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Our Science – Zhao Website

Xue Zhi Zhao, Ph.D.

Selected Publications

1)  Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR, Hughes SH, Cherepanov P, Pommier Y.
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
ACS Chem. Biol. 8: 209-17, 2013.
[Journal]
2)  Zhao XZ, Metifiot M, Maddali K, Smith SJ, Marchand C, Hughes SH, Pommier Y, Burke TR.
HIV Viral Protein R (Vpr)-Derived Peptides Designed as HIV-1 Integrase Photoaffinity Ligands (Proceedings of the 23rd American Peptide Symposium).
Volume 2013. p. 84-85. [Meeting Proceeding]
3)  Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Bioorg. Med. Chem. Lett. 22: 7309-13, 2012.
[Journal]
4)  Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Chem Biol Drug Des. 79: 157-65, 2012.
[Journal]
5)  Zhao XZ, Burke Jr TR.
Application of protein covalent modification to studying the structure and function of HIV-1 integrase and its inhibitors. In: HIV-1 Integrase: Mechanism and Inhibitor Design. Volume 27.
Hoboken, NJ: John Wiley & Sons, Inc.; 2011. p. 415-427 [Book Chapter]
6)  Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Bioorg. Med. Chem. Lett. 21: 2986-90, 2011.
[Journal]
7)  Métifiot M, Johnson B, Smith S, Zhao XZ, Marchand C, Burke T, Hughes S, Pommier Y.
MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
Antimicrobial agents and chemotherapy. 2011.
[Journal]
8)  Im YJ, Kuo L, Ren X, Burgos PV, Zhao XZ, Liu F, Burke TR, Bonifacino JS, Freed EO, Hurley JH.
Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.
Structure. 18: 1536-47, 2010.
[Journal]
9)  Andrake MD, Ramcharan J, Merkel G, Zhao XZ, Burke TR, Skalka AM.
Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution.
AIDS Res Ther. 6: 14, 2009.
[Journal]
10)  Zhao XZ, Maddali K, Marchand C, Pommier Y, Burke TR.
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
Bioorg. Med. Chem. 17: 5318-24, 2009.
[Journal]
11)  Zhao XZ, Maddali K, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR.
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
Bioorg. Med. Chem. Lett. 19: 2714-7, 2009.
[Journal]
12)  Zhao XZ, Semenova EA, Vu BC, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR.
2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.
J. Med. Chem. 51: 251-9, 2008.
[Journal]
13)  Zhao XZ, Semenova EA, Liao C, Nicklaus M, Pommier Y, Burke TR.
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands.
Bioorg. Med. Chem. 14: 7816-25, 2006.
[Journal]
14)  Zhao XZ, Peng L, Tang M, Tu YQ, Gao SH.
Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Precise and Stereocontrolled Synthesis of the Key Mother Spiroketal.
Tetrahedron Lett. 46: 6941-6944, 2005.
[Journal]
15)  Zhao XZ, Tu YQ, Peng L, Li XQ, Jia YX.
Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthesis of an ester side chain.
Tetrahedron Lett. 45: 3713-3716, 2004.
[Journal]
16)  Zhao XZ, Jia YX, Tu YQ.
An efficient synthetic approach to the aromatic sesquiterpenoids via a SmI2-promoted construction of quaternary centre.
J. Chem. Research (S). 54-55, 2003.
[Journal]
17)  Li X, Wu B, Zhao XZ, Jia YX, Tu YQ, Li DR.
An Interesting AlEt3-Promoted Stereoselective Tandem Rearrangement/Reduction of α-Hydroxy (or Amino) Heterocyclopropane.
Synlett. 5: 623-626, 2003.
[Journal]
18)  Jia YX, Li X, Wu B, Zhao XZ, Tu YQ.
A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals.
Tetrahedron. 58: 1697-1708, 2002.
[Journal]
19)  Jia YX, Li X, Wang P, Wu B, Zhao XZ, Tu YQ.
Convergent synthesis of the spiroketal core of the HIV-1 protease inhibitors the didemnaketals. ,.
J. Chem. Soc., Perkin Trans. 1. 565-570, 2002.
[Journal]
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This page was last updated on 11/25/2013.