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Our Science – Citrin Website

Deborah E. Citrin, M.D.

Selected Publications

1)  Prieto DA, Johann DJ, Wei BR, Ye X, Chan KC, Nissley DV, Simpson RM, Citrin DE, Mackall CL, Linehan WM, Blonder J.
Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens.
Biomark Med. 8: 269-86, 2014.
[Journal]
2)  Park JC, Citrin DE, Agarwal PK, Apolo AB.
Multimodal management of muscle-invasive bladder cancer.
Curr Probl Cancer. 38: 80-108, 2014.
[Journal]
3)  Tseng J, Citrin DE, Waldman M, White DE, Rosenberg SA, Yang JC.
Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation.
Cancer. 120: 1426-32, 2014.
[Journal]
4)  Chung EJ, Hudak K, Horton JA, White A, Scroggins BT, Vaswani S, Citrin D.
Transforming Growth Factor Alpha is a Critical Mediator of Radiation Lung Injury.
Radiat. Res. [Epub ahead of print], 2014.
[Journal]
5)  Citrin D, Camphausen KA.
Biomarkers for prostate cancer: who will benefit from local treatment, who harbors occult systemic disease and who needs treatment at all?.
Biomark Med. 7: 823-5, 2013.
[Journal]
6)  Citrin D, Hudak K, Camphausen KA.
Biomarkers to guide therapy or surveillance for prostate cancer.
Biomark Med. 7: 827-9, 2013.
[Journal]
7)  Horton JA, Chung EJ, Hudak KE, Sowers A, Thetford A, White AO, Mitchell JB, Citrin DE.
Inhibition of radiation-induced skin fibrosis with imatinib.
Int. J. Radiat. Biol. 89: 162-70, 2013.
[Journal]
8)  Chung EJ, Urick ME, Kurshan N, Shield W, Asano H, Smith PD, Scroggins BS, Burkeen J, Citrin DE.
MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands.
Int. J. Oncol. 42: 2028-36, 2013.
[Journal]
9)  Horton JA, Hudak KE, Chung EJ, White AO, Scroggins BT, Burkeen JF, Citrin DE.
Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
Stem Cells. 31: 2231-41, 2013.
[Journal]
10)  Gamrekelashvili J, Kapanadze T, Han M, Wissing J, Ma C, Jaensch L, Manns MP, Armstrong T, Jaffee E, White AO, Citrin DE, Korangy F, Greten TF.
Peptidases released by necrotic cells control CD8+ T cell cross-priming.
J. Clin. Invest. 123: 4755-68, 2013.
[Journal]
11)  Horton J, Li F, Chung EJ, Hudak K, White A, Krausz K, Gonzalez F, Citrin D.
Quercetin Inhibits Radiation-Induced Skin Fibrosis.
Radiat. Res. 180: 205-15, 2013.
[Journal]
12)  Citrin DE, Shankavaram U, Horton JA, Shield W, Zhao S, Asano H, White A, Sowers A, Thetford A, Chung EJ.
Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis.
J. Natl. Cancer Inst. 105: 1474-84, 2013.
[Journal]
13)  Prager AJ, Peng CR, Lita E, McNally D, Kaushal A, Sproull M, Compton K, Dahut WL, Figg WD, Citrin D, Camphausen KA.
Urinary aHGF, IGFBP3 and OPN as diagnostic and prognostic biomarkers for prostate cancer.
Biomark Med. 7: 831-41, 2013.
[Journal]
14)  Citrin DE, Hitchcock YJ, Chung EJ, Frandsen J, Urick ME, Shield W, Gaffney D.
Determination of cytokine protein levels in oral secretions in patients undergoing radiotherapy for head and neck malignancies.
Radiat Oncol. 7: 64, 2012.
[Journal]
15)  Baum BJ, Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Goldsmith CM, Burbelo PD, Citrin DE, Mitchell JB, Nottingham LK, Rudy SF, Van Waes C, Whatley MA, Brahim JS, Chiorini JA, Danielides S, Turner RJ, Patronas NJ, Chen CC, Nikolov NP, Illei GG.
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Proc. Natl. Acad. Sci. U.S.A. 109: 19403-7, 2012.
[Journal]
16)  Ko C, Kaushal A, Hammoud DA, Steffen-Smith EA, Bent R, Citrin D, Camphausen K, Warren KE.
Role of Early Postradiation Magnetic Resonance Imaging Scans in Children with Diffuse Intrinsic Pontine Glioma.
