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Our Science – Zhao Website

Xue Zhi Zhao, Ph.D.

Selected Publications
1)  Zhao XZ, Burke Jr TR.
Application of protein covalent modification to studying the structure and function of HIV-1 integrase and its inhibitors. In: HIV-1 Integrase: Mechanism and Inhibitor Design. Volume 27.
Hoboken, NJ: John Wiley & Sons, Inc.; 2011. p. 415-427 [Book Chapter]
2)  Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Bioorg. Med. Chem. Lett. 21: 2986-90, 2011. [Journal]
3)  Métifiot M, Johnson B, Smith S, Zhao XZ, Marchand C, Burke T, Hughes S, Pommier Y.
MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
Antimicrobial agents and chemotherapy. 2011. [Journal]
4)  Im YJ, Kuo L, Ren X, Burgos PV, Zhao XZ, Liu F, Burke TR, Bonifacino JS, Freed EO, Hurley JH.
Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.
Structure. 18: 1536-47, 2010. [Journal]
5)  Andrake MD, Ramcharan J, Merkel G, Zhao XZ, Burke TR, Skalka AM.
Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution.
AIDS Res Ther. 6: 14, 2009. [Journal]
6)  Zhao XZ, Maddali K, Marchand C, Pommier Y, Burke TR.
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorg. Med. Chem. 17: 5318-24, 2009. [Journal]
7)  Zhao XZ, Maddali K, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorg. Med. Chem. Lett. 19: 2714-7, 2009. [Journal]
8)  Zhao XZ, Semenova EA, Vu BC, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR.
2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.
J. Med. Chem. 51: 251-9, 2008. [Journal]
9)  Zhao XZ, Semenova EA, Liao C, Nicklaus M, Pommier Y, Burke TR.
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands.
Bioorg. Med. Chem. 14: 7816-25, 2006. [Journal]
10)  Zhao XZ, Peng L, Tang M, Tu YQ, Gao SH.
Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Precise and Stereocontrolled Synthesis of the Key Mother Spiroketal.
Tetrahedron Lett. 46: 6941-6944, 2005. [Journal]
11)  Zhao XZ, Tu YQ, Peng L, Li XQ, Jia YX.
Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthesis of an ester side chain.
Tetrahedron Lett. 45: 3713-3716, 2004. [Journal]
12)  Zhao XZ, Jia YX, Tu YQ.
An efficient synthetic approach to the aromatic sesquiterpenoids via a SmI2-promoted construction of quaternary centre.
J. Chem. Research (S). 54-55, 2003. [Journal]
13)  Li X, Wu B, Zhao XZ, Jia YX, Tu YQ, Li DR.
An Interesting AlEt3-Promoted Stereoselective Tandem Rearrangement/Reduction of α-Hydroxy (or Amino) Heterocyclopropane.
Synlett. 5: 623-626, 2003. [Journal]
14)  Jia YX, Li X, Wu B, Zhao XZ, Tu YQ.
A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals.
Tetrahedron. 58: 1697-1708, 2002. [Journal]
15)  Jia YX, Li X, Wang P, Wu B, Zhao XZ, Tu YQ.
Convergent synthesis of the spiroketal core of the HIV-1 protease inhibitors the didemnaketals. ,.
J. Chem. Soc., Perkin Trans. 1. 565-570, 2002. [Journal]
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This page was last updated on 10/13/2011.