Our Science – Kuehl Website
W. Michael Kuehl, M.D.
|Long-lived vs short-lived plasma cells|
|Pre-malignant non-IgM MGUS and multiple myeloma are tumors of long-lived bone marrow plasma cells.|
|Sequential disruption of RB pathway in myeloma|
|The TC classification is based on dysregulation of a CYCLIN D gene; increased proliferation can involve additional disruption of this pathway.|
|NFKB pathway in myeloma|
|Activation of the NFKB pathway is critical in plasma cells but also in MGUS and MM tumors.|
|Molecular pathogenesis of MGUS/MM|
This page was last updated on 9/8/2008.