Int J Radiat Oncol Biol Phys. 83: 1252-6, 2012.
[Journal]
17)  Saligan LN, Hsiao CP, Wang D, Wang XM, Kaushal A, Citrin D, Barb JJ, Munson PJ, Dionne RA.
Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways.
Brain Behav. Immun. 27: 63-70, 2012.
[Journal]
18)  Gulley JL, Madan RA, Tsang KY, Arlen PM, Camphausen K, Mohebtash M, Kamrava M, Schlom J, Citrin D.
A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver.
Expert Opin Biol Ther. 11: 1409-18, 2011.
[Journal]
19)  Li G, Xie H, Ning H, Citrin D, Kaushal A, Camphausen K, Miller RW.
Correction of motion-induced misalignment in co-registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery.
J Appl Clin Med Phys. 12: 3306, 2011.
[Journal]
20)  Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME.
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy.
Clin Cancer Res. 17: 4550-7, 2011.
[Journal]
21)  Urick ME, Chung EJ, Shield WP, Gerber N, White A, Sowers A, Thetford A, Camphausen K, Mitchell J, Citrin DE.
Enhancement of 5-Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition.
Clin Cancer Res. 17: 5038-47, 2011.
[Journal]
22)  Kelly RJ, Lopez-Chavez A, Citrin D, Janik JE, Morris JC.
Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin.
Mol. Cancer. 10: 35, 2011.
[Journal]
23)  Martires KJ, Baird K, Citrin DE, Hakim FT, Pavletic SZ, Cowen EW.
Localization of sclerotic-type chronic graft-vs-host disease to sites of skin injury: potential insight into the mechanism of isomorphic and isotopic responses.
Arch Dermatol. 147: 1081-6, 2011.
[Journal]
24)  Lonser RR, Song DK, Klapper J, Hagan M, Auh S, Kerr PB, Citrin DE, Heiss JD, Camphausen K, Rosenberg SA.
Surgical management of melanoma brain metastases in patients treated with immunotherapy.
J Neurosurg. 115: 30-6, 2011.
[Journal]
25)  Citrin D, Camphausen K, Wood BJ, Quezado M, Denobile J, Pingpank JF, Royal RE, Alexander HR, Seidel G, Steinberg SM, Shuttack Y, Libutti SK.
A Pilot Feasibility Study of TNFeradeâ„¢ Biologic with Capecitabine and Radiation Therapy Followed by Surgical Resection for the Treatment of Rectal Cancer.
Oncology. 79: 382-8, 2010.
[Journal]
26)  Dudley ME, Gross CA, Langhan MM, Garcia MR, Sherry RM, Yang JC, Phan GQ, Kammula US, Hughes MS, Citrin DE, Restifo NP, Wunderlich JR, Prieto PA, Hong JJ, Langan RC, Zlott DA, Morton KE, White DE, Laurencot CM, Rosenberg SA.
CD8+ enriched.
Clin. Cancer Res. 16: 6122-31, 2010.
[Journal]
27)  Stall B, Zach L, Ning H, Ondos J, Arora B, Shankavaram U, Miller RW, Citrin D, Camphausen K.
Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas.
Radiat Oncol. 5: 5, 2010.
[Journal]
28)  Brown AP, Chung EJ, Urick ME, Shield WE, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.
Evaluation of the fullerene compound DF-1 as a radiation protector.
Radiat Oncol. 5: 34, 2010.
[Journal]
29)  Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA.
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.
Clin. Cancer Res. 16: 2076-84, 2010.
[Journal]
30)  Housri N, Ning H, Ondos J, Choyke P, Camphausen K, Citrin D, Arora B, Shankavaram U, Kaushal A.
Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men with Localized Prostate Cancer.
International journal of radiation oncology, biology, physics. 2010.
[Journal]
31)  Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB.
Radioprotectors and mitigators of radiation-induced normal tissue injury.
Oncologist. 15: 360-71, 2010.
[Journal]
32)  Zach L, Stall B, Ning H, Ondos J, Arora B, Uma S, Miller RW, Citrin D, Camphausen K.
A dosimetric comparison of four treatment planning methods for high grade glioma.
Radiat Oncol. 4: 45, 2009.
[Journal]
33)  Li G, Xie H, Ning H, Lu W, Low D, Citrin D, Kaushal A, Zach L, Camphausen K, Miller RW.
A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change.
Phys Med Biol. 54: 4113-4130, 2009.
