, 2012.
[Journal]
48)  Parker SC, Gartner J, Cardenas-Navia I, Wei X, Ozel Abaan H, Ajay SS, Hansen NF, Song L, Bhanot UK, Killian JK, Gindin Y, Walker RL, Meltzer PS, Mullikin JC, Furey TS, Crawford GE, Rosenberg SA, Samuels Y, Margulies EH.
Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.
PLoS Genet. 8: e1002871, 2012.
[Journal]
49)  Chatterjee R, Zhao J, He X, Shlyakhtenko A, Mann I, Waterfall JJ, Meltzer P, Sathyanarayana BK, FitzGerald PC, Vinson C.
Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPa and CREB proteins.
G3 (Bethesda). 2: 1243-56, 2012.
[Journal]
50)  Cunliffe HE, Jiang Y, Fornace KM, Yang F, Meltzer PS.
PAR6B is required for tight junction formation and activated PKC? localization in breast cancer.
Am J Cancer Res. 2: 478-91, 2012.
[Journal]
51)  Kemp CD, Rao M, Xi S, Inchauste S, Mani H, Fetsch P, Filie A, Zhang M, Hong JA, Walker RL, Zhu YJ, Ripley RT, Mathur A, Liu F, Yang M, Meltzer PA, Marquez VE, De Rienzo A, Bueno R, Schrump DS.
Polycomb repressor complex-2 is a novel target for mesothelioma therapy.
Clin. Cancer Res. 18: 77-90, 2012.
[Journal]
52)  Waterfall JJ, Meltzer PS.
Targeting epigenetic misregulation in synovial sarcoma.
Cancer Cell. 21: 323-4, 2012.
[Journal]
53)  Killian JK, Bilke S, Davis S, Walker RL, Jaeger E, Killian MS, Waterfall JJ, Bibikova M, Fan J, Smith WI, Meltzer PS.
A Methyl-Deviator Epigenotype of Estrogen Receptor-Positive Breast Carcinoma Is Associated with Malignant Biology.
Am. J. Pathol. 179: 55-65, 2011.
[Journal]
54)  Zoppoli G, Solier S, Reinhold WC, Liu H, Connelly JW, Monks A, Shoemaker RH, Abaan OD, Davis SR, Meltzer PS, Doroshow JH, Pommier Y.
CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.
Oncogene. 31: 403-18, 2011.
[Journal]
55)  Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C.
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.
Cancer Cell. 19: 177-91, 2011.
[Journal]
56)  Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome Res. 21: 1822-32, 2011.
[Journal]
57)  Meltzer PS, Helman LJ.
Genomic investigation of dedifferentiated liposarcoma suggests a role for therapeutic targeting of the tumor epigenome.
Cancer Discov. 1: 555-6, 2011.
[Journal]
58)  Lu C, Mishra A, Zhu YJ, Meltzer P, Cheng S.
Genomic profiling of genes contributing to metastasis in a mouse model of thyroid follicular carcinoma.
Am. J. Cancer Res. 1: 1-13, 2011.
[Journal]
59)  Lu C, Mishra A, Zhu YJ, Meltzer P, Cheng S.
Global expression profiling reveals gain-of-function oncogenic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis.
Am. J. Cancer Res. 1: 168-191, 2011.
[Journal]
60)  Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D.
Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
Clin. Exp. Metastasis. 28: 899-908, 2011.
[Journal]
61)  Zaidi MR, Davis S, Noonan FP, Graff-Cherry C, Hawley TS, Walker RL, Feigenbaum L, Fuchs E, Lyakh L, Young HA, Hornyak TJ, Arnheiter H, Trinchieri G, Meltzer PS, De Fabo EC, Merlino G.
Interferon-γ links ultraviolet radiation to melanomagenesis in mice.
Nature. 469: 548-53, 2011.
[Journal]
62)  Meltzer P.
Melanoma Researchers Have a Reason to GRIN: Melanoma Yields More of Its Secrets to Exome Sequencing.
Pigment Cell Melanoma Res. 24: 590-1, 2011.
[Journal]
63)  Eberle FC, Rodriguez-Canales J, Wei L, Hanson JC, Killian JK, Sun HW, Adams LG, Hewitt SM, Wilson WH, Pittaluga S, Meltzer PS, Staudt LM, Emmert-Buck MR, Jaffe ES.
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.
Haematologica. 96: 558-66, 2011.
