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Our Science – Tosato Website

Giovanna Tosato, M.D.

Selected Publications

1)  Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick TS, Yarchoan R, Tosato G.
A20/TNFAIP3 inhibits NF-kappaB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.
Oncogene. 32: 1223-32, 2012.
2)  Salvucci O, Tosato G.
Essential Roles of EphB Receptors and EphrinB Ligands in Endothelial Cell Function and Angiogenesis.
Adv. Cancer Res. 114: 21-57, 2012.
3)  Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S.
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Blood. 119: 5173-81, 2012.
4)  Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R, Tosato G.
Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling.
Cancer Res. 72: 1157-69, 2012.
5)  Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, Espigol-Frigole G, Wang S, Tosato G.
MicroRNA126 contributes to G-CSF-induced hematopoietic progenitor cell mobilization by reducing VCAM-1 expression.
Haematologica. 97: 818-26, 2012.
6)  Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G.
Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Blood. 120: 4104-15, 2012.
7)  Ciraci E, Della Bella S, Salvucci O, Rofani C, Segarra M, Bason C, Molinari A, Maric D, Tosato G, Berardi AC.
Adult human circulating CD34-Lin-CD45-CD133- cells can differentiate into hematopoietic and endothelial cells.
Blood. 118: 2105-15, 2011.
8)  Uldrick TS, Polizzotto MN, Aleman K, O'Mahony D, Wyvill KM, Wang V, Marshall V, Pittaluga S, Steinberg SM, Tosato G, Whitby D, Little RF, Yarchoan R.
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy.
Blood. 117: 6977-86, 2011.
9)  Sakakibara S, Sakakibara K, Tosato G.
NF-kappaB activation stimulates transcription and replication of retrovirus XMRV in human B-lineage and prostate carcinoma cells.
J. Virol. 85: 3179-86, 2011.
10)  Noberini R, Mitra S, Salvucci O, Valencia F, Duggineni S, Prigozhina N, Wei K, Tosato G, Huang Z, Pasquale EB.
PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity.
PLoS ONE. 6: e28611, 2011.
11)  Sakakibara S, Tosato G.
Viral Interleukin-6: Role in Kaposi's Sarcoma-Associated Herpesvirus-Associated Malignancies.
J. Interferon Cytokine Res. 31: 791-801, 2011.
12)  Uldrick TS, Wang V, O'Mahony D, Aleman K, Wyvill KM, Marshall V, Steinberg SM, Pittaluga S, Maric I, Whitby D, Tosato G, Little RF, Yarchoan R.
An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease.
Clin. Infect. Dis. 51: 350-8, 2010.
13)  Tosato G, Segarra M, Salvucci O.
Cytosolic phospholipase A2{alpha} and cancer: a role in tumor angiogenesis.
J. Natl. Cancer Inst. 102: 1377-9, 2010.
14)  Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G.
Oligo-guanosinenucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Blood. 116: 3099-107, 2010.
15)  de la Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick PJ, Segarra M, Stone J, Maric D, Zhu J, Qian X, Lowy DR, Tosato G.
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.
Blood. 115: 3970-9, 2010.
16)  Salvucci O, Maric D, Economopoulou M, Sakakibara S, Merlin S, Follenzi A, Tosato G.
EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.
Blood. 114: 1707-16, 2009.
17)  Sakakibara S, Pise-Masison CA, Brady JN, Tosato G.
Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells.
J. Virol. 83: 2140-53, 2009.
18)  McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G.
Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.
PLoS ONE. 4: e8102, 2009.
19)  Sakakibara S, Tosato G.
Regulation of angiogenesis in malignancies associated with Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus.
Future Microbiol. 4: 903-17, 2009.
20)  Gasperini P, Tosato G.
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma.
Leukemia. 23: 1867-74, 2009.
21)  Qian X, Li G, Vass W, Papageorge A, Asnaghi L, Tosato G, Hunter K, Lowy D.
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
Cancer Cell. 16: 246-58, 2009.
22)  Gasperini P, Sakakibara S, Tosato G.
Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis.
J. Leukoc. Biol. 84: 994-1000, 2008.
23)  Segarra M, Williams CK, Sierra MD, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P, Tosato G.
Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth.
Blood. 112: 1904-11, 2008.
24)  Narazaki M, Segarra M, Tosato G.
Neuropilin-2: a new molecular target for antiangiogenic and antitumor strategies.
J. Natl. Cancer Inst. 100: 81-3, 2008.
25)  McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G, Lefrancois S.
Palmitoylation controls recycling in lysosomal sorting and trafficking.
Traffic. 9: 1984-97, 2008.
26)  Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL.
Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.
Cancer Res. 68: 1889-95, 2008.
27)  Narazaki M, Segarra M, Tosato G.
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Blood. 111: 4126-36, 2008.
28)  Nakayama T, Mutsuga N, Tosato G.
Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and hematopoiesis.
J. Natl. Cancer Inst. 99: 223-35, 2007.
29)  Nakayama T, Mutsuga N, Tosato G.
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
Blood. 109: 1363-72, 2007.
30)  Tosato G, Cohen JI.
Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines.
Curr. Protoc. Immunol. Chapter 7: Unit 7.22, 2007.
31)  Aoki Y, Tosato G.
Interactions between HIV-1 Tat and KSHV.
Curr. Top. Microbiol. Immunol. 312: 309-26, 2007.
32)  Rhim JH, Tosato G.
Targeting the tumor vasculature to improve the efficacy of oncolytic virus therapy.
J. Natl. Cancer Inst. 99: 1739-41, 2007.
33)  Sierra MD, Gasperini P, McCormick P, Zhu J, Tosato G.
Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells.
Blood. 110: 2276-85, 2007.
34)  Yarchoan R, Pluda JM, Wyvill KM, Aleman K, Rodriguez-Chavez IR, Tosato G, Catanzaro AT, Steinberg SM, Little RF.
Treatment of AIDS-related Kaposi's sarcoma with interleukin-12: rationale and preliminary evidence of clinical activity.
Crit. Rev. Immunol. 27: 401-14, 2007.
35)  Little RF, Pluda JM, Wyvill KM, Rodriguez-Chavez IR, Tosato G, Catanzaro AT, Steinberg SM, Yarchoan R.
Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma.
Blood. 107: 4650-7, 2006.
36)  Narazaki M, Tosato G.
Canstatin: an inhibitor of angiogenesis and tumor growth revisited.
Cancer J. 12: 110-2, 2006.
37)  Narazaki M, Tosato G.
Conflicting results from clinical observations and murine models: what is the role of plasminogen activators in tumor growth?.
J. Natl. Cancer Inst. 98: 726-7, 2006.
38)  Salvucci O, Sierra MD, Martina JA, McCormick PJ, Tosato G.
EphB2 and EphB4 receptors forward signaling promotes SDF- 1-induced endothelial cell chemotaxis and branching remodeling.
Blood. 108: 2914-22, 2006.
39)  Kim HK, De La Luz Sierra M, Williams CK, Gulino AV, Tosato G.
G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells.
Blood. 108: 812-20, 2006.
40)  Narazaki M, Tosato G.
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Blood. 107: 3892-901, 2006.
41)  Huegel R, Velasco P, De La Luz Sierra M, Christophers E, Schröder JM, Schwarz T, Tosato G, Lange-Asschenfeldt B.
Novel Anti-Inflammatory Properties of the Angiogenesis Inhibitor Vasostatin.
J. Invest. Dermatol. 127: 65-74, 2006.
42)  Narazaki M, Tosato G.
Tumor cell populations differ in angiogenic activity: a model system for spontaneous angiogenic switch can tell us why.
J. Natl. Cancer Inst. 98: 294-5, 2006.
43)  Dunleavy K, Hakim F, Kim HK, Janik JE, Grant N, Nakayama T, White T, Wright G, Kwak L, Gress R, Tosato G, Wilson WH.
B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis.
Blood. 106: 795-802, 2005.
