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Christophe Marchand, Ph.D.

Gallery Pictures

2007 NCI Director's Innovation Award Ceremony
2007 NCI Director's Innovation Award Ceremony
Christophe Marchand and John E. Niederhuber, Director of the National Cancer Institute on January 09, 2007.
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Topoisomerase I-DNA complex trapped by the norindenoisoquinoline AI-III-52 (Spheres colored by elements). Topoisomerase I is represented in ribbon to allow visualization of the catalytic tyrosine (Sticks colored in magenta) and to show the drug intercalation between its two flanking base pairs (PDB ID code 1TL8).
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Topoisomerase I-DNA complex trapped by the norindenoisoquinoline AI-
III-52 (Spheres colored by elements). Topoisomerase I is shown in a surface view to represent the depth of the norindenoisoquinoline binding pocket (PDB ID code 1TL8).
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Stacking of a drug molecule between two base pairs flanking the topoisomerase I cleavage site is a common mechanism for the norindenoisoquinolines (Spheres colored by elements). The catalytic tyrosine is shown in sticks and magenta at the top of the picture (PDB ID code 1TL8).
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
Norindenoisoquinoline-Topoisomerase I-DNA co-crystal structure
View of norindenoisoquinoline-Topoisomerase I-DNA complex through the DNA Double helix. The norindenoisoquinoline drug molecule (Spheres colored by elements) is stacked between two base pairs flanking the topoisomerase I (ribbon representation) cleavage site. The catalytic tyrosine is shown in Sticks and magenta at the top of the picture (PDB ID code 1TL8).
320 samples on a single gel
320 samples on a single gel
Christophe Marchand & Thomas Dexheimer on March 9, 2009
Flying Reagent Dispensers...
Flying Reagent Dispensers...
Thomas Dexheimer & Christophe Marchand
Breaking the 500-sample barrier
Breaking the 500-sample barrier
Thomas Dexheimer & Christophe Marchand on April, 01, 2009
Human Tyrosyl DNA Phosphodiesterase I (TDP1)
Human Tyrosyl DNA Phosphodiesterase I (TDP1)
Surface representation of TDP1 with its DNA-Protein substrate in the catalytic site (PDB ID: 1NOP).
Human Tyrosyl DNA Phosphodiesterase I (TDP1)
Human Tyrosyl DNA Phosphodiesterase I (TDP1)
Molecular contacts between TDP1 residues and its DNA-Protein substrate (PDB ID: 1NOP)

This page was last updated on 9/25/2013.