[Journal]
64)  Valenzuela MS, Chen Y, Davis S, Yang F, Walker RL, Bilke S, Lueders J, Martin MM, Aladjem MI, Massion PP, Meltzer PS.
Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences.
PLoS ONE. 6: e17308, 2011.
[Journal]
65)  Killian JK, Walker RL, Suuriniemi M, Jones L, Scurci S, Singh P, Cornelison R, Harmon S, Boisvert N, Zhu J, Wang Y, Bilke S, Davis S, Giaccone G, Smith WI, Meltzer PS.
Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling.
J Mol Diagn. 12: 739-45, 2010.
[Journal]
66)  Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI, Meltzer P, Wang Y, Giaccone G.
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proc. Natl. Acad. Sci. U.S.A. 107: 13040-5, 2010.
[Journal]
67)  Bolton KL, Garcia-Closas M, Pfeiffer RM, Duggan MA, Howat WJ, Hewitt SM, Yang XR, Cornelison R, Anzick SL, Meltzer P, Davis S, Lenz P, Figueroa JD, Pharoah PD, Sherman ME.
Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies.
Cancer Epidemiol. Biomarkers Prev. 19: 992-9, 2010.
[Journal]
68)  Komiya T, Coxon A, Park Y, Chen WD, Zajac-Kaye M, Meltzer P, Karpova T, Kaye FJ.
Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.
Oncogene. 29: 1672-80, 2010.
[Journal]
69)  Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, Rao M, Meltzer PA, Schrump DS.
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.
Oncogene. 29: 3650-64, 2010.
[Journal]
70)  Petrini I, Zucali PA, Lee HS, Pineda MA, Meltzer PS, Walter-Rodriguez B, Roncalli M, Santoro A, Wang Y, Giaccone G.
Expression and Mutational Status of c-kit in Thymic Epithelial Tumors.
J Thorac Oncol. 5: 1447-53, 2010.
[Journal]
71)  Cao L, Yu Y, Bilke S, Walker RL, Mayeenuddin LH, Azorsa DO, Yang F, Pineda M, Helman LJ, Meltzer PS.
Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.
Cancer Res. 70: 6497-508, 2010.
[Journal]
72)  Morisot S, Wayne AS, Bohana-Kashtan O, Kaplan IM, Gocke CD, Hildreth R, Stetler-Stevenson M, Walker RL, Davis S, Meltzer PS, Wheelan SJ, Brown P, Jones RJ, Shultz LD, Civin CI.
High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias.
Leukemia. 24: 1859-66, 2010.
[Journal]
73)  Aryee DN, Niedan S, Kauer M, Schwentner R, Bennani-Baiti IM, Ban J, Muehlbacher K, Kreppel M, Walker RL, Meltzer P, Poremba C, Kofler R, Kovar H.
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro.
Cancer Res. 70: 4015-23, 2010.
[Journal]
74)  Brüderlein S, Sommer JB, Meltzer PS, Li S, Osada T, Ng D, Möller P, Alcorta DA, Kelley MJ.
Molecular characterization of putative chordoma cell lines.
Sarcoma. 2010: 630129, 2010.
[Journal]
75)  Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK, Kaye FJ.
Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions.
Genes Chromosomes Cancer. 49: 59-69, 2010.
[Journal]
76)  Kauer M, Ban J, Kofler R, Walker B, Davis S, Meltzer P, Kovar H.
A molecular function map of Ewing's sarcoma.
PLoS ONE. 4: e5415, 2009.
[Journal]
77)  Palmieri D, Fitzgerald D, Shreeve SM, Hua E, Bronder JL, Weil RJ, Davis S, Stark AM, Merino MJ, Kurek R, Mehdorn HM, Davis G, Steinberg SM, Meltzer PS, Aldape K, Steeg PS.
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Mol. Cancer Res. 7: 1438-45, 2009.
[Journal]
78)  Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, Hewitt S, Triche T, Meltzer P, Khanna C.
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
BMC Genomics. 10: 625, 2009.
[Journal]
79)  John S, Johnson TA, Sung MH, Biddie SC, Trump S, Koch-Paiz CA, Davis SR, Walker R, Meltzer PS, Hager GL.
Kinetic complexity of the global response to glucocorticoid receptor action.
Endocrinology. 150: 1766-74, 2009.