44)  Davis DA, Singer KE, De La Luz Sierra M, Narazaki M, Yang F, Fales HM, Yarchoan R, Tosato G.
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation.
Blood. 105: 4561-8, 2005.
45)  Aoki Y, Tosato G.
Lymphatic regeneration: new insights from VEGFR-3 blockade.
J Natl Cancer Inst. 97: 2-3, 2005.
46)  Murga M, Fernandez-Capetillo O, Tosato G.
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2.
Blood. 105: 1992-9, 2005.
47)  Nakayama T, Mutsuga N, Yao L, Tosato G.
Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells.
J. Leukoc. Biol. 79: 95-104, 2005.
48)  Bianco C, Strizzi L, Ebert A, Chang C, Rehman A, Normanno N, Guedez L, Salloum R, Ginsburg E, Sun Y, Khan N, Hirota M, Wallace-Jones B, Wechselberger C, Vonderhaar BK, Tosato G, Stetler-Stevenson WG, Sanicola M, Salomon DS.
Role of human cripto-1 in tumor angiogenesis.
J Natl Cancer Inst. 97: 132-41, 2005.
49)  Narazaki M, Tosato G.
Targeting coagulation to the tumor microvasculature: perspectives and therapeutic implications from preclinical studies.
J Natl Cancer Inst. 97: 705-7, 2005.
50)  Yarchoan R, Tosato G, Little RF.
Therapy insight: AIDS-related malignancies--the influence of antiviral therapy on pathogenesis and management.
Nat Clin Pract Oncol. 2: 406-15; quiz 423, 2005.
51)  Williams CK, Li J, Murga M, Harris AL, Tosato G.
Upregulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function.
Blood. 107: 931-9, 2005.
52)  Murga M, Yao L, Tosato G.
Derivation of endothelial cells from CD34- umbilical cord blood.
Stem Cells. 22: 385-95, 2004.
53)  De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, Yarchoan R, Zhang HH, Fales H, Tosato G.
Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity.
Blood. 103: 2452-9, 2004.
54)  Salvucci O, Basik M, Yao L, Bianchi R, Tosato G.
Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-alpha and IFN-gamma.
J Leukoc Biol. 76: 217-26, 2004.
55)  Aoki Y, Tosato G.
HIV-1 Tat enhances Kaposi sarcoma-associated herpesvirus (KSHV) infectivity.
Blood. 104: 810-4, 2004.
56)  Qiang YW, Yao L, Tosato G, Rudikoff S.
Insulin-like growth factor I induces migration and invasion of human multiple myeloma cells.
Blood. 103: 301-8, 2004.
57)  Nakayama T, Yao L, Tosato G.
Mast cell-derived angiopoietin-1 plays a critical role in the growth of plasma cell tumors.
J Clin Invest. 114: 1317-25, 2004.
58)  Aoki Y, Tosato G.
Neoplastic conditions in the context of HIV-1 infection.
Curr HIV Res. 2: 343-9, 2004.
59)  Aoki Y, Tosato G.
Therapeutic options for human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus-related disorders.
Expert Rev Anti Infect Ther. 2: 213-25, 2004.
60)  Little RF, Merced-Galindez F, Staskus K, Whitby D, Aoki Y, Humphrey R, Pluda JM, Marshall V, Walters M, Welles L, Rodriguez-Chavez IR, Pittaluga S, Tosato G, Yarchoan R.
A pilot study of cidofovir in patients with kaposi sarcoma.
J Infect Dis. 187: 149-53, 2003.
61)  Aoki Y, Feldman GM, Tosato G.
Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.
Blood. 101: 1535-42, 2003.
62)  Tosato G.
Interferon-alpha is implicated in the transcriptional regulation of vascular endothelial growth factor.
J Natl Cancer Inst. 95: 420-1, 2003.
63)  Aoki Y, Tosato G.
Pathogenesis and manifestations of human herpesvirus-8-associated disorders.
Semin Hematol. 40: 143-53, 2003.