[Journal]
34)  Chung EJ, Brown AP, Asano H, Mandler M, Burgan WE, Carter D, Camphausen K, Citrin D.
In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase.
Clin. Cancer Res. 15: 3050-7, 2009.
[Journal]
35)  Van Waes C, Allen CT, Citrin D, Gius D, Colevas AD, Harold NA, Rudy S, Nottingham L, Muir C, Chen Z, Singh AK, Dancey J, Morris JC.
Molecular and Clinical Responses in a Pilot Study of Gefitinib with Paclitaxel and Radiation in Locally Advanced Head-and-Neck Cancer.
Int. J. Radiat. Oncol. Biol. Phys. 2009.
[Journal]
36)  Li G, Arora NC, Xie H, Ning H, Lu W, Low D, Citrin D, Kaushal A, Zach L, Camphausen K, Miller RW.
Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate.
Phys Med Biol. 54: 1963-78, 2009.
[Journal]
37)  Kurshan N, Citrin DE, Camphausen KA.
Research highlights.
Biomark Med. 3: 17-9, 2009.
[Journal]
38)  Fox E, Citrin D, Balis FM.
The Legacy of Cancer Therapy in Children.
J. Natl. Cancer Inst. 2009.
[Journal]
39)  Russo AL, Jedlicka K, Wernick M, McNally D, Kirk M, Sproull M, Smith S, Shankavaram U, Kaushal A, Figg WD, Dahut W, Citrin D, Bottaro DP, Albert PS, Tofilon PJ, Camphausen K.
Urine analysis and protein networking identify met as a marker of metastatic prostate cancer.
Clin. Cancer Res. 15: 4292-8, 2009.
[Journal]
40)  Li G, Xie H, Ning H, Citrin D, Capala J, Maass-Moreno R, Guion P, Arora B, Coleman N, Camphausen K, Miller RW.
Accuracy of 3D volumetric image registration based on CT, MR and PET/CT phantom experiments.
J Appl Clin Med Phys. 9: 2781, 2008.
[Journal]
41)  Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.
Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens.
J. Clin. Oncol. 2008.
[Journal]
42)  Citrin D, Camphausen K.
Advancement of antiangiogenic and vascular disrupting agents combined with radiation.
Cancer Treat. Res. 139: 153-71, 2008.
[Journal]
43)  Li G, Citrin D, Camphausen K, Mueller B, Burman C, Mychalczak B, Miller RW, Song Y.
Advances in 4D Medical Imaging and 4D Radiation Therapy.
Technol. Cancer Res. Treat. 7: 67-82, 2008.
[Journal]
44)  Russo AL, Citrin D, Camphausen K.
Biomarkers in radiation oncology.
Biomark Med. 2: 155-63, 2008.
[Journal]
45)  Brown AP, Citrin DE, Camphausen KA.
Clinical biomarkers of angiogenesis inhibition.
Cancer Metastasis Rev. 27: 415-34, 2008.
[Journal]
46)  Citrin D, Mansueti J, Likhacheva A, Sciuto L, Albert PS, Rudy SF, Cooley-Zgela T, Cotrim A, Solomon B, Colevas AD, Russo A, Morris JC, Herscher L, Smith S, Van Waes C.
Long-Term Outcomes and Toxicity of Concurrent Paclitaxel and Radiotherapy for Locally Advanced Head-and-Neck Cancer.
Int. J. Radiat. Oncol. Biol. Phys. 2008.
[Journal]
47)  Kirk MJ, Hayward RM, Sproull M, Scott T, Smith S, Cooley-Zgela T, Crouse NS, Citrin DE, Camphausen K.
Non-patient related variables affecting levels of vascular endothelial growth factor in urine biospecimens.
J. Cell. Mol. Med. 12: 1250-5, 2008.
[Journal]
48)  Brown AP, Wendler DS, Camphausen KA, Miller FG, Citrin D.
Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations.
J. Clin. Oncol. 26: 3987-94, 2008.
[Journal]
49)  Hayward RM, Kirk MJ, Sproull M, Scott T, Smith S, Cooley-Zgela T, Crouse NS, Citrin DE, Camphausen K.
Post-collection,pre-measurement variables affecting VEGF levels in urine biospecimens.
J. Cell. Mol. Med. 12: 343-50, 2008.
[Journal]
50)  Ko C, Citrin D.
Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neck.
Oral Dis. 15: 121-32, 2008.
[Journal]
51)  Kaushal A, Citrin D.
