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W. Michael Kuehl, M.D.

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Long-lived vs short-lived plasma cells
Long-lived vs short-lived plasma cells
Pre-malignant non-IgM MGUS and multiple myeloma are tumors of long-lived bone marrow plasma cells.
Sequential disruption of RB pathway in myeloma
Sequential disruption of RB pathway in myeloma
The TC classification is based on dysregulation of a CYCLIN D gene; increased proliferation can involve additional disruption of this pathway.
NFKB pathway in myeloma
NFKB pathway in myeloma
Activation of the NFKB pathway is critical in plasma cells but also in MGUS and MM tumors.
Molecular pathogenesis of MGUS/MM
Molecular pathogenesis of MGUS/MM

This page was last updated on 9/8/2008.