Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Yoo Website

Min-Hyuk Yoo, Ph.D.

Selected Publications

1)  Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL.
Abrogated thioredoxin system causes increased sensitivity to TNF-a-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.
PLoS ONE. 8: e71427, 2013.
2)  Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL.
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
Chem. Res. Toxicol. 26: 1088-96, 2013.
3)  Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL.
Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin reductase status.
Mol. Cells. 36: 151-7, 2013.
4)  Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko DE, Gladyshev VN, Hatfield DL, Davis CD.
Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.
PLoS ONE. 7: e50574, 2012.
5)  Tobe R, Yoo MH, Fradejas N, Carlson BA, Calvo S, Gladyshev VN, Hatfield DL.
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
Biochem. J. 445: 423-30, 2012.
6)  Carlson BA, Yoo MH, Tobe R, Mueller C, Naranjo-Suarez S, Hoffmann VJ, Gladyshev VN, Hatfield DL.
Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.
Carcinogenesis. 33: 1806-13, 2012.
7)  Turanov AA, Xu XM, Carlson BA, Yoo MH, Gladyshev VN, Hatfield DL.
Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis.
Adv Nutr. 2: 122-8, 2011.
8)  Carlson BA, Yoo MH, Conrad M, Gladyshev VN, Hatfield DL, Park JM.
Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.
Mol. Immunol. 49: 311-6, 2011.
9)  Yoo MH, Carlson BA, Tsuji P, Irons R, Gladyshev VN, Hatfield DL.
Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.
Meth. Enzymol. 474: 255-75, 2010.
10)  Cho KJ, Seo JM, Shin Y, Yoo MH, Park CS, Lee SH, Chang YS, Cho SH, Kim JH.
Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor.
Am. J. Respir. Cell Mol. Biol. 42: 294-303, 2010.
11)  Irons R, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, Davis CD.
Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.
Cancer Prev Res (Phila). 3: 630-9, 2010.
12)  Yoo MH, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL.
Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.
Antioxid. Redox Signal. 12: 819-27, 2010.
13)  Turanov AA, Kehr S, Marino SM, Yoo MH, Carlson BA, Hatfield DL, Gladyshev VN.
Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.
Biochem. J. 430: 285-93, 2010.
14)  Carlson BA, Yoo MH, Shrimali RK, Irons R, Gladyshev VN, Hatfield DL, Park JM.
Role of selenium-containing proteins in T-cell and macrophage function.
Proc Nutr Soc. 69: 300-10, 2010.
15)  Xu XM, Turanov AA, Carlson BA, Yoo MH, Everley RA, Nandakumar R, Sorokina I, Gygi SP, Gladyshev VN, Hatfield DL.
Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery.
Proc. Natl. Acad. Sci. U.S.A. 2010.
16)  Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL.
Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development.
Molecules. 14: 3509-27, 2009.
17)  Carlson BA, Yoo MH, Sano Y, Sengupta A, Kim JY, Irons R, Gladyshev VN, Hatfield DL, Park JM.
Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.
BMC Immunol. 10: 57, 2009.
18)  Hatfield DL, Yoo MH, Carlson BA, Gladyshev VN.
Selenoproteins that function in cancer prevention and promotion.
Biochim. Biophys. Acta. 1790: 1541-5, 2009.
19)  Labunskyy VM, Yoo MH, Hatfield DL, Gladyshev VN.
Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses.
Biochemistry. 48: 8458-65, 2009.
20)  Xu XM, Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL.
Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression.
Nat Protoc. 4: 1338-48, 2009.
21)  Yoo MH, Hatfield DL.
The cancer stem cell theory: is it correct?.
Mol. Cells. 26: 514-6, 2008.
22)  Yoo MH, Xu XM, Turanov AA, Carlson BA, Gladyshev VN, Hatfield DL.
A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.
RNA. 13: 921-9, 2007.
23)  Yoo MH, Xu XM, Carlson BA, Patterson AD, Gladyshev VN, Hatfield DL.
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
PLoS ONE. 2: e1112, 2007.
24)  Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL.
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
J. Biol. Chem. 281: 13005-8, 2006.
25)  Yoo MH, Song H, Woo CH, Kim H, Kim JH.
Role of the BLT2, a leukotriene B4 receptor, in Ras transformation.
Oncogene. 23: 9259-68, 2004.
26)  Woo CH, Yoo MH, You HJ, Cho SH, Mun YC, Seong CM, Kim JH.
Transepithelial migration of neutrophils in response to leukotriene B4 is mediated by a reactive oxygen species-extracellular signal-regulated kinase-linked cascade.
J. Immunol. 170: 6273-9, 2003.
27)  Lee M, You HJ, Cho SH, Woo CH, Yoo MH, Joe EH, Kim JH.
Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.
Biochem. J. 366: 937-43, 2002.
28)  Jeong DW, Yoo MH, Kim TS, Kim JH, Kim IY.
Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa B activation.
J. Biol. Chem. 277: 17871-6, 2002.
29)  Eom YW, Yoo MH, Woo CH, Hwang KC, Song WK, Yoo YJ, Chun JS, Kim JH.
Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts.
Biochem. Biophys. Res. Commun. 285: 825-9, 2001.
30)  Yoo MH, Woo CH, You HJ, Cho SH, Kim BC, Choi JE, Chun JS, Jhun BH, Kim TS, Kim JH.
Role of the cytosolic phospholipase A2-linked cascade in signaling by an oncogenic, constitutively active Ha-Ras isoform.
J. Biol. Chem. 276: 24645-53, 2001.
31)  Woo CH, Kim BC, Kim KW, Yoo MH, Eom YW, Choi EJ, Na DS, Kim JH.
Role of cytosolic phospholipase A(2) as a downstream mediator of Rac in the signaling pathway to JNK stimulation.
Biochem. Biophys. Res. Commun. 268: 231-6, 2000.
32)  Woo CH, Eom YW, Yoo MH, You HJ, Han HJ, Song WK, Yoo YJ, Chun JS, Kim JH.
Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade.
J. Biol. Chem. 275: 32357-62, 2000.
Click Here to View Collapsed Bibliography.

This page was last updated on 4/16/2014.