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Jung-Eun Park, Ph.D.

Selected Publications

1)  Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.
Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
Proc. Natl. Acad. Sci. U.S.A. 110: E4849-57, 2013.
2)  Park JE, Erikson RL, Lee KS.
Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate.
Proc. Natl. Acad. Sci. U.S.A. 108: 8200-5, 2011.
3)  Liu F, Park J, Qian W, Lim D, Graber M, Berg T, Yaffe MB, Lee KS, Burke TR.
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat. Chem. Biol. 7: 595-601, 2011.
4)  Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009.
5)  Yun S, Moulaei T, Lim D, Bang JK, Park J, Shenoy SR, Liu F, Kang YH, Liao C, Soung N, Lee S, Yoon D, Lim Y, Lee D, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS.
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat. Struct. Mol. Biol. 16: 876-82, 2009.
6)  Lee KH, Johmura Y, Yu L, Park J, Gao Y, Bang JK, Zhou M, Veenstra TD, Yeon Kim B, Lee KS.
Identification of a novel Wnt5a-CK1epsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
EMBO J. 31: 3104-17, 2012.
7)  Liu F, Park J, Qian W, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR.
Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification.
ACS Chem. Biol. 7: 805-10, 2012.
8)  Liu F, Park J, Qian W, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR.
Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1.
Chembiochem. 13: 1291-6, 2012.
9)  Park JE, Erikson RL, Lee KS.
A self-propelled biological process: Plk1-dependent, product-activated feedforward mechanism.
Cell Cycle. 10: 3411-2, 2011.
10)  Kang YH, Park CH, Kim TS, Soung NK, Bang JK, Kim BY, Park JE, Lee KS.
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
J. Biol. Chem. 286: 19744-57, 2011.
11)  Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, Lee KS.
Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1.
Proc. Natl. Acad. Sci. U.S.A. 108: 11446-51, 2011.
12)  Liao C, Park J, Bang JK, Nicklaus MC, Lee KS.
Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.
ACS Med Chem Lett. 1: 110-114, 2010.
13)  Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, Lee KS.
Polo-box domain: a versatile mediator of polo-like kinase function.
Cell. Mol. Life Sci. 67: 1957-70, 2010.
14)  Soung NK, Park JE, Yu LR, Lee KH, Lee JM, Bang JK, Veenstra TD, Rhee K, Lee KS.
Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells.
Dev. Cell. 16: 539-50, 2009.
15)  Liu F, Park J, Lee K, Burke, Jr. T.
Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides.
Tetrahedron. 65: 9673-79, 2009.
16)  Lee KS, Park JE, Kang YH, Zimmerman W, Soung NK, Seong YS, Kwak SJ, Erikson RL.
Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: self- versus non-self-priming.
Cell Cycle. 7: 141-5, 2008.
17)  Park C*, Park J*, Karpova TS, Soung N, Yu L, Song S, Lee KH, Xia X, Kang E, Dabanoglu I, Oh D, Zhang JY, Kang YH, Wincovitch S, Huffaker TC, Veenstra TD, McNally JG, Lee KS.
Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics.
Eukaryotic Cell. 7: 444-53, 2008.
18)  Lee KS, Oh DY, Kang YH, Park JE.
Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction.
Cell Div. 3: 4, 2008.
19)  Asano S*, Park J*, Yu L, Zhou M, Sakchaisri K, Park CJ, Kang YH, Thorner J, Veenstra TD, Lee KS.
Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
J. Biol. Chem. 281: 27090-8, 2006.
20)  Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
Mol. Cell. 24: 409-22, 2006.
21)  Asano S*, Park J*, Sakchaisri K, Yu L, Song S, Supavilai P, Veenstra TD, Lee KS.
Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast.
EMBO J. 24: 2194-204, 2005.
22)  Lee KS, Asano S, Park JE, Sakchaisri K, Erikson RL.
Monitoring the cell cycle by multi-kinase-dependent regulation of Swe1/Wee1 in budding yeast.
Cell Cycle. 4: 1346-9, 2005.
23)  Lee KS, Park JE, Asano S, Park CJ.
Yeast polo-like kinases: functionally conserved multitask mitotic regulators.
Oncogene. 24: 217-29, 2005.
24)  Sakchaisri K, Asano S, Yu LR, Shulewitz MJ, Park CJ, Park JE, Cho YW, Veenstra TD, Thorner J, Lee KS.
Coupling morphogenesis to mitotic entry.
Proc. Natl. Acad. Sci. U.S.A. 101: 4124-9, 2004.
25)  Park JE, Park CJ, Sakchaisri K, Karpova T, Asano S, McNally J, Sunwoo Y, Leem SH, Lee KS.
Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p.
Mol. Cell. Biol. 24: 9873-86, 2004.
26)  Park CJ, Song S, Giddings TH, Ro HS, Sakchaisri K, Park JE, Seong YS, Winey M, Lee KS.
Requirement for Bbp1p in the proper mitotic functions of Cdc5p in Saccharomyces cerevisiae.
Mol. Biol. Cell. 15: 1711-23, 2004.
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This page was last updated on 7/10/2014.