[Journal]
80)  Killian JK, Bilke S, Davis S, Walker RL, Killian MS, Jaeger EB, Chen Y, Hipp J, Pittaluga S, Raffeld M, Cornelison R, Smith WI, Bibikova M, Fan JB, Emmert-Buck MR, Jaffe ES, Meltzer PS.
Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome.
Cancer Res. 69: 758-64, 2009.
[Journal]
81)  Gartside MG, Chen H, Ibrahimi OA, Byron SA, Curtis AV, Wellens CL, Bengston A, Yudt LM, Eliseenkova AV, Ma J, Curtin JA, Hyder P, Harper UL, Riedesel E, Mann GJ, Trent JM, Bastian BC, Meltzer PS, Mohammadi M, Pollock PM.
Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma.
Mol. Cancer Res. 7: 41-54, 2009.
[Journal]
82)  Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.
MicroRNA expression, survival, and response to interferon in liver cancer.
N. Engl. J. Med. 361: 1437-47, 2009.
[Journal]
83)  Wang D, Xia X, Liu Y, Oetting A, Walker RL, Zhu Y, Meltzer P, Cole PA, Shi YB, Yen PM.
Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.
Mol. Endocrinol. 23: 600-9, 2009.
[Journal]
84)  Kralj JG, Player A, Sedrick H, Munson MS, Petersen D, Forry SP, Meltzer P, Kawasaki E, Locascio LE.
T7-based linear amplification of low concentration mRNA samples using beads and microfluidics for global gene expression measurements.
Lab Chip. 9: 917-24, 2009.
[Journal]
85)  Palmieri D, Lockman PR, Thomas FC, Hua E, Herring J, Hargrave E, Johnson M, Flores N, Qian Y, Vega-Valle E, Taskar KS, Rudraraju V, Mittapalli RK, Gaasch JA, Bohn KA, Thorsheim HR, Liewehr DJ, Davis S, Reilly JF, Walker R, Bronder JL, Feigenbaum L, Steinberg SM, Camphausen K, Meltzer PS, Richon VM, Smith QR, Steeg PS.
Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.
Clin. Cancer Res. 15: 6148-57, 2009.
[Journal]
86)  Chen HI, Hsu FH, Jiang Y, Tsai MH, Yang PC, Meltzer PS, Chuang EY, Chen Y.
A probe-density-based analysis method for array CGH data: simulation, normalization and centralization.
Bioinformatics. 24: 1749-56, 2008.
[Journal]
87)  Farrar JE, Nater M, Caywood E, McDevitt MA, Kowalski J, Takemoto CM, Talbot CC, Meltzer P, Esposito D, Beggs AH, Schneider HE, Grabowska A, Ball SE, Niewiadomska E, Sieff CA, Vlachos A, Atsidaftos E, Ellis SR, Lipton JM, Gazda HT, Arceci RJ.
Abnormalities of the large ribosomal subunit protein, Rpl35A, in diamond-blackfan anemia.
Blood. 112: 1582-92, 2008.
[Journal]
88)  Zhu Y, Davis S, Stephens R, Meltzer PS, Chen Y.
GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus.
Bioinformatics. 24: 2798-800, 2008.
[Journal]
89)  Boyle AP, Davis S, Shulha HP, Meltzer P, Margulies EH, Weng Z, Furey TS, Crawford GE.
High-resolution mapping and characterization of open chromatin across the genome.
Cell. 132: 311-22, 2008.
[Journal]
90)  Amundson SA, Do KT, Vinikoor LC, Lee RA, Koch-Paiz CA, Ahn J, Reimers M, Chen Y, Scudiero DA, Weinstein JN, Trent JM, Bittner ML, Meltzer PS, Fornace AJ.
Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen.
Cancer Res. 68: 415-24, 2008.
[Journal]
91)  John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, Lightman SL, Voss TC, Davis SR, Meltzer PS, Stamatoyannopoulos JA, Hager GL.
Interaction of the glucocorticoid receptor with the chromatin landscape.
Mol. Cell. 29: 611-24, 2008.
[Journal]
92)  Fleming JM, Long EL, Ginsburg E, Gerscovich D, Meltzer PS, Vonderhaar BK.
Interlobular and intralobular mammary stroma: genotype may not reflect phenotype.
BMC Cell Biol. 9: 46, 2008.
[Journal]
93)  Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, Kaye FJ.
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.
