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Gordon L. Hager, Ph.D.
|Structure of MMTV Chromatin|
|When MMTV retrovirus integrates into host cell DNA as a provirus, the LTR (containing transcriptional regulatory sequences) is organized into a reproducible chromatin structure.|
|This structure is characterized at low resolution by a series of positioned, or "phased" nucleosomes. Steroid receptors bind to the B/C nucleosome region and activate transcription.
When replicated in mammalian cells, this promoter acquires a specific nucleoprotein organization.
|An important component of this activation mechanism is a nucleoprotein remodeling event (in the B nucleosome region) that leads to loss of chromatin repression.|
This page was last updated on 11/24/2010.