Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health
CCR - For Our Staff| Home |

Our Science – Hager Website

Gordon L. Hager, Ph.D.

Gallery Pictures

Structure of MMTV Chromatin
Structure of MMTV Chromatin
When MMTV retrovirus integrates into host cell DNA as a provirus, the LTR (containing transcriptional regulatory sequences) is organized into a reproducible chromatin structure.
This structure is characterized at low resolution by a series of positioned, or "phased" nucleosomes. Steroid receptors bind to the B/C nucleosome region and activate transcription.

When replicated in mammalian cells, this promoter acquires a specific nucleoprotein organization.
An important component of this activation mechanism is a nucleoprotein remodeling event (in the B nucleosome region) that leads to loss of chromatin repression.

This page was last updated on 11/24/2010.