Cell Cycle. 7: 2384-91, 2008.
[Journal]
94)  Balleine RL, Webster LR, Davis S, Salisbury EL, Palazzo JP, Schwartz GF, Cornfield DB, Walker RL, Byth K, Clarke CL, Meltzer PS.
Molecular grading of ductal carcinoma in situ of the breast.
Clin. Cancer Res. 14: 8244-52, 2008.
[Journal]
95)  Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J.
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
Science. 320: 539-43, 2008.
[Journal]
96)  Eckstrand K, Addington AM, Stromberg T, Merriman B, Miller R, Gochman P, Long R, Dutra A, Chen Z, Meltzer P, Nelson SF, Rapoport JL.
Sex chromosome anomalies in childhood onset schizophrenia: an update.
Mol. Psychiatry. 13: 910-1, 2008.
[Journal]
97)  Bhoumik A, Fichtman B, Derossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z.
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer.
Proc. Natl. Acad. Sci. U.S.A. 105: 1674-9, 2008.
[Journal]
98)  Rahman M, Davis SR, Pumphrey JG, Bao J, Nau MM, Meltzer PS, Lipkowitz S.
TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.
Breast Cancer Res. Treat. 2008.
[Journal]
99)  Quignodon L, Grijota-Martinez C, Compe E, Guyot R, Allioli N, Laperriere D, Walker R, Meltzer P, Mader S, Samarut J, Flamant F.
A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum.
J. Mol. Endocrinol. 39: 17-28, 2007.
[Journal]
100)  Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, Dissanayake SK, Earley R, Indig FE, Nickoloff BJ, Taub DD, Kallioniemi OP, Meltzer P, Morin PJ, Weeraratna AT.
Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.
Oncogene. 26: 3846-56, 2007.
[Journal]
101)  Kim KT, Baird K, Davis S, Piloto O, Levis M, Li L, Chen P, Meltzer P, Small D.
Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells.
Br. J. Haematol. 138: 603-15, 2007.
[Journal]
102)  Kamradt J, Jung V, Wahrheit K, Tolosi L, Rahnenfuehrer J, Schilling M, Walker R, Davis S, Stoeckle M, Meltzer P, Wullich B.
Detection of novel amplicons in prostate cancer by comprehensive genomic profiling of prostate cancer cell lines using oligonucleotide-based arrayCGH.
PLoS ONE. 2: e769, 2007.
[Journal]
103)  Bruce B, Khanna G, Ren L, Landberg G, Jirstrom K, Powell C, Borczuk A, Keller ET, Wojno KJ, Meltzer P, Baird K, McClatchey A, Bretscher A, Hewitt SM, Khanna C.
Expression of the cytoskeleton linker protein ezrin in human cancers.
Clin. Exp. Metastasis. 24: 69-78, 2007.
[Journal]
104)  Sean D, Meltzer PS.
GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor.
Bioinformatics. 23: 1846-7, 2007.
[Journal]
105)  Meltzer PS.
Is Ewing's sarcoma a stem cell tumor?.
Cell stem cell. 1: 13-5, 2007.
[Journal]
106)  Davis SR, Meltzer PS.
Modeling synovial sarcoma: timing is everything.
Cancer Cell. 11: 305-7, 2007.
[Journal]
107)  Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS.
Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.
Cancer Res. 67: 7238-46, 2007.
[Journal]
108)  Johnston JJ, Walker RL, Davis S, Facio F, Turner JT, Bick DP, Daentl DL, Ellison JW, Meltzer PS, Biesecker LG.
Zoom-in comparative genomic hybridisation arrays for the characterisation of variable breakpoint contiguous gene syndromes.
J. Med. Genet. 44: e59, 2007.
[Journal]
109)  Crawford GE, Davis S, Scacheri PC, Renaud G, Halawi MJ, Erdos MR, Green R, Meltzer PS, Wolfsberg TG, Collins FS.
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays.
Nat. Methods. 3: 503-9, 2006.
[Journal]
110)  Davis S, Meltzer PS.
Ewing's sarcoma: general insights from a rare model.
Cancer Cell. 9: 331-2, 2006.
[Journal]
111)  Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS.
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
PLoS Genet. 2: e51, 2006.
[Journal]
112)  de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA.
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
J. Cell Biol. 175: 661-70, 2006.
[Journal]
113)  Li HM, Man C, Jin Y, Deng W, Yip YL, Feng HC, Cheung YC, Lo KW, Meltzer PS, Wu ZG, Kwong YL, Yuen AP, Tsao SW.
