Our Science – Marchand Website
Christophe Marchand, Ph.D.
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| 2007 NCI Director's Innovation Award Ceremony |
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| Christophe Marchand and John E. Niederhuber, Director of the National Cancer Institute on January 09, 2007. |
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| Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure |
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| Topoisomerase I-DNA complex trapped by the norindenoisoquinoline AI-III-52 (Spheres colored by elements). Topoisomerase I is represented in ribbon to allow visualization of the catalytic tyrosine (Sticks colored in magenta) and to show the drug intercalation between its two flanking base pairs (PDB ID code 1TL8). |
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| Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure |
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| Topoisomerase I-DNA complex trapped by the norindenoisoquinoline AI-
III-52 (Spheres colored by elements). Topoisomerase I is shown in a surface view to represent the depth of the norindenoisoquinoline binding pocket (PDB ID code 1TL8). |
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| Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure |
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| Stacking of a drug molecule between two base pairs flanking the topoisomerase I cleavage site is a common mechanism for the norindenoisoquinolines (Spheres colored by elements). The catalytic tyrosine is shown in sticks and magenta at the top of the picture (PDB ID code 1TL8). |
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| Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure |
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| View of norindenoisoquinoline-Topoisomerase I-DNA complex through the DNA Double helix. The norindenoisoquinoline drug molecule (Spheres colored by elements) is stacked between two base pairs flanking the topoisomerase I (ribbon representation) cleavage site. The catalytic tyrosine is shown in Sticks and magenta at the top of the picture (PDB ID code 1TL8). |
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| 320 samples on a single gel |
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| Christophe Marchand & Thomas Dexheimer on March 9, 2009 |
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| Flying Reagent Dispensers... |
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| Thomas Dexheimer & Christophe Marchand |
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| Breaking the 500-sample barrier |
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| Thomas Dexheimer & Christophe Marchand on April, 01, 2009 |
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This page was last updated on 9/28/2009.
