Our Science – Kuehl Website
W. Michael Kuehl, M.D.
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| Long-lived vs short-lived plasma cells |
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| Pre-malignant non-IgM MGUS and multiple myeloma are tumors of long-lived bone marrow plasma cells. |
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| Sequential disruption of RB pathway in myeloma |
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| The TC classification is based on dysregulation of a CYCLIN D gene; increased proliferation can involve additional disruption of this pathway. |
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| NFKB pathway in myeloma |
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| Activation of the NFKB pathway is critical in plasma cells but also in MGUS and MM tumors. |
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| Molecular pathogenesis of MGUS/MM |
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This page was last updated on 9/8/2008.