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase.
Int. J. Cancer. 119: 1567-76, 2006.
[Journal]
114)  Seftor E, Meltzer P, Kirschmann DA, Margaryan N, Seftor R, Hendrix M.
The epigenetic reprogramming of poorly aggressive melanoma cells by a metastatic microenvironment.
J. Cell. Mol. Med. 10: 174-96, 2006.
[Journal]
115)  de Bruijn DR, Allander SV, van Dijk AH, Willemse MP, Thijssen J, van Groningen JJ, Meltzer PS, Geurts van Kessel A.
The Synovial Sarcoma-Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)Regulation.
Cancer Res. 66: 9474-82, 2006.
[Journal]
116)  Furumoto H, Ying H, Chandramouli GV, Zhao L, Walker RL, Meltzer PS, Willingham MC, Cheng SY.
An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.
Mol. Cell. Biol. 25: 124-35, 2005.
[Journal]
117)  Meltzer PS.
Cancer genomics: small RNAs with big impacts.
Nature. 435: 745-6, 2005.
[Journal]
118)  Baird K, Davis S, Antonescu CR, Harper UL, Walker RL, Chen Y, Glatfelter AA, Duray PH, Meltzer PS.
Gene expression profiling of human sarcomas: insights into sarcoma biology.
Cancer Res. 65: 9226-35, 2005.
[Journal]
119)  Meltzer PS.
Genetic diversity in melanoma.
N. Engl. J. Med. 353: 2104-7, 2005.
[Journal]
120)  Moeller LC, Dumitrescu AM, Walker RL, Meltzer PS, Refetoff S.
Thyroid hormone responsive genes in cultured human fibroblasts.
J. Clin. Endocrinol. Metab. 90: 936-43, 2005.
[Journal]
121)  Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B.
CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.
Nat. Med. 10: 374-81, 2004.
[Journal]
122)  Sood R, Bader PI, Speer MC, Edwards YH, Eddings EM, Blair RT, Hu P, Faruque MU, Robbins CM, Zhang H, Leuders J, Morrison K, Thompson D, Schwartzberg PL, Meltzer PS, Trent JM.
Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis.
Cytogenet. Genome Res. 106: 61-7, 2004.
[Journal]
123)  Barrett MT, Scheffer A, Ben-Dor A, Sampas N, Lipson D, Kincaid R, Tsang P, Curry B, Baird K, Meltzer PS, Yakhini Z, Bruhn L, Laderman S.
Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA.
Proc. Natl. Acad. Sci. U.S.A. 101: 17765-70, 2004.
[Journal]
124)  Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Nat. Med. 10: 175-81, 2004.
[Journal]
125)  Koch-Paiz CA, Amundson SA, Bittner ML, Meltzer PS, Fornace AJ.
Functional genomics of UV radiation responses in human cells.
Mutat. Res. 549: 65-78, 2004.
[Journal]
126)  Meltzer PS.
Gene expression profiling in breast cancer research.
Breast Dis. 19: 23-7, 2004.
[Journal]
127)  Weeraratna AT, Becker D, Carr KM, Duray PH, Rosenblatt KP, Yang S, Chen Y, Bittner M, Strausberg RL, Riggins GJ, Wagner U, Kallioniemi OP, Trent JM, Morin PJ, Meltzer PS.
Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome.
Oncogene. 23: 2264-74, 2004.
[Journal]
128)  Håkansson P, Segal D, Lassen C, Gullberg U, Morse HC, Fioretos T, Meltzer PS.
Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays.
Exp. Hematol. 32: 476-82, 2004.
[Journal]
129)  Gruvberger-Saal SK, Edén P, Ringnér M, Baldetorp B, Chebil G, Borg A, Fernö M, Peterson C, Meltzer PS.
Predicting continuous values of prognostic markers in breast cancer from microarray gene expression profiles.
Mol. Cancer Ther. 3: 161-8, 2004.
[Journal]
130)  Smith AP, Weeraratna AT, Spears JR, Meltzer PS, Becker D.
SAGE identification and fluorescence imaging analysis of genes and transcripts in melanomas and precursor lesions.
Cancer Biol. Ther. 3: 104-9, 2004.
[Journal]
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This page was last updated on 5/8/2014.