64)  Yao L, Salvucci O, Cardones AR, Hwang ST, Aoki Y, De La Luz Sierra M, Sajewicz A, Pittaluga S, Yarchoan R, Tosato G.
Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.
Blood. 102: 3900-5, 2003.
65)  Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G.
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
J Leukoc Biol. 74: 880-8, 2003.
66)  Aoki Y, Tosato G.
Targeted inhibition of angiogenic factors in AIDS-related disorders.
Curr Drug Targets Infect Disord. 3: 115-28, 2003.
67)  Aoki Y, Tosato G.
Viral and cellular cytokines as therapeutic targets in AIDS-related lymphoproliferative disorders.
Curr Drug Targets Cardiovasc Haematol Disord. 3: 81-96, 2003.
68)  Yao L, Pike SE, Pittaluga S, Cherney B, Gupta G, Jaffe ES, Tosato G.
Anti-tumor activities of the angiogenesis inhibitors interferon-inducible protein-10 and the calreticulin fragment vasostatin.
Cancer Immunol Immunother. 51: 358-66, 2002.
69)  Kanegane H, Nomura K, Miyawaki T, Tosato G.
Biological aspects of Epstein-Barr virus (EBV)-infected lymphocytes in chronic active EBV infection and associated malignancies.
Crit Rev Oncol Hematol. 44: 239-49, 2002.
70)  Yao L, Pike SE, Tosato G.
Laminin binding to the calreticulin fragment vasostatin regulates endothelial cell function.
J Leukoc Biol. 71: 47-53, 2002.
71)  Salvucci O, Yao L, Villalba S, Sajewicz A, Pittaluga S, Tosato G.
Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1.
Blood. 99: 2703-11, 2002.
72)  Teruya-Feldstein J, Kingma DW, Weiss A, Sorbara L, Burd PR, Raffeld M, Mueller BU, Tosato G, Jaffe ES.
Chemokine gene expression and clonal analysis of B cells in tissues involved by lymphoid interstitial pneumonitis from HIV-infected pediatric patients.
Mod Pathol. 14: 929-36, 2001.
73)  Aoki Y, Yarchoan R, Wyvill K, Okamoto S, Little RF, Tosato G.
Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
Blood. 97: 2173-6, 2001.
74)  Taga K, Taga H, Tosato G.
Diagnosis of atypical cases of infectious mononucleosis.
Clin Infect Dis. 33: 83-8, 2001.
75)  Davis DA, Rinderknecht AS, Zoeteweij JP, Aoki Y, Read-Connole EL, Tosato G, Blauvelt A, Yarchoan R.
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.
Blood. 97: 3244-50, 2001.
76)  Yao L, Setsuda J, Sgadari C, Cherney B, Tosato G.
Interleukin-18 expression induced by Epstein-Barr virus-infected cells.
J Leukoc Biol. 69: 779-84, 2001.
77)  Hedvat CV, Jaffe ES, Qin J, Filippa DA, Cordon-Cardo C, Tosato G, Nimer SD, Teruya-Feldstein J.
Macrophage-derived chemokine expression in classical Hodgkin's lymphoma: application of tissue microarrays.
Mod Pathol. 14: 1270-6, 2001.
78)  Aoki Y, Narazaki M, Kishimoto T, Tosato G.
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.
Blood. 98: 3042-9, 2001.
79)  Aoki Y, Tosato G, Fonville TW, Pittaluga S.
Serum viral interleukin-6 in AIDS-related multicentric Castleman disease.
Blood. 97: 2526-7, 2001.
80)  Lange-Asschenfeldt B, Velasco P, Streit M, Hawighorst T, Pike SE, Tosato G, Detmar M.
The angiogenesis inhibitor vasostatin does not impair wound healing at tumor-inhibiting doses.
J Invest Dermatol. 117: 1036-41, 2001.
81)  Aoki Y, Tosato G.
Vascular endothelial growth factor/vascular permeability factor in the pathogenesis of primary effusion lymphomas.
Leuk Lymphoma. 41: 229-37, 2001.
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This page was last updated on 5/1/2013.