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Our Science – Bartesaghi Website

Alberto Bartesaghi, Ph.D.

Selected Publications

1)  Kuybeda O, Frank GA, Bartesaghi A, Borgnia M, Subramaniam S, Sapiro G.
A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography.
J. Struct. Biol. 181: 116-27, 2013.
2)  Milne JL, Borgnia MJ, Bartesaghi A, Tran EE, Earl LA, Schauder DM, Lengyel J, Pierson J, Patwardhan A, Subramaniam S.
Cryo-electron microscopy--a primer for the non-microscopist.
FEBS J. 280: 28-45, 2013.
3)  Schauder DM, Kuybeda O, Zhang J, Klymko K, Bartesaghi A, Borgnia MJ, Mayer ML, Subramaniam S.
Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.
Proc. Natl. Acad. Sci. U.S.A. 110: 5921-6, 2013.
4)  Harris AK, Bartesaghi A, Milne JL, Subramaniam S.
HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1.
J. Virol. 87: 7191-6, 2013.
5)  Bartesaghi A, Merk A, Borgnia MJ, Milne JL, Subramaniam S.
Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.
Nat. Struct. Mol. Biol. 20: 1352-7, 2013.
6)  Frank GA, Bartesaghi A, Kuybeda O, Borgnia MJ, White TA, Sapiro G, Subramaniam S.
Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging.
J. Struct. Biol. 178: 165-76, 2012.
7)  Bartesaghi A, Lecumberry F, Sapiro G, Subramaniam S.
Protein secondary structure determination by constrained single-particle cryo-electron tomography.
Structure. 20: 2003-13, 2012.
8)  Tran EE, Borgnia MJ, Kuybeda O, Schauder DM, Bartesaghi A, Frank GA, Sapiro G, Milne JL, Subramaniam S.
Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.
PLoS Pathog. 8: e1002797, 2012.
9)  Meyerson JR, White TA, Bliss D, Moran A, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Schauder D, Hartnell LM, Nandwani R, Dawood M, Kim B, Kim JH, Sununu J, Yang L, Bhatia S, Subramaniam C, Hurt DE, Gaudreault L, Subramaniam S.
Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.
J Vis Exp. 2011.
10)  White TA, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Nandwani R, Hoxie JA, Bess JW, Lifson JD, Milne JL, Subramaniam S.
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
J. Virol. 85: 12114-23, 2011.
11)  Harris A, Borgnia MJ, Shi D, Bartesaghi A, He H, Pejchal R, Kang YK, Depetris R, Marozsan AJ, Sanders RW, Klasse PJ, Milne JL, Wilson IA, Olson WC, Moore JP, Subramaniam S.
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
Proc. Natl. Acad. Sci. U.S.A. 108: 11440-5, 2011.
12)  White TA, Bartesaghi A, Borgnia MJ, Meyerson JR, de la Cruz MJ, Bess JW, Nandwani R, Hoxie JA, Lifson JD, Milne JL, Subramaniam S.
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
PLoS Pathog. 6: e1001249, 2010.
13)  Bartesaghi A, Subramaniam S.
Membrane protein structure determination using cryo-electron tomography and 3D image averaging.
Curr. Opin. Struct. Biol. 19: 402-7, 2009.
14)  Liu J, Bartesaghi A, Borgnia MJ, Sapiro G, Subramaniam S.
Molecular architecture of native HIV-1 gp120 trimers.
Nature. 455: 109-13, 2008.
15)  Sougrat R, Bartesaghi A, Lifson JD, Bennett AE, Bess JW, Zabransky DJ, Subramaniam S.
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.
PLoS Pathog. 3: e63, 2007.
16)  Subramaniam S, Bartesaghi A, Liu J, Bennett AE, Sougrat R.
Electron tomography of viruses.
Curr. Opin. Struct. Biol. 17: 596-602, 2007.
17)  Bartesaghi A, Sapiro G, Subramaniam S.
An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms.
IEEE Trans Image Process. 14: 1314-23, 2005.
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This page was last updated on 6/17/2014.