The role of radiation therapy in the management of sarcomas.
Surg. Clin. North Am. 88: 629-46, viii, 2008.
[Journal]
52)  Panandiker AP, Ning H, Likhacheva A, Ullman K, Arora B, Ondos J, Karimpour S, Packer R, Miller R, Citrin D.
Craniospinal irradiation with spinal IMRT to improve target homogeneity.
Int J Radiat Oncol Biol Phys. 68: 1402-9, 2007.
[Journal]
53)  Kirk MJ, Hayward RM, Sproull M, Scott T, Smith S, Cooley-Zgela T, Crouse NS, Citrin DE, Camphausen K.
Non-patient related variables affecting levels of vascular endothelial growth factor in urine biospecimens.
J Cell Mol Med. Epub ahead of print, 2007.
[Journal]
54)  Brown MW, Ning H, Arora B, Albert PS, Poggi M, Camphausen K, Citrin D.
A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma.
Int. J. Radiat. Oncol. Biol. Phys. 65: 274-83, 2006.
[Journal]
55)  Ahlers CM, Camphausen K, Citrin D, Arlen PM, Gulley JL.
A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors.
Clin Colorectal Cancer. 6: 72-5, 2006.
[Journal]
56)  Citrin D, Menard C, Camphausen K.
Combining radiotherapy and angiogenesis inhibitors: clinical trial design.
Int. J. Radiat. Oncol. Biol. Phys. 64: 15-25, 2006.
[Journal]
57)  Singh AK, Guion P, Susil RC, Citrin DE, Ning H, Miller RW, Ullman K, Smith S, Crouse NS, Godette DJ, Stall BR, Coleman CN, Camphausen K, Menard C.
Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided High Dose Rate brachytherapy boost.
Radiat Oncol. 1: 28, 2006.
[Journal]
58)  Muranski P, Boni A, Wrzesinski C, Citrin DE, Rosenberg SA, Childs R, Restifo NP.
Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?.
Nat Clin Pract Oncol. 3: 668-81, 2006.
[Journal]
59)  Camphausen K, Citrin D, Krishna MC, Mitchell JB.
Implications for tumor control during protection of normal tissues with antioxidants.
J. Clin. Oncol. 23: 5455-7, 2005.
[Journal]
60)  Citrin D, Ning H, Guion P, Li G, Susil RC, Miller RW, Lessard E, Pouliot J, Huchen X, Capala J, Coleman CN, Camphausen K, Ménard C.
Inverse treatment planning based on MRI for HDR prostate brachytherapy.
Int. J. Radiat. Oncol. Biol. Phys. 61: 1267-75, 2005.
[Journal]
61)  Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clin. Cancer Res. 10: 7712-20, 2004.
[Journal]
62)  Citrin D, Lee AK, Scott T, Sproull M, Ménard C, Tofilon PJ, Camphausen K.
In vivo tumor imaging in mice with near-infrared labeled endostatin.
Mol. Cancer Ther. 3: 481-8, 2004.
[Journal]
63)  Citrin D, Scott T, Sproull M, Menard C, Tofilon PJ, Camphausen K.
In vivo tumor imaging using a near-infrared-labeled endostatin molecule.
Int. J. Radiat. Oncol. Biol. Phys. 58: 536-41, 2004.
[Journal]
64)  Citrin D, Camphausen K.
Optical imaging of mice in oncologic research.
Expert Rev Anticancer Ther. 4: 857-64, 2004.
[Journal]
65)  Miranda KM, Nims RW, Thomas DD, Espey MG, Citrin D, Bartberger MD, Paolocci N, Fukuto JM, Feelisch M, Wink DA.
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
J. Inorg. Biochem. 93: 52-60, 2003.
[Journal]
66)  Thomas DD, Miranda KM, Colton CA, Citrin D, Espey MG, Wink DA.
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.
Antioxid. Redox Signal. 5: 307-17, 2003.
[Journal]
67)  Espey MG, Miranda KM, Thomas DD, Xavier S, Citrin D, Vitek MP, Wink DA.
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.
Ann. N. Y. Acad. Sci. 962: 195-206, 2002.
[Journal]
68)  Thomas DD, Miranda KM, Espey MG, Citrin D, Jourd'heuil D, Paolocci N, Hewett SJ, Colton CA, Grisham MB, Feelisch M, Wink DA.
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems.
Meth. Enzymol. 359: 84-105, 2002.
[Journal]
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This page was last updated on 8